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Cited by 224Infection Control in HealthcareInfection Control and VentilationMedical Device Sterilization and Disinfection

The DOI matches its Crossref record; 13 of the 14 references it cites were found in a registry or an index.

Room Decontamination with UV Radiation

Rutala, William A., Gergen, Maria F., Weber, David J.·2010·Infection Control & Hospital Epidemiology
DOI 10.1086/656244
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Abstract

OBJECTIVE: To determine the effectiveness of a UV-C-emitting device to eliminate clinically important nosocomial pathogens in a contaminated hospital room. METHODS: This study was carried out in a standard but empty hospital room (phase 1) and in a room previously occupied by a patient with methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) infection (phase 2) in an acute care tertiary hospital in North Carolina from January 21 through September 21, 2009. During phase 1, 8 x 8 cm Formica sheets contaminated with approximately 10(4)-10(5) organisms of MRSA, VRE, multidrug-resistant (MDR) Acinetobacter baumannii, or Clostridium difficile spores were placed in a hospital room, both in direct line of sight of the UV-C device and behind objects. After timed exposure, the presence of the microbes was assessed. During phase 2, specific sites in rooms that had housed patients with MRSA or VRE infection were sampled before and after UV-C irradiation. After timed exposure, the presence of MRSA and VRE and total colony counts were assessed. RESULTS: In our test room, the effectiveness of UV-C radiation in reducing the counts of vegetative bacteria on surfaces was more than 99.9% within 15 minutes, and the reduction in C. difficile spores was 99.8% within 50 minutes. In rooms occupied by patients with MRSA, UV-C irradiation of approximately 15 minutes duration resulted in a decrease in total CFUs per plate (mean, 384 CFUs vs 19 CFUs; P < .001), in the number of samples positive for MRSA (81 [20.3%] of 400 plates vs 2 [0.5%] of 400 plates; P < .001), and in MRSA counts per MRSA-positive plate (mean, 37 CFUs vs 2 CFUs; P < .001). CONCLUSIONS: This UV-C device was effective in eliminating vegetative bacteria on contaminated surfaces both in the line of sight and behind objects within approximately 15 minutes and in eliminating C. difficile spores within 50 minutes.

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Crossref · 10.1086/656244

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Research works printed but not linked: 3

  1. Rutala, 2009, APIC Text of Infection Control and Epidemiology, 21, 1
  2. Blatchley, 2001, Disinfection, Sterilization and Preservation, 823
  3. Shaughnessy, 2008, Programs and abstracts of the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy/Infections Disease Society of America 46th Annual Meeting

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Metadata

Authors
Rutala, W. A., Gergen, M. F., & Weber, D. J.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Rutala, William A.
ORCID
Weber, David J.
Venue
Infection Control & Hospital Epidemiology
Publisher
Cambridge University Press (CUP)
Published
2010-10
Volume
31
Issue
10
Pages
1025-1029
ISSN
  • 0899-823X (ISSN-L)
  • 1559-6834
DOI
10.1086/656244
OpenAlex
W2143825991
Cited by
221
References
14
Citations by year
2026: 9 · 2025: 4 · 2024: 17 · 2023: 21 · 2022: 14 · 2021: 13 · 2020: 15 · 2019: 15 · 2018: 13 · 2017: 14 · 2016: 16 · 2015: 14 · 2014: 17 · 2013: 19 · 2012: 10
FWCI
8.00
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 1554 d)
Locations
  • Infection Control and Hospital Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • Infection Control and Hospital Epidemiology
Funders
U.S. Public Health Service (1ULRR025747-01)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Infection Control and Ventilation
  • Life Sciences › Immunology and Microbiology › Microbiology › Medical Device Sterilization and Disinfection
Keywords
UV-C disinfection, nosocomial pathogens, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, Acinetobacter baumannii, multidrug-resistant bacteria, surface decontamination, hospital room disinfection
MeSH terms
Bacteria, Bacterial Infections, Cross Infection, Decontamination, Hospitals, Humans, North Carolina, Patients' Rooms, Ultraviolet Rays, Colony Count, Microbial, Clostridioides difficile, Enterococcus, Methicillin-Resistant Staphylococcus aureus

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