The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Gold nanoparticle sensitize radiotherapy of prostate cancer cells by regulation of the cell cycle
Abstract
Glucose-capped gold nanoparticles (Glu-GNPs) have been used to improve cellular targeting and radio-sensitization. In this study, we explored the mechanism of Glu-GNP enhanced radiation sensitivity in radiation-resistant human prostate cancer cells. Cell survival and proliferation were measured using MTT and clonogenic assay. Flow cytometry with staining by propidium iodide (PI) was performed to study the cell cycle changes induced by Glu-GNPs, and western blotting was used to determine the expression of p53 and cyclin proteins that correlated to cell cycle regulation. With 2 Gy of ortho-voltage irradiation, Glu-GNP showed a 1.5-2.0 fold enhancement in growth inhibition when compared to x-rays alone. Comparing the cell cycle change, Glu-GNPs induced acceleration in the G0/G1 phase and accumulation of cells in the G2/M phase at 29.8% versus 18.4% for controls at 24 h. G2/M arrest was accompanied by decreased expression of p53 and cyclin A, and increased expression of cyclin B1 and cyclin E. In conclusion, Glu-GNPs trigger activation of the CDK kinases leading to cell cycle acceleration in the G0/G1 phase and accumulation in the G2/M phase. This activation is accompanied by a striking sensitization to ionizing radiation, which may have clinical implications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
O'Neal, D. P., Hirsch, L. R., Halas, N. J., Payne, J. D., & West, J. L. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.02.004 · Cited by 1,849
The use of gold nanoparticles to enhance radiotherapy in mice
Hainfeld, J. F., Slatkin, D. N., & Smilowitz, H. M. (2004) · Physics in Medicine and Biology · doi:10.1088/0031-9155/49/18/n03 · Cited by 1,638
Jordan, A., Scholz, R., Wust, P., Fähling, H., & Felix, R. (1999) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(99)00088-8 · Cited by 1,494
Cyclin A is required at two points in the human cell cycle.
Pagano, M., Pepperkok, R., Verde, F., Ansorge, W., & Draetta, G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05135.x · Cited by 1,403
Gold nanoparticles: a new X-ray contrast agent
Hainfeld, J. F., Slatkin, D. N., Focella, T. M., & Smilowitz, H. M. (2006) · The British Journal of Radiology · doi:10.1259/bjr/13169882 · Cited by 1,351
Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents
Chen, J., Saeki, F., Wiley, B. J., Cang, H., Cobb, M. J., Li, Z.-Y., Au, L., Zhang, H., Kimmey, M. B., Li, X., et al. (2005) · Nano Letters · doi:10.1021/nl047950t · Cited by 977
Self-citationZou, H., McGarry, T. J., Bernal, T., & Kirschner, M. W. (1999) · Science · doi:10.1126/science.285.5426.418 · Cited by 805
Variations in Several Responses of HeLa Cells to X-Irradiation during the Division Cycle
Terasima, T., & Tolmach, L. J. (1963) · Biophysical Journal · doi:10.1016/s0006-3495(63)86801-0 · Cited by 578
Cell selective response to gold nanoparticles
Patra, H. K., Banerjee, S., Chaudhuri, U., Lahiri, P., & Dasgupta, A. K. (2007) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2007.03.005 · Cited by 456
Emi1 Is a Mitotic Regulator that Interacts with Cdc20 and Inhibits the Anaphase Promoting Complex
Reimann, J. D. R., Freed, E., Hsu, J. Y., Kramer, E. R., Peters, J.-M., & Jackson, P. K. (2001) · Cell · doi:10.1016/s0092-8674(01)00361-0 · Cited by 389
Cited by
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Her, S., Jaffray, D. A., & Allen, C. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.012 · Cited by 865
Recent Advances in Metal Decorated Nanomaterials and Their Various Biological Applications: A Review
Yaqoob, A. A., Ahmad, H., Parveen, T., Ahmad, A., Oves, M., Ismail, I. M. I., Qari, H. A., Umar, K., & Mohamad Ibrahim, M. N. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00341 · Cited by 718
Gold Nanoparticles in Cancer Treatment
Sztandera, K., Gorzkiewicz, M., & Klajnert-Maculewicz, B. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00810 · Cited by 607
Physical basis and biological mechanisms of gold nanoparticle radiosensitization
Butterworth, K. T., McMahon, S. J., Currell, F. J., & Prise, K. M. (2012) · Nanoscale · doi:10.1039/c2nr31227a · Cited by 478
Recent advances in metal nanoparticles in cancer therapy
Sharma, A., Goyal, A. K., & Rath, G. (2018) · Journal of Drug Targeting · doi:10.1080/1061186x.2017.1400553 · Cited by 341
Metadata
- Authors
- Roa, W., Zhang, X., Guo, L., Shaw, A., Hu, X., Xiong, Y., Gulavita, S., Patel, S., Sun, X., Chen, J., Moore, R., & Xing, J. Z.
- Venue
- Nanotechnology
- Publisher
- IOP Publishing
- Published
- 2009-08-26
- Volume
- 20
- Issue
- 37
- Pages
- 375101
- ISSN
- 0957-4484 (ISSN-L)
- 1361-6528
- OpenAlex
- W2003959927
- Cited by
- 314
- References
- 25
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Gold nanoparticle sensitize radiotherapy of prostate cancer cells by regulation of the cell cycle. https://app.cochat.ai/papers/10.1088/0957-4484/20/37/375101
- The paper
- Roa, W., Zhang, X., Guo, L., Shaw, A., Hu, X., Xiong, Y., Gulavita, S., Patel, S., Sun, X., Chen, J., Moore, R., & Xing, J. Z. (2009). Gold nanoparticle sensitize radiotherapy of prostate cancer cells by regulation of the cell cycle. Nanotechnology. https://doi.org/10.1088/0957-4484/20/37/375101
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
