The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T 1 - and T 2 -weighted magnetic resonance imaging
Abstract
The development of new types of high-performance nanoparticulate MR contrast agents with either positive (T(1)) or dual-contrast (both positive and negative, T(1) + T(2)) ability is of great importance. Here we report a facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T(1)- and T(2)-weighted MRI. The produced superparamagnetic iron oxide nanoparticles (SPIONs) are of high crystallinity and size uniformity with an average diameter of 5.4 nm, and can be individually dispersed in the physiological buffer with high stability. The SPIONs reveal an impressive saturation magnetization of 94 emu g(-1) Fe(3)O(4), the highest r(1) of 19.7 mM(-1) s(-1) and the lowest r(2)/r(1) ratio of 2.0 at 1.5 T reported so far for PEGylated iron oxide nanoparticles. T(1)- and T(2)-weighted MR images showed that the SPIONs could not only improve surrounding water proton signals in the T(1)-weighted image, but induce significant signal reduction in the T(2)-weighted image. The good contrast effect of the SPIONs as T(1) + T(2) dual-contrast agents might be due to its high magnetization, optimal nanoparticle size for T(1) + T(2) dual-contrast agents, high size monodispersity and excellent colloidal stability. In vitro cell experiments showed that the SPIONs have little effect on HeLa cell viability.
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“In addition, the organic shell surrounding the core needs to be stable under physiological conditions and it needs to prevent the aggregation of individual nanoparticles, as this would result in an undesired T2 contrast enhancement [141, 142].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [142]
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy
Lee, N., Yoo, D., Ling, D., Cho, M. H., Hyeon, T., & Cheon, J. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00112 · Cited by 1,020
Kim, B. H., Lee, N., Kim, H., An, K., Park, Y. I., Choi, Y., Shin, K., Lee, Y., Kwon, S. G., Na, H. B., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja203340u · Cited by 957
Jeon, M., Halbert, M. V., Stephen, Z. R., & Zhang, M. (2020) · Advanced Materials · doi:10.1002/adma.201906539 · Cited by 497
Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications
Zhao, N., Yan, L., Zhao, X., Chen, X., Li, A., Zheng, D., Zhou, X., Dai, X., & Xu, F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00401 · Cited by 431
Metadata
- Authors
- Hu, F., Jia, Q., Li, Y., & Gao, M.
- Affiliations
- Beijing Normal University (CN)
- Chinese Academy of Sciences (CN)
- Venue
- Nanotechnology
- Publisher
- IOP Publishing
- Published
- 2011-04-21
- Volume
- 22
- Issue
- 24
- Pages
- 245604
- ISSN
- 0957-4484 (ISSN-L)
- 1361-6528
- OpenAlex
- W2037035194
- Cited by
- 147
- References
- 41
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 10 · 2019: 10 · 2018: 10 · 2017: 13 · 2016: 17 · 2015: 16 · 2014: 15 · 2013: 9 · 2012: 7
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Beijing Normal University
- Fundamental Research Funds for the Central Universities
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Keywords
- superparamagnetic iron oxide nanoparticles, T1-weighted imaging, T2-weighted imaging, MRI contrast agents, nanoparticle synthesis, saturation magnetization, colloidal stability
- MeSH terms
- Cell Survival, Contrast Media, Ferric Compounds, HeLa Cells, Humans, Magnetic Resonance Imaging, Magnetics, Particle Size, Polyethylene Glycols, X-Ray Diffraction, Spectroscopy, Fourier Transform Infrared, Nanotechnology, Nanoparticles
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