The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Bioglass incorporated methacrylated collagen bioactive ink for 3D printing of bone tissue
Open accessAbstract
Bioactive three-dimensional (3D) printed scaffolds are promising candidates for bone tissue engineering (BTE) applications. Here, we introduce a bioactive ink composed of Bioglass 45S5 (BG) and methacrylated collagen (CMA) for 3D printing of biomimetic constructs that resemble the organic and inorganic composition of native bone tissue. A uniform dispersion of BG particles within the collagen network improved stability and reduced swelling of collagen hydrogels. Rheological testing showed significant improvement in the yield stress and percent recovery of 3D printed constructs upon BG incorporation. Further, addition of BG improved the bone bioactivity of 3D printed constructs in stimulated body fluid. BG incorporated CMA (BG-CMA) constructs maintained high cell viability and enhanced alkaline phosphatase activity of human mesenchymal stem cells. In addition, cell-mediated calcium deposition was significantly higher on BG-CMA constructs, compared to CMA alone. In conclusion, 3D printed BG-CMA constructs have significant potential for use in BTE applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“Nevertheless, despite these improvements, ColMA-based hydrogels still exhibit insufficient mechanical robustness, limiting their ability to maintain dimensional accuracy during extrusion-based bioprinting [15,16].”
From Montmorillonite-reinforced methacrylated collagen/methacrylated silk fibroin hydrogel-based inks: rheological and physicochemical characterization for bone scaffold applications (2026) · cites this paper as [15]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
How useful is SBF in predicting in vivo bone bioactivity?
Kokubo, T., & Takadama, H. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.01.017 · Cited by 9,578
3D bioprinting of tissues and organs
Murphy, S. V., & Atala, A. (2014) · Nature Biotechnology · doi:10.1038/nbt.2958 · Cited by 7,034
Bone tissue engineering using 3D printing
Bose, S., Vahabzadeh, S., & Bandyopadhyay, A. K. (2013) · Materials Today · doi:10.1016/j.mattod.2013.11.017 · Cited by 1,873
Hinton, T. J., Jallerat, Q., Palchesko, R. N., Park, J. H., Grodzicki, M. S., Shue, H.-J., Ramadan, M. H., Hudson, A. R., & Feinberg, A. W. (2015) · Science Advances · doi:10.1126/sciadv.1500758 · Cited by 1,805
Current advances and future perspectives in extrusion-based bioprinting
Ozbolat, I. T., & Hospodiuk, M. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.076 · Cited by 1,642
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Escott-Price, V., Bellenguez, C., Wang, L.-S., Choi, S.-H., Harold, D., Jones, L., Holmans, P., Gerrish, A., Vedernikov, A., Richards, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094661 · Cited by 1,398
Leong, K. F., Cheah, C. M., & Chua, C. K. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00030-9 · Cited by 1,090
3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances
Derakhshanfar, S., Mbeleck, R., Xu, K., Zhang, X., Zhong, W., & Xing, M. M. Q. (2018) · Bioactive Materials · doi:10.1016/j.bioactmat.2017.11.008 · Cited by 1,073
Woodard, J. R., Hilldore, A. J., Lan, S. K., Park, C. J., Whittington, A. R., Eurell, J. A. C., Clark, S. G., Wheeler, M. B., Jamison, R. D., & Johnson, A. J. W. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.08.021 · Cited by 829
Cited by
Sorted by citations
Ding, A., Tang, F., & Alsberg, E. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00070 · Cited by 194
Embedded bioprinting for designer 3D tissue constructs with complex structural organization
Zeng, X., Meng, Z., He, J., Mao, M., Li, X., Chen, P., Fan, J., & Li, D. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.11.048 · Cited by 90
Nanocomposite Bioprinting for Tissue Engineering Applications
Loukelis, K., Helal, Z. A., Mikos, A. G., & Chatzinikolaidou, Μ. (2023) · Gels · doi:10.3390/gels9020103 · Cited by 79
Collagen as a bio-ink for 3D printing: a critical review
Debnath, S., Agrawal, A., Jain, N., Chatterjee, K., & Player, D. J. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb01060d · Cited by 71
Biomimetic reduced graphene oxide coated collagen scaffold for in situ bone regeneration
Bahrami, S., Baheiraei, N., & Shahrezaee, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-96271-1 · Cited by 68
Additive manufacturing of bioactive glass biomaterials
Simorgh, S., Alasvand, N., Khodadadi, M., Ghobadi, F., Kebria, M. M., Milan, P. B., Kargozar, S., Baino, F., Mobasheri, A., & Mozafari, M. (2022) · Methods · doi:10.1016/j.ymeth.2022.10.010 · Cited by 67
O'Shea, D. G., Curtin, C. M., & O’Brien, F. J. (2022) · Biomaterials Science · doi:10.1039/d1bm01540k · Cited by 59
Gholami, K., Ege, F., & Barzegar, R. (2023) · Journal of Composites Science · doi:10.3390/jcs7020054 · Cited by 48
3D printing of biomedical materials and devices
Bandyopadhyay, A. K., Ghosh, S., Boccaccini, A. R., & Bose, S. (2021) · Journal of materials research/Pratt's guide to venture capital sources · doi:10.1557/s43578-021-00407-y · Cited by 43
Shokrollahi, Y., Dong, P., Gamage, P. T., Patrawalla, N. Y., Kishore, V., Mozafari, H., & Gu, L. (2022) · Applied Sciences · doi:10.3390/app122110835 · Cited by 40
Self-citationBioactive Inks Development for Osteochondral Tissue Engineering: A Mini-Review
Bakhtiary, N., Liu, C., & Ghorbani, F. (2021) · Gels · doi:10.3390/gels7040274 · Cited by 37
Fan, L., Cai, Z., Zhao, J., Mahmoudi, N., Wang, Y., Cheeseman, S., Aguilar, L. M. C., Reis, R. L., Kundu, S. C., Kaplan, D. L., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c18568 · Cited by 34
3D bioprinting of collagen-based materials for oral medicine
Yang, B., Liu, H., Jiang, L., Zeng, Y., Han, Y., Sha, C., Xie, X., Li, H., Zhou, J., & Lin, W. J. (2023) · Collagen and Leather · doi:10.1186/s42825-023-00129-3 · Cited by 32
Yuan, X., Xu, Y., Lu, T., He, F., Zhang, L., He, Q., & Ye, J. (2021) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2022.105104 · Cited by 30
Bioactive glass for periodontal regeneration: a systematic review
Motta, C., Cavagnetto, D., Amoroso, F., Baldi, I., & Mussano, F. D. (2023) · BMC Oral Health · doi:10.1186/s12903-023-02898-z · Cited by 27
Bakırcı, E., Guenat, O. T., Ahmad, S. S., & Gantenbein, B. (2022) · European Cells and Materials · doi:10.22203/ecm.v044a02 · Cited by 27
Ali, S. M., Patrawalla, N. Y., Kajave, N. S., Brown, A. B., & Kishore, V. (2022) · Biomacromolecules · doi:10.1021/acs.biomac.2c00985 · Cited by 26
Self-citationZheng, L., Tseomashko, N. E., Voronova, А. A., Vasil’kov, A. Y., Hu, X., & Wang, X. (2024) · Collagen and Leather · doi:10.1186/s42825-024-00164-8 · Cited by 25
Current and Future Perspectives of Bioactive Glasses as Injectable Material
Mîrț, A.-L., Ficai, D., Oprea, O., Vasilievici, G., & Ficai, A. (2024) · Nanomaterials · doi:10.3390/nano14141196 · Cited by 20
Du, J., Fan, L., Razal, J. M., Chen, S., Zhang, H., Yang, H., Li, H., & Li, J. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01256e · Cited by 22
Chen, C.-L., Wei, S., Chen, W., Hsu, T.-L., & Chen, Y. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231201231 · Cited by 21
Biological and bioactivity assessment of dextran nanocomposite hydrogel for bone regeneration
Nikpour, P., Kenari, H. S., & Rabiee, S. M. (2021) · Progress in Biomaterials · doi:10.1007/s40204-021-00171-6 · Cited by 21
Patrawalla, N. Y., Kajave, N. S., & Kishore, V. (2022) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37452 · Cited by 15
Self-citationMachour, M., Meretzki, R., Moshe-Haizler, Y., Shuhmaher, M., Safina, D., Levy, M. M., & Levenberg, S. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123406 · Cited by 14
Kajave, N. S., Schmitt, T., Patrawalla, N. Y., & Kishore, V. (2022) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2022.0035 · Cited by 13
Self-citationAn Anti-Oxidative Bioink for Cartilage Tissue Engineering Applications
Chen, X., Yang, M., Zhou, Z. Y., Sun, J., Meng, X., Huang, Y., Zhu, W., Zhu, S., He, N., Zhu, X., et al. (2024) · Journal of Functional Biomaterials · doi:10.3390/jfb15020037 · Cited by 12
Tang, Y., Zhang, Y., Zou, L., Sun, C., Tang, W., Zou, Y., Zhou, A., Fu, W., Wang, F., Li, K., et al. (2025) · Biofabrication · doi:10.1088/1758-5090/adcbd7 · Cited by 12
Rajabi, M., Cabral, J. D., Saunderson, S. C., Gould, M. L., & Ali, A. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acf90a · Cited by 12
Günyaktı, A., Altunay, B. B., Pinarbasi, B., Topuz, B. B., Huri, P. Y., & Karakeçili, A. G. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144255 · Cited by 10
Hybprinting for musculoskeletal tissue engineering
Li, J., Kim, C., Pan, C., Babian, A., Lui, E., Young, J. L., Moeinzadeh, S., Kim, S., & Yang, Y. (2022) · iScience · doi:10.1016/j.isci.2022.104229 · Cited by 9
