The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy

Both Doornbos et al. and Meglinski and Matcher present optical coefficients for FST I-II skin.

“Both of these publications present optical coefficients for FST I–II skin.”

Publications by Doornbos et al. and Meglinski and Matcher were the most cited with 673 and 544 citations, respectively.

“Publications by Doornbos et al.38 and Meglinski and Matcher43 were the most cited with 673 and 544 citations, respectively.”

In Doornbos et al., at 630 nm absorption was greatest in the forehead compared to the sole of the foot and the arm; at 660 nm it was greatest in the sole of the foot; at 700 nm the arm had greatest absorption.

“Wavelength measurements were limited to 630 nm, 660 nm and 700 nm and at 630 nm absorption was greatest in the forehead compared to the sole of the foot and the arm. At 660 nm it was greatest in the sole of the foot, and at 700 nm the arm had greatest absorption.”

Scattering was greatest in the forehead and least in the arm at 630, 660, and 700 nm (Doornbos et al.).

“However, scattering was greatest in the forehead and least in the arm at each of these wavelengths.”

Skin location has an important effect on absorption and scattering coefficients (Doornbos et al.).

“Like Tseng et al., skin location was shown to have an important effect on absorption and scattering coefficients by Doornbos et al. [55,57].”

Measured reduced scattering coefficients have up to 10-fold variability using DRS at 700 nm, ranging from 0.184 mm-1 to 2.19 mm-1.

“Similarly, measured reduced scattering coefficients have up to 10-fold variability using DRS at this wavelength, ranging from 0.184 mm-1 to 2.19 mm-1 [55,57,60,61].”

In agreement with Doornbos et al., the forehead was the location of greatest scattering amongst the subjects and the arm the least.

“In agreement with Doornbos et al., the forehead was the location of greatest scattering amongst the subjects and the arm the least [57].”

Numerous authors have measured optical properties of skin on the forearm using DRS and absorption coefficients vary 9-fold amongst publications from 0.01 mm-1 to 0.09 mm-1 at 700 nm.

“Numerous authors have measured the optical properties of skin on the forearm using DRS and the absorption coefficients vary 9-fold amongst the publications from 0.01 mm-1 - 0.09 mm-1 at 700 nm [37,46,55,57,60].”