Cited by 147Characterization and Applications of Magnetic NanoparticlesAdvanced MRI Techniques and ApplicationsLanthanide and Transition Metal Complexes

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Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T 1 - and T 2 -weighted magnetic resonance imaging

Hu, Fengqin, Jia, Qiaojuan, Li, Yilin, Gao, Mingyuan·2011·Nanotechnology

DOI 10.1088/0957-4484/22/24/245604

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Abstract

The development of new types of high-performance nanoparticulate MR contrast agents with either positive (T(1)) or dual-contrast (both positive and negative, T(1) + T(2)) ability is of great importance. Here we report a facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T(1)- and T(2)-weighted MRI. The produced superparamagnetic iron oxide nanoparticles (SPIONs) are of high crystallinity and size uniformity with an average diameter of 5.4 nm, and can be individually dispersed in the physiological buffer with high stability. The SPIONs reveal an impressive saturation magnetization of 94 emu g(-1) Fe(3)O(4), the highest r(1) of 19.7 mM(-1) s(-1) and the lowest r(2)/r(1) ratio of 2.0 at 1.5 T reported so far for PEGylated iron oxide nanoparticles. T(1)- and T(2)-weighted MR images showed that the SPIONs could not only improve surrounding water proton signals in the T(1)-weighted image, but induce significant signal reduction in the T(2)-weighted image. The good contrast effect of the SPIONs as T(1) + T(2) dual-contrast agents might be due to its high magnetization, optimal nanoparticle size for T(1) + T(2) dual-contrast agents, high size monodispersity and excellent colloidal stability. In vitro cell experiments showed that the SPIONs have little effect on HeLa cell viability.

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Authors: Hu, F., Jia, Q., Li, Y., & Gao, M.
Affiliations: Beijing Normal University (CN)
Chinese Academy of Sciences (CN)
ORCID: Hu, Fengqin
Li, Yilin
Gao, Mingyuan
Venue: Nanotechnology
Publisher: IOP Publishing
Published: 2011-04-21
Volume: 22
Issue: 24
Pages: 245604
ISSN: 0957-4484 (ISSN-L)
1361-6528
DOI: 10.1088/0957-4484/22/24/245604
OpenAlex: W2037035194
Cited by: 147
References: 41
Citations by year: 2026: 5 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 10 · 2019: 10 · 2018: 10 · 2017: 13 · 2016: 17 · 2015: 16 · 2014: 15 · 2013: 9 · 2012: 7
FWCI: 6.25
Type: journal article
Language: en
Open access: closed
Locations: Nanotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: Beijing Normal University
Fundamental Research Funds for the Central Universities
Topics: Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
Keywords: superparamagnetic iron oxide nanoparticles, T1-weighted imaging, T2-weighted imaging, MRI contrast agents, nanoparticle synthesis, saturation magnetization, colloidal stability
MeSH terms: Cell Survival, Contrast Media, Ferric Compounds, HeLa Cells, Humans, Magnetic Resonance Imaging, Magnetics, Particle Size, Polyethylene Glycols, X-Ray Diffraction, Spectroscopy, Fourier Transform Infrared, Nanotechnology, Nanoparticles

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Facile synthesis of ultrasmall PEGylated iron oxide nanoparticles for dual-contrast T 1 - and T 2 -weighted magnetic resonance imaging

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