Cited by 224Infection Control in HealthcareInfection Control and VentilationMedical Device Sterilization and Disinfection

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Room Decontamination with UV Radiation

Rutala, William A., Gergen, Maria F., Weber, David J.·2010·Infection Control & Hospital Epidemiology

DOI 10.1086/656244

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Abstract

OBJECTIVE: To determine the effectiveness of a UV-C-emitting device to eliminate clinically important nosocomial pathogens in a contaminated hospital room. METHODS: This study was carried out in a standard but empty hospital room (phase 1) and in a room previously occupied by a patient with methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) infection (phase 2) in an acute care tertiary hospital in North Carolina from January 21 through September 21, 2009. During phase 1, 8 x 8 cm Formica sheets contaminated with approximately 10(4)-10(5) organisms of MRSA, VRE, multidrug-resistant (MDR) Acinetobacter baumannii, or Clostridium difficile spores were placed in a hospital room, both in direct line of sight of the UV-C device and behind objects. After timed exposure, the presence of the microbes was assessed. During phase 2, specific sites in rooms that had housed patients with MRSA or VRE infection were sampled before and after UV-C irradiation. After timed exposure, the presence of MRSA and VRE and total colony counts were assessed. RESULTS: In our test room, the effectiveness of UV-C radiation in reducing the counts of vegetative bacteria on surfaces was more than 99.9% within 15 minutes, and the reduction in C. difficile spores was 99.8% within 50 minutes. In rooms occupied by patients with MRSA, UV-C irradiation of approximately 15 minutes duration resulted in a decrease in total CFUs per plate (mean, 384 CFUs vs 19 CFUs; P < .001), in the number of samples positive for MRSA (81 [20.3%] of 400 plates vs 2 [0.5%] of 400 plates; P < .001), and in MRSA counts per MRSA-positive plate (mean, 37 CFUs vs 2 CFUs; P < .001). CONCLUSIONS: This UV-C device was effective in eliminating vegetative bacteria on contaminated surfaces both in the line of sight and behind objects within approximately 15 minutes and in eliminating C. difficile spores within 50 minutes.

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Authors: Rutala, W. A., Gergen, M. F., & Weber, D. J.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Rutala, William A.
ORCID: Weber, David J.
Venue: Infection Control & Hospital Epidemiology
Publisher: Cambridge University Press (CUP)
Published: 2010-10
Volume: 31
Issue: 10
Pages: 1025-1029
ISSN: 0899-823X (ISSN-L)
1559-6834
DOI: 10.1086/656244
OpenAlex: W2143825991
Cited by: 221
References: 14
Citations by year: 2026: 9 · 2025: 4 · 2024: 17 · 2023: 21 · 2022: 14 · 2021: 13 · 2020: 15 · 2019: 15 · 2018: 13 · 2017: 14 · 2016: 16 · 2015: 14 · 2014: 17 · 2013: 19 · 2012: 10
FWCI: 8.00
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 1554 d)
Locations: Infection Control and Hospital Epidemiology (publishedVersion)
PubMed (publishedVersion)
Infection Control and Hospital Epidemiology
Funders: U.S. Public Health Service (1ULRR025747-01)
Topics: Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Infection Control and Ventilation
Life Sciences › Immunology and Microbiology › Microbiology › Medical Device Sterilization and Disinfection
Keywords: UV-C disinfection, nosocomial pathogens, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, Acinetobacter baumannii, multidrug-resistant bacteria, surface decontamination, hospital room disinfection
MeSH terms: Bacteria, Bacterial Infections, Cross Infection, Decontamination, Hospitals, Humans, North Carolina, Patients' Rooms, Ultraviolet Rays, Colony Count, Microbial, Clostridioides difficile, Enterococcus, Methicillin-Resistant Staphylococcus aureus

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