The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The SaeR/S Gene Regulatory System Is Essential for Innate Immune Evasion by Staphylococcus aureus
Open accessAbstract
Methicillin-resistant Staphylococcus aureus is problematic both in hospitals and in the community. Currently, we have limited understanding of mechanisms of innate immune evasion used by S. aureus. To that end, we created an isogenic deletion mutant in strain MW2 (USA400) of the saeR/S 2-component gene regulatory system and studied its role in mouse models of pathogenesis and during human neutrophil interaction. In this study, we demonstrate that saeR/S plays a distinct role in S. aureus pathogenesis and is vital for virulence of MW2 in a mouse model of sepsis. Moreover, deletion of saeR/S significantly impaired survival of MW2 in human blood and after neutrophil phagocytosis. Microarray analysis revealed that SaeR/S of MW2 influences expression of a wide variety of genes with diverse biological functions. These data provide new insight into how virulence is regulated in S. aureus and associates a specific staphylococcal gene-regulatory system with invasive staphylococcal disease.
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Klevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726 · cited 1×
“Community-associated MRSA primarily causes skin and soft-tissue infections, but the most prominent strains, classified as pulsed-field gel electrophoresis types USA300 and USA400, have also been associated with severe syndromes or pathologies, including septicemia, necrotizing pneumonia, and necrotizing fasciitis [2-6…”
BackgroundThe immunopathogenesis of sepsis
Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742
Gillet, Y., Issartel, B., Vanhems, P., Fournet, J.-C., Lina, G., Bes, M., Vandenesch, F., Piémont, Y., Brousse, N., Floret, D., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07877-7 · Cited by 1,514
Methicillin-Resistant Staphylococcus aureus Disease in Three Communities
Fridkin, S. K., Hageman, J. C., Morrison, M., Sanza, L. T., Como-Sabetti, K., Jernigan, J. A., Harriman, K., Harrison, L. H., Lynfield, R., & Farley, M. M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043252 · Cited by 1,493
Miller, L. G., Perdreau-Remington, F., Rieg, G., Mehdi, S., Perlroth, J., Bayer, A. S., Tang, A. W., Phung, T. O., & Spellberg, B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042683 · Cited by 1,053
Insights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils
Voyich, J. M., Braughton, K. R., Sturdevant, D. E., Whitney, A. R., Saïd-Salim, B., Porcella, S. F., Long, R. D., Dorward, D. W., Gardner, D. J., Kreiswirth, B. N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3907 · Cited by 563
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Cited by
Regulation of Staphylococcus aureus Virulence
Jenul, C., & Horswill, A. R. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0031-2018 · Cited by 549
The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus
Alonzo, F., & Torres, V. J. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00055-13 · Cited by 276
Baker, J., Sitthisak, S., Sengupta, M., Johnson, M., Jayaswal, R. K., & Morrissey, J. A. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.02268-09 · Cited by 163
Grossoehme, N., Kehl-Fie, T. E., Ma, Z., Adams, K. W., Cowart, D. M., Scott, R. A., Skaar, E. P., & Giedroc, D. P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.220012 · Cited by 101
Metadata
- Authors
- Voyich, J. M., Vuong, C., DeWald, M., Nygaard, T. K., Kocianova, S., Griffith, S., Jones, J., Iverson, C., Sturdevant, D. E., Braughton, K. R., Whitney, A. R., Otto, M., & DeLeo, F. R.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-06
- Volume
- 199
- Issue
- 11
- Pages
- 1698-1706
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W1973836606
- Cited by
- 208
- References
- 6
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Voyich, J. M., Vuong, C., DeWald, M., Nygaard, T. K., Kocianova, S., Griffith, S., Jones, J., Iverson, C., Sturdevant, D. E., Braughton, K. R., Whitney, A. R., Otto, M., & DeLeo, F. R. (2009). The SaeR/S Gene Regulatory System Is Essential for Innate Immune Evasion by Staphylococcus aureus. The Journal of Infectious Diseases. https://doi.org/10.1086/598967
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
