Multi-Ethnic Study of Atherosclerosis: Objectives and Design
Abstract
The Multi-Ethnic Study of Atherosclerosis was initiated in July 2000 to investigate the prevalence, correlates, and progression of subclinical cardiovascular disease (CVD) in a population-based sample of 6,500 men and women aged 45-84 years. The cohort will be selected from six US field centers. Approximately 38% of the cohort will be White, 28% African-American, 23% Hispanic, and 11% Asian (of Chinese descent). Baseline measurements will include measurement of coronary calcium using computed tomography; measurement of ventricular mass and function using cardiac magnetic resonance imaging; measurement of flow-mediated brachial artery endothelial vasodilation, carotid intimal-medial wall thickness, and distensibility of the carotid arteries using ultrasonography; measurement of peripheral vascular disease using ankle and brachial blood pressures; electrocardiography; and assessments of microalbuminuria, standard CVD risk factors, sociodemographic factors, life habits, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for use in nested case-control studies. DNA will be extracted and lymphocytes will be immortalized for genetic studies. Measurement of selected subclinical disease indicators and risk factors will be repeated for the study of progression over 7 years. Participants will be followed through 2008 for identification and characterization of CVD events, including acute myocardial infarction and other coronary heart…
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MESA is a prospective, population-based cohort study of 6814 men and women free of cardiovascular disease at baseline, aged 45 to 84 years, recruited from 6 US clinical centers beginning in 2000.
“MESA is a prospective, population-based cohort study of 6814 men and women free of cardiovascular disease at baseline, aged 45 to 84 years, with recruitment from 6 US clinical centers beginning in 200042.”
From Cross-ancestry comparison of aptamer and antibody protein measures (2026) · cites this paper as [42]
Most studies used centralized adjudication processes or registry linkage rather than self-report alone in ascertaining events, reducing information bias.
“Most studies18–25,27–35 used centralized adjudication processes or registry linkage rather than self-report alone in ascertaining events, reducing information bias.”
From ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies (2016) · cites this paper as [27]
Few studies were available with African American (n = 2) and Chinese (n = 2) subgroups.
“few studies were available with African American (n = 2 studies: CHS and MESA) and Chinese subgroups (n = 2 studies: SCHS and MESA).27,33”
From ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies (2016) · cites this paper as [27]
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- Authors
- Bild, D. E.
- Affiliations
- National Heart, Lung, and Blood Institute (US)
- Corresponding author
- Bild, D. E.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-11-01
- Volume
- 156
- Issue
- 9
- Pages
- 871-881
- ISSN
- 0002-9262 (ISSN-L)
- OpenAlex
- W2156097706
- Cited by
- 3,942
- References
- 21
- Citations by year
- 2026: 198 · 2025: 238 · 2024: 243 · 2023: 233 · 2022: 234 · 2021: 269 · 2020: 190 · 2019: 187 · 2018: 187 · 2017: 196 · 2016: 234 · 2015: 228 · 2014: 227 · 2013: 211 · 2012: 149
- FWCI
- 18.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health (n01hc095169-003, n01hc95159-40-0-1)
- National Heart, Lung, and Blood Institute (N01 HC-95159, N01 HC95169)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- Multi-Ethnic Study of Atherosclerosis, subclinical cardiovascular disease, atherosclerosis, coronary artery calcium, ventricular mass, endothelial function, carotid intima-media thickness, peripheral vascular disease, microalbuminuria, cardiovascular risk factors, ethnic diversity, cohort studies, cardiovascular disease progression, cardiovascular events
- MeSH terms
- Aged, Aged, 80 and over, Coronary Artery Disease, Epidemiologic Methods, Female, Goals, Humans, Male, Middle Aged, Research Design, Risk Factors, United States, Cohort Studies, Prevalence, Disease Progression
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