Bio-based hyperbranched polyurethane/Fe 3 O 4 nanocomposites: smart antibacterial biomaterials for biomedical devices and implants
Open accessAbstract
The fabrication of a smart magnetically controllable bio-based polymeric nanocomposite (NC) has immense potential in the biomedical domain. In this context, magneto-thermoresponsive sunflower oil modified hyperbranched polyurethane (HBPU)/Fe3O4 NCs with different wt.% of magnetic nanoparticles (Fe3O4) were prepared by an in situ polymerization technique. Fourier-transform infrared, x-ray diffraction, vibrating sample magnetometer, scanning electron microscope, transmission electron microscope, thermal analysis and differential scanning calorimetric were used to analyze various physico-chemical structural attributes of the prepared NC. The results showed good interfacial interactions between HBPU and well-dispersed superparamagnetic Fe3O4, with an average diameter of 7.65 nm. The incorporation of Fe3O4 in HBPU significantly improved the thermo-mechanical properties along with the shape-memory behavior, antibacterial activity, biocompatibility as well as biodegradability in comparison to the pristine system. The cytocompatibility of the degraded products of the NC was also verified by in vitro hemolytic activity and MTT assay. In addition, the in vivo biocompatibility and non-immunological behavior, as tested in Wistar rats after subcutaneous implantation, show promising signs for the NC to be used as antibacterial biomaterial for biomedical device and implant applications.
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The biocompatible nanocomposites (Fe3O4 content 15 wt%) exhibited excellent antimicrobial activity, prevented the biofilm formation against Staphylococcus aureus and Klebsiella pneumoniae and had a good cytocompatibility with different cells lines.
“Moreover, the biocompatible nanocomposites (Fe3O4 content of 15 wt%) exhibited excellent antimicrobial activity, prevented the biofilm formation against Staphylococcus aureus and Klebsiella pneumoniae and had a good cytocompatibility with different cells lines.”
From Shape-memory polymers for multiple applications in the materials world (2016) · cites this paper as [168]
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Experimental — accuracy not yet measuredBased on the obtained results the materials were classified as suitable for biomedical applications (magnetically controlled smart implants and tissue engineering scaffolds).
“Based on the obtained results the materials were classified as suitable for biomedical applications (magnetically controlled smart implants and tissue engineering scaffolds).”
From Shape-memory polymers for multiple applications in the materials world (2016) · cites this paper as [168]
The Conclusion recommends the nanocomposite for biomedical use as a thermally and magnetically controlled smart biomaterial, and the Introduction describes its potential for implantation. The Introduction mentions tissue engineering as an application of magnetic nanoparticles generally, but our copy does not identify the studied nanocomposite as a suitable tissue-engineering scaffold. Page numbers were not available in the indexed passages. (LLM, conf=0.87)
Experimental — accuracy not yet measuredFe3O4 in SMPs could be used as an effective nanofiller for the generation of gradual hydrolysis degradation of sunflower oil modified HPU/Fe3O4 materials.
“Fe3O4 in SMPs could be used not only as nanoreinforced agent as well as an effective nanofiller for the generation of gradual hydrolysis degradation of sunflower oil modified HPU/Fe3O4 materials [168].”
From Shape-memory polymers for multiple applications in the materials world (2016) · cites this paper as [168]
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Self-citation
- Authors
- Das, B., Mandal, M., Upadhyay, A., Chattopadhyay, P., & Karak, N.
- Affiliations
- Tezpur University (IN)
- Defence Research Laboratory (IN)
- Corresponding author
- Karak, Niranjan
- Venue
- Biomedical Materials
- Publisher
- IOP Publishing
- Published
- 2013-03-26
- Volume
- 8
- Issue
- 3
- Pages
- 035003
- ISSN
- 1748-6041 (ISSN-L)
- 1748-605X
- OpenAlex
- W2161923315
- Cited by
- 122
- References
- 41
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 12 · 2023: 9 · 2022: 8 · 2021: 14 · 2020: 7 · 2019: 13 · 2018: 8 · 2017: 12 · 2016: 13 · 2015: 4 · 2014: 11 · 2013: 3
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biomedical Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hubei Polytechnic University
- Topics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- hyperbranched polyurethane, Fe3O4 nanoparticles, magnetic nanocomposites, sunflower oil, antibacterial biomaterials, shape memory behavior, thermomechanical properties, biocompatibility, biodegradability, cytocompatibility, hemolytic activity, superparamagnetic iron oxide nanoparticles, biomedical implants, in situ polymerization, in vivo implantation
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacterial Adhesion, Biocompatible Materials, Biomechanical Phenomena, Equipment and Supplies, Materials Testing, Polyurethanes, Molecular Structure, Rats, Wistar, Prostheses and Implants, Absorbable Implants, Rats, Nanocomposites, Magnetite Nanoparticles
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