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Evaluation of novel in situ synthesized nano-hydroxyapatite/collagen/alginate hydrogels for osteochondral tissue engineering
Open accessAbstract
Collagen hydrogel has been widely used for osteochondral repair, but its mechanical properties cannot meet the requirements of clinical application. Previous studies have shown that the addition of either polysaccharide or inorganic particles could reinforce the polymer matrix. However, their synergic effects on collagen-based hydrogel have seldom been studied, and the potential application of triple-phased composite gel in osteochondral regeneration has not been reported. In this study, nano-hydroxyapatite (nano-HA) reinforced collagen-alginate hydrogel (nHCA) was prepared by the in situ synthesis of nano-HA in collagen gel followed by the addition of alginate and Ca(2+). The properties of triple-phased nHCA hydrogel were studied and compared with pure collagen and biphasic gels, and the triple-phased composite of collagen-alginate-HA gels showed a superiority in not only mechanical but also biological features, as evidenced by the enhanced tensile and compressive modulus, higher cell viability, faster cell proliferation and upregulated hyaline cartilage markers. In addition, it was found that the synthesis process could also affect the properties of the triple-phased composite, compared to blend-mixing HCA. The in situ-synthesized nHCA hydrogel showed an enhanced tensile modulus, as well as enhanced biological features compared with HCA. Our study demonstrated that the nHCA composite hydrogel holds promise in osteochondral regeneration. The addition of alginate and nano-HA contribute to the increase in both mechanical and biological properties. This study may provide a valuable reference for the design of an appropriate composite scaffold for osteochondral tissue engineering.
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Nano-sized particles are capable of serving as pro-adhesive agents.
“Reports validate that the nano sized particles are capable of serving as pro-adhesive agents [55].”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [55]
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Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
Kavitha Sri, A., Arthi, C., Neya, N. R., & Hikku, G. S. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99e · Cited by 57
Metadata
- Authors
- Zheng, L., Jiang, X., Chen, X., Fan, H., & Zhang, X.
- Affiliations
- Guangxi Medical University (CN)
- Sichuan University (CN)
- Corresponding author
- Zhang, Xingdong
- Venue
- Biomedical Materials
- Publisher
- IOP Publishing
- Published
- 2014-10-30
- Volume
- 9
- Issue
- 6
- Pages
- 065004
- ISSN
- 1748-6041 (ISSN-L)
- 1748-605X
- OpenAlex
- W2069937122
- Cited by
- 59
- References
- 41
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 5 · 2016: 11 · 2015: 5
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-08-02)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biomedical Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- osteochondral tissue engineering, hydroxyapatite nanoparticles, in situ synthesis, mechanical reinforcement, cartilage regeneration, chondrocyte proliferation, composite scaffolds
- MeSH terms
- Alginates, Animals, Biocompatible Materials, Bone and Bones, Cell Survival, Collagen, Microscopy, Electron, Scanning, Osteogenesis, Rabbits, Regeneration, Stress, Mechanical, Ultrasonics, Durapatite, DNA Primers, Microscopy, Confocal, Chondrocytes, Hydrogels, Tissue Engineering, Cell Proliferation, Tissue Scaffolds
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