Lourenço, L. R., Borges, R., Carastan, D. J., Mathor, M. B., & Marchi, J. (2024) · Bioprinting · doi:10.1016/j.bprint.2024.e00359 · Cited by 8
Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular Hydrogels
Qiu, J., Ma, S., & Qu, X. (2025) · Nano Select · doi:10.1002/nano.202400149 · Cited by 8
Francis, J. N., Saha, S., Tiwari, D., Chugh, A., Singh, J., & Banerjee, I. (2024) · Polymer Composites · doi:10.1002/pc.29393 · Cited by 6
Collagen Based 3D Printed Scaffolds for Tissue Engineering
Ghosh, S., Sarkar, B., Mishra, R., Thorat, N. D., & Thongmee, S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.103914 · Cited by 6
Bioglass-Reinforced Spongin-Like Collagen Scaffolds for Osteoporotic Bone Tissue Engineering
Cruz, M. D. A., Sousa, K. D. S. J., Avanzi, I. R., de Souza, A., Martignago, C. C. S., Bonifácio, M., Delpupo, F. V. B., Simões, M. C., Souza-Silva, L. C., Parisi, J. R., et al. (2025) · ACS Omega · doi:10.1021/acsomega.5c05580 · Cited by 3
Direct ink writing of bone-specific implantable scaffolds and devices
Dutta, S. D., & Lim, K. (2026) · Progress in Materials Science · doi:10.1016/j.pmatsci.2026.101796 · Cited by 3
Biocomposites hydrogel-based scaffolds in tissue engineering and regeneration
Pina, S., Reis, R. L., & Oliveira, J. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823948-3.00032-4 · Cited by 1
Bodowara, F. S., Alshaybani, A. M., & Akhremitchev, B. B. (2024) · Journal of nano research · doi:10.4028/p-id804i · Cited by 1
Antunes, B. S. L., Pedrini, F., Komatsu, D., Asami, J., Dicko, C., & Duek, E. A. R. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.154129
Cellular Requirements and Preparation for Bioprinting
Dasgupta, S., Sharma, V., & Barui, A. (2024) · Wiley eBooks · doi:10.1002/9781119894407.ch2
Research Progress of 3D Printing Technology in Anterior Cruciate Ligament Reconstruction
Peng, Q., Chen, H., He, Y., & Chen, T. (2024) · Biomedical Data Science · doi:10.47297/wspbdswsp2752-630503.20240403
Additive Manufacturing of Bioactive Glasses: Focus on Bone Tissue Engineering
Kargozar, S., Mozafari, M., Kermani, F., Milan, P. B., & Baino, F. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815313895124010005
Nahla, M. A., Abouelela, Y. S., Amer, M., Ali, M. F. B., Prince, A. M., Tolba, A., & Mostafa, A. A. (2025) · Veterinary Sciences · doi:10.3390/vetsci12080725
Maillard, M. (2022) · theses.fr (ABES) · doi:10.70675/6554ee3fz678cz440fz9db0zd3365ebeacc0
Fibrin, from blood to bone: a review
Danguir, H., Reiniche, L., Mabrouk, K. E., Ducret, M., Bricha, M., & Bekhouche, M. (2026) · Bone Reports · doi:10.1016/j.bonr.2026.101925
Chinh, N. T., Trung, V. Q., Cấn, V. M., Le, V. H., Vu, Q. T., & Thai, H. (2026) · RSC Advances · doi:10.1039/d6ra02802k
Designing Tissue Function Through Embedded Bioprinting Architectures
Li, Q., Cao, Y., Lin, J., Yang, H., & Zhou, H. (2026) · Advanced Science · doi:10.1002/advs.77342
3D-printed composite scaffolds containing silica microspheres for bone regeneration
Perpiñan-Blasco, M., Mateos‐Timoneda, M. A., & Pérez, R. A. (2026) · Materials Today Communications · doi:10.1016/j.mtcomm.2026.116117
Gelatin, collagen, and chondroitin sulfate in 3D bioprinting
Nguyen, T. C., Vu, Q. T., & Thai, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34207-3.00019-8
Self-citation
Metadata
- Authors
- Kajave, N. S., Schmitt, T., Nguyen, T.-U., Gaharwar, A. K., & Kishore, V.
- Affiliations
- Florida Institute of Technology (US)
- Texas A&M University (US)
- Corresponding author
- Kishore, Vipuil
- Venue
- Biomedical Materials
- Publisher
- IOP Publishing
- Published
- 2021-02-26
- Volume
- 16
- Issue
- 3
- Pages
- 035003
- ISSN
- 1748-6041 (ISSN-L)
- 1748-605X
- PMC
- PMC8326306
- OpenAlex
- W3096856907
- Cited by
- 46
- References
- 53
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 6
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biomedical Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Center for Scientific Review (1R15AR071102)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Building and Construction › Innovations in Concrete and Construction Materials
- Keywords
- 45S5 bioactive glass, 3D bioprinting, bone tissue engineering, collagen gel, rheological properties, mesenchymal stem cells, alkaline phosphatase activity, calcium deposition
- MeSH terms
- Bone and Bones, Ceramics, Collagen, Humans, Ink, Tissue Engineering, Tissue Scaffolds, Mesenchymal Stem Cells, Printing, Three-Dimensional
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
