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Cited by 74Viral-associated cancers and disordersCytomegalovirus and herpesvirus researchHerpesvirus Infections and Treatments

Infectious Mononucleosis in University Students in the United Kingdom: Evaluation of the Clinical Features and Consequences of the Disease

Macsween, Karen F., Higgins, Craig D., McAulay, Karen A., Williams, Hilary, Harrison, Nadine, Swerdlow, Anthony J., Crawford, Dorothy H.·2010·Clinical Infectious Diseases
DOI 10.1086/650456
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Abstract

Infectious mononucleosis (IM) resulted in marked reductions in student study time, social activities, and physical exercise, and sustained hypersomnia. Females were more likely to discontinue their studies following IM and reported more-prolonged fatigue. Elevated levels of γΔ T cells persisted into the convalescent period. Background. Infectious mononucleosis (IM) is common among university students. We undertook to analyze the clinical features and sequelae of the disease in a cohort of students at Edinburgh University. Methods. Consecutive IM case patients were recruited from 2000 through 2002 at the University Health Service after diagnosis of IM. Results. IM resulted in marked reductions in student study time, physical exercise, and non–exercise-related social activities, and sustained increases in reported number of hours of sleep. The disease profile differed between the sexes, with significantly more females reporting fatigue, which was more likely to be prolonged (P=.003) and to lead to loss of study time (P=.013). Female case patients were more likely to discontinue their studies following IM (16% vs 0%; P=.056). Within the typically elevated lymphocyte counts in IM, we identified an elevated γΔ T cell component that may contribute to the disease pathogenesis. Conclusions. IM results in substantial morbidity among university students, reported as more profound in females, and affecting academic studies, physical exercise, and social activities. Immunization to prevent IM and strategies to reduce post-IM disability would be beneficial in this population.

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Crossref · 10.1086/650456

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  • In patients with Epstein Barr virus-linked infectious mononucleosis, self-reported sleep duration was markedly increased and debilitating daytime sleepiness persisted over many years.

    “In patients with an infectious illness linked to the Epstein Barr virus (EBV), such as infectious mononucleosis, self-reported sleep duration was markedly increased (349) and debilitating daytime sleepiness persisted over many years (218).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [349]

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Authors
Macsween, K. F., Higgins, C. D., McAulay, K. A., Williams, H., Harrison, N., Swerdlow, A. J., & Crawford, D. H.
Affiliations
  • University of Edinburgh (GB)
  • London School of Hygiene & Tropical Medicine (GB)
  • Institute of Cancer Research (GB)
Corresponding author
Macsween, Karen F.
ORCID
Swerdlow, Anthony J.
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2010-03
Volume
50
Issue
5
Pages
699-706
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/650456
OpenAlex
W2171537173
Cited by
74
References
36
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 9 · 2015: 5 · 2014: 11 · 2013: 4 · 2012: 3
FWCI
2.04
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Keywords
infectious mononucleosis, Epstein-Barr virus, university students, research impact, fatigue, hypersomnia, γδ T cells, sex differences, physical activity, social activity, convalescence, morbidity
MeSH terms
Female, United Kingdom, Humans, Infectious Mononucleosis, Learning Disabilities, Male, Sex Factors, Social Behavior, Students, Universities, Exercise, Treatment Outcome, Young Adult

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