Cited by 64Advanced Neuroimaging Techniques and ApplicationsAdvanced MRI Techniques and ApplicationsNMR spectroscopy and applications

The design of anisotropic diffusion phantoms for the validation of diffusion weighted magnetic resonance imaging

Open access
Fieremans, Els, De Deene, Yves, Delputte, Steven, Özdemir, Mahir S, Achten, Eric, Lemahieu, Ignace·2008·Physics in Medicine and Biology

Abstract

Diffusion weighted magnetic resonance imaging offers a non-invasive tool to explore the three-dimensional structure of brain white matter in clinical practice. Anisotropic diffusion hardware phantoms are useful for the quantitative validation of this technique. This study provides guidelines on how to manufacture anisotropic fibre phantoms in a reproducible way and which fibre material to choose to obtain a good quality of the diffusion weighted images. Several fibre materials are compared regarding their effect on the diffusion MR measurements of the water molecules inside the phantoms. The diffusion anisotropy influencing material properties are the fibre density and diameter, while the fibre surface relaxivity and magnetic susceptibility determine the signal-to-noise ratio. The effect on the T(2)-relaxation time of water in the phantoms has been modelled and the diffusion behaviour inside the fibre phantoms has been quantitatively evaluated using Monte Carlo random walk simulations.

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  • Ex vivo imaging and tracing or physically and numerically simulated phantoms allow validation to some extent, and in specific circumstances such as basic fiber configurations.

    “Ex vivo imaging and tracing17–23 or physically24–30 and numerically simulated phantoms31–34 allow validation to some extent, and in specific circumstances such as basic fiber configurations.”

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Research works printed but not linked: 7

  1. Cho K, Yeh C, Chao Y, Chen J and Lin C 2006 Accuracy assessment of q-ball imaging with phantom models Proc. ISMRM 14th Scientific Meeting (Seattle, USA) p 642
  2. Laun F B, Stieltjes B, Huff S and Schad L R 2007 Investigation of a DTI-phantom with properties similar to in vivo neuronal tissue Proc. ISMRM 15th Scientific Meeting (Berlin, Germany) p 1526
  3. Lorenz R, Kreher B W, Hennig J, Belleman M E and Il'Yasov K A 2006 Anisotropic fiber phantom for DTI validation on a clinical scanner Proc. ISMRM 14th Scientific Meeting (Seattle, USA) p 2738
  4. Poupon C, Rieul B, Perrin M, Mangin J F and Le Bihan D 2007 New diffusion phantoms dedicated to study and validation of Hardi diffusion models Proc. ISMRM 15th Scientific Meeting (Berlin, Germany) p 907
  5. Pullens W L, Roebroeck A and Goebel R 2007 Kissing or crossing: validation of DTI tractography in ground truth hardware phantoms Proc. ISMRM 15th Scientific Meeting (Berlin, Germany) p 1479
  6. Raguin L G, Hernando D, Karampinos D, Ciobanu L, Sutton B P, Liang Z P and Georgiadis J G 2006 Quantitative analysis of q-space MRI data: theoretical and experimental validation Proc. ISMRM 14th Scientific Meeting (Seattle, USA) p 2729
  7. Reischauer C, Staempfli P, Jaermann T, Kollias S and Boesiger P 2007 Development of a temperature controlled anisotropic diffusion phantom Proc. ISMRM 15th Scientific Meeting (Berlin, Germany) p 3535

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Authors
Fieremans, E., De Deene, Y., Delputte, S., Özdemir, M. S., Achten, E., & Lemahieu, I.
Affiliations
  • Ghent University (BE)
  • Ghent University Hospital (BE)
Venue
Physics in Medicine and Biology
Published
2008-09-02
Volume
53
Issue
19
Pages
5405-5419
ISSN
  • 0031-9155 (ISSN-L)
  • 1361-6560
OpenAlex
W1987747076
Cited by
64
References
50
Citations by year
2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 13 · 2016: 3 · 2015: 7 · 2013: 4 · 2012: 4
FWCI
2.05
Type
journal article
Language
en
Open access
Locations
  • Physics in Medicine and Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders
  • Belgische Federale Overheidsdiensten
  • Vlaamse regering
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
Keywords
diffusion-weighted imaging, white matter, phantom design, fiber density, fiber diameter, surface relaxivity, magnetic susceptibility, T2 relaxation, signal-to-noise ratio, diffusion anisotropy, quantitative validation
MeSH terms
Diffusion, Magnetics, Surface Properties, Time Factors, Water, Reproducibility of Results, Anisotropy, Phantoms, Imaging, Diffusion Magnetic Resonance Imaging

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