Cited by 206Characterization and Applications of Magnetic NanoparticlesMagnetic Properties and Synthesis of FerritesGeomagnetism and Paleomagnetism Studies

Aggregation effects on the magnetic properties of iron oxide colloids

Open access
Gutiérrez, Lucía, de la Cueva, Leonor, Moros, María, Mazarío, Eva, de Bernardo, Sara, de la Fuente, Jesús M, Morales, M Puerto, Salas, Gorka·2019·Nanotechnology

Abstract

Magnetic nanoparticles (MNPs), and in particular iron oxide nanoparticles (mainly magnetite and maghemite), are being widely used in the form of aqueous colloids for biomedical applications. In such colloids, nanoparticles tend to form assemblies, either aggregates, if the union is permanent, or agglomerates, if it is reversible. These clustering processes have a strong impact on the MNPs’ properties that are often not well understood. In this review, the causes and consequences of MNPs aggregation/agglomeration are reviewed and discussed. Special attention has been paid to the impact of the MNPs aggregation/agglomeration on their magnetic properties and heating properties, when exposed to an alternating magnetic field in the frame of magnetic hyperthermia. In addition, a model system with MNPs of two different sizes coated with three different molecules oleic acid, meso-2, 3-dimercaptosuccinic acid and poly(maleic anhydride-alt-1-octadecene) has been characterized and the results used to support the ideas reviewed.

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  • Bare magnetite MNPs tend to form aggregates or agglomerates and have poor selectivity towards analytes.

    “Nevertheless, bare MNPs based on magnetite possess few drawbacks such as (i) they tend to form assemblies, either aggregates, if the union is permanent, or agglomerates, if it is reversible [16], and (ii) poor selectivity towards the analyte [17].”

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Research works printed but not linked: 3

  1. A recent review on MNPs coated with DMSA for biomedical applications can be found in:
  2. Song, H. T.; Choi, J. S.; Huh, Y. M.; Kim, S.; Jun, Y. W.; Sun, J. S.; Cheon, J. Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling. J. Am. Chem. Soc. 2005, 127, 9992-9993.
  3. Sun, J.; Fan, F.; Wang, P.; Ma, S.; Song, L.; Gu, N. Orientation-Dependent Thermogenesis of Assembled Magnetic Nanoparticles in the Presence of an Alternating Magnetic Field. ChemPhysChem 2016, 17, 3377-3384.

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Authors
Gutiérrez, L., de la Cueva, L., Moros, M., Mazarío, E., de Bernardo, S., de la Fuente, J. M., Morales, M. P., & Salas, G.
Affiliations
  • Consejo Superior de Investigaciones Científicas (ES)
  • Madrid Institute for Advanced Studies (ES)
Corresponding author
Salas, Gorka
Venue
Nanotechnology
Published
2019-01-22
Volume
30
Issue
11
Pages
112001
ISSN
  • 0957-4484 (ISSN-L)
  • 1361-6528
OpenAlex
W2907912678
Cited by
206
References
95
Citations by year
2026: 14 · 2025: 25 · 2024: 40 · 2023: 25 · 2022: 33 · 2021: 33 · 2020: 24 · 2019: 10
FWCI
8.82
Type
journal article
Language
en
Open access
Locations
  • Nanotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • Zaguan (Universidad de Zaragoza) (submittedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders
  • Comunidad de Madrid (NANOFRONTMAG-CM)
  • Ministerio de Economía y Competitividad (Grant SEV-2016-0686)
  • European Commission (ERC-Starting Grant 239931-NANOPUZZLE)
  • Diputación General de Aragón (BIONANOSURF)
  • Secretaría de Estado de Investigación, Desarrollo e Innovación (RYC-2014-15512)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Geomagnetism and Paleomagnetism Studies
Keywords
iron oxide nanoparticles, magnetic nanoparticles, nanoparticle aggregation, agglomeration, magnetic properties, magnetic hyperthermia, alternating magnetic field heating, magnetite, maghemite, oleic acid coating, meso-2,3-dimercaptosuccinic acid, poly(maleic anhydride-alt-1-octadecene), nanoparticle assembly, biomedical applications

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