The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Markers of Inflammation, Coagulation, and Renal Function Are Elevated in Adults with HIV Infection
Open accessAbstract
BACKGROUND: Human immunodeficiency virus (HIV) replication and immune activation may increase inflammation and coagulation biomarkers. Limited data exist comparing such biomarkers in persons with and without HIV infection. METHODS: For persons 45-76 years of age, levels of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, D-dimer, and cystatin C were compared in 494 HIV-infected individuals in the Strategies for Management of Anti-Retroviral Therapy (SMART) study and 5386 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) study. For persons 33-44 years of age, hsCRP and IL-6 levels were compared in 287 participants in the SMART study and 3231 participants in the Coronary Artery Development in Young Adults (CARDIA) study. RESULTS: hsCRP and IL-6 levels were 55% (P < . 001) and 62 (P < . 001) higher among HIV-infected participants than among CARDIA study participants. Compared with levels noted in MESA study participants, hsCRP, IL-6, D-dimer, and cystatin C levels were 50%, 152%, 94%, and 27% higher, respectively (P < . 001, for each), among HIV-infected participants. HIV-infected participants receiving antiretroviral therapy who had HIV RNA levels 400 copies/mL had levels higher (by 21% to 60%) (P < . 001) than those in the general population, for all biomarkers. CONCLUSIONS: hsCRP, IL-6, D-dimer, and cystatin C levels are elevated in persons with HIV infection and remain so even after HIV RNA levels are suppressed with antiretroviral therapy. Additional research is needed on the pathophysiology of HIV-induced activation of inflammatory and coagulation pathways, to guide potential interventions.
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“However, this therapy does not protect patients from the persistent immune activation, chronic inflammation, and excess risk of developing CVD and frailty131–135.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [132]
In the citing paper
“Many (but not all) biomarkers associated with inflammation (e.g., IL-6, sCD14) and end-organ diseases common in seniors (e.g., cystatin C as a marker of declining renal function) are higher in antiretroviral-treated adults than uninfected adults (50).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [50]
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Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
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Self-citationC-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18921 · Cited by 4,694
Multi-Ethnic Study of Atherosclerosis: Objectives and Design
Bild, D. E. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf113 · Cited by 3,942
CD4+ Count–Guided Interruption of Antiretroviral Treatment
The Strategies for Management of Antiretroviral Therapy (SMART) Study Group (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062360 · Cited by 2,250
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Self-citationAssociations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488
Self-citationCystatin C and the Risk of Death and Cardiovascular Events among Elderly Persons
Shlipak, M. G., Sarnak, M. J., Katz, R., Fried, L. F., Seliger, S. L., Newman, A. B., Siscovick, D. S., & Stehman‐Breen, C. O. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043161 · Cited by 1,241
Self-citationRelation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690
The end of AIDS: HIV infection as a chronic disease
Deeks, S. G., Lewin, S. R., & Havlir, D. V. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61809-7 · Cited by 2,081
HIV Infection, Inflammation, Immunosenescence, and Aging
Deeks, S. G. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-042909-093756 · Cited by 1,349
Systemic Effects of Inflammation on Health during Chronic HIV Infection
Deeks, S. G., Tracy, R. P., & Douek, D. C. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.001 · Cited by 910
Self-citationNational Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2
Jacobson, T. A., Maki, K. C., Orringer, C. E., Jones, P. H., Kris-Etherton, P., Sikand, G., La Forge, R., Daniels, S. R., Wilson, D. P., Morris, P. B., et al. (2015) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2015.09.002 · Cited by 784
Metadata
- Authors
- Neuhaus, J., Jacobs, Jr., Baker, J. V., Calmy, A., Duprez, D., La Rosa, A., Kuller, L. H., Pett, S. L., Ristola, M., Ross, M. J., Shlipak, M. G., Tracy, R., & Neaton, J. D.
- Affiliations
- University of Minnesota (US)
- University of Geneva (CH)
- University of Pittsburgh (US)
- UNSW Sydney (AU)
- University of Helsinki (FI)
- Icahn School of Medicine at Mount Sinai (US)
- University of California, San Francisco (US)
- University of Vermont (US)
- Corresponding author
- Neuhaus, Jacqueline
- ORCID
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-15
- Volume
- 201
- Issue
- 12
- Pages
- 1788-1795
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC2872049
- OpenAlex
- W2127517680
- Cited by
- 869
- References
- 33
- Citations by year
- 2026: 29 · 2025: 25 · 2024: 30 · 2023: 50 · 2022: 59 · 2021: 49 · 2020: 60 · 2019: 54 · 2018: 53 · 2017: 66 · 2016: 58 · 2015: 65 · 2014: 68 · 2013: 67 · 2012: 69
- FWCI
- 61.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Archive ouverte UNIGE (University of Geneva) (acceptedVersion, other-oa)
- reroDoc Digital Library (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (n01hc95095-66-0-1, n01hc95164-17-0-1, n01hc48050-59-0-1, n01hc48048-58-0-1, n01hc95165-34-0-1, n01hc48047-55-0-1, n01hc95161-24-0-1, n01hc095169-003, n01hc95166-21-0-1, n01hc48049-61-0-1, n01hc95162-31-0-1, n01hc95168-27-0-1, n01hc95160-18-0-1, n01hc095167-000, N01-HC- 95159, n01hc95163-22-0-1, n01hc95159-40-0-1, N01‐HC‐95169)
- National Heart, Lung, and Blood Institute (N01HC48050, N01 HC-95159, N01-HC095169, N01-HC-095165, N01 HC 95095, N01 HC095163, N01 HC048048, N01-HC-048049, N01-HC-095159, N01 HC095168, NO1-HC-48049, N01-HC-095162, N01 HC095095, N01-HC-095161, N01 HC048050, N01-HC48048, N01 HC095167, N01-HC-48-049, N01-HC-095160, N01 HC095166, N01 HC095164, N01 HC048047, NO1-HC-95095, N01-HC-480-47, N01 HC95169)
- National Institute of Allergy and Infectious Diseases (U01 AI46362, U01AI046362, U01AI042170)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078510)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- HIV infection, inflammatory markers, coagulation markers, renal function, high-sensitivity C-reactive protein, interleukin-6, D-dimer, cystatin C, antiretroviral therapy, viral suppression, immune activation, cardiovascular risk
- MeSH terms
- Adult, Aged, Blood Coagulation Disorders, C-Reactive Protein, Female, Fibrin Fibrinogen Degradation Products, Humans, Inflammation, Kidney Diseases, Male, Middle Aged, Biomarkers, HIV Infections, Interleukin-6, Anti-HIV Agents, Viral Load, Cystatin C
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