CoChat
Sign Up
Cited by 123Bone Tissue Engineering MaterialsTissue Engineering and Regenerative MedicineDental Implant Techniques and Outcomes

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Tissue Engineering for Bone Regeneration Using Differentiated Alveolar Bone Cells in Collagen Scaffolds

Xiao, Y., Qian, H., Young, W.G., Bartold, P.M.·2003·Tissue Engineering
DOI 10.1089/10763270360728071
Open this paper in CoChat — free account

Abstract

Regeneration of osseous defects by a tissue-engineering approach provides a novel means of treatment utilizing cell biology, materials science, and molecular biology. In this study the concept of tissue engineering was tested with collagen type I matrices seeded with cells with osteogenic potential and implanted into sites where osseous damage had occurred. Explant cultures of cells from human alveolar bone and gingiva were established. When seeded into a three-dimensional type I collagen-based scaffold, the bone-derived cells maintained their osteoblastic phenotype as monitored by mRNA and protein levels of the bone-related proteins including bone sialoprotein, osteocalcin, osteopontin, bone morphogenetic proteins 2 and 4, and alkaline phosphatase. These in vitro-developed matrices were implanted into critical-size bone defects in skulls of immunodeficient (SCID) mice. Wound healing was monitored for up to 4 weeks. When measured by microdensitometry the bone density within defects filled with osteoblast-derived matrix was significantly higher compared with defects filled with either collagen scaffold alone or collagen scaffold impregnated with gingival fibroblasts. New bone formation was found at all the sites treated with the osteoblast-derived matrix at 28 days, whereas no obvious new bone formation was identified at the same time point in the control groups. In situ hybridization for the human-specific Alu gene sequence indicated that the newly formed bone tissue resulted from both transplanted human osteoblasts and endogenous mesenchymal stem cells. The results indicate that cells derived from human alveolar bone can be incorporated into bioengineered scaffolds and synthesize a matrix, which on implantation can induce new bone formation.

Overview

Integrity signals

Registry

Crossref · 10.1089/10763270360728071

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Bone becomes defective due to conditions such as tumor, infection (osteomyelitis), diseases (cancer, osteoporosis, osteonecrosis, rickets), trauma, biochemical disorder, and abnormal skeletal development.

    “Generally, the bone becomes defective due to the conditions such as a tumor, infection (osteomyelitis), diseases (cancer, osteoporosis, osteonecrosis, osteoporosis, rickets), trauma, biochemical disorder, abnormal skeletal development, etc [4].”

    From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [4]

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Bouvier M., 1991, Cell. Mol. Biol., 37, 509

Cited by

Sorted by citations

Related

Metadata

Authors
Xiao, Y., Qian, H., Young, W. G., & Bartold, P. M.
Affiliations
  • The University of Queensland (AU)
  • The University of Adelaide (AU)
ORCID
Venue
Tissue Engineering
Publisher
SAGE Publications
Published
2003-12
Volume
9
Issue
6
Pages
1167-1177
ISSN
  • 1076-3279 (ISSN-L)
  • 1557-8690
DOI
10.1089/10763270360728071
OpenAlex
W1559893129
Cited by
123
References
26
Citations by year
2026: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 7 · 2012: 10
FWCI
4.22
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Tissue Engineering (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • Faculty of Built Environment and Engineering
Funders
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
Keywords
bone regeneration, alveolar bone cells, osteoblasts, type I collagen scaffold, critical-size bone defect, gingival fibroblasts, osteogenic differentiation, bone morphogenetic proteins, bone sialoprotein, osteocalcin, alkaline phosphatase, mesenchymal stem cells, bone tissue engineering
MeSH terms
Alveolar Process, Bone Regeneration, Cell Differentