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An Update on Photodynamic Therapy Applications
Abstract
Photodynamic therapy (PDT), following health agency approvals throughout the world for various cancers and other diseases, is slowly being accepted as a standard treatment to be added to the medical practitioner's armamentarium. This includes palliative treatments such as for obstructive esophageal and lung cancers as well as those intended for cure, early stage lung cancer, and actinic keratoses. A particularly new and important application is for the treatment of age-related macular degeneration (AMD), where PDT (Visudyne) has made a major impact on the outcome of this disease, the major cause of blindness in those over the age of 50. In the cancer field, while not yet approved (pending), the use of PDT in treatment of high-grade dysplasia (HGD) in Barrett's esophagus may well change how this disease is currently treated (often esophagectomy). Mechanistically, the recognition of apoptosis as an important mode of cell death following PDT and the critical role of the inflammatory process and immunity has only recently been recognized. This review updates the current and future role of PDT in cancer and other diseases.
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(2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)00967-9 · Cited by 814
Cited by
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Dye Sensitizers for Photodynamic Therapy
Ormond, A., & Freeman, H. (2013) · Materials · doi:10.3390/ma6030817 · Cited by 847
Effect of Cell-Photosensitizer Binding and Cell Density on Microbial Photoinactivation
Demidova, T. N., & Hamblin, M. R. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.6.2329-2335.2005 · Cited by 432
Symposium‐in‐Print: Singlet Oxygen Invited Review
Redmond, R. W., & Kochevar, I. E. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-04-14-ir-874 · Cited by 421
Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model
Castano, A. P., Mroz, P., Wu, M. X., & Hamblin, M. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709256105 · Cited by 201
Metadata
- Authors
- Dougherty, T. J.
- Venue
- Journal of Clinical Laser Medicine & Surgery
- Publisher
- SAGE Publications
- Published
- 2002-02
- Volume
- 20
- Issue
- 1
- Pages
- 3-7
- ISSN
- 1044-5471 (ISSN-L)
- 1557-8089
- OpenAlex
- W2039346519
- Cited by
- 546
- References
- 1
- FWCI
- 31.03
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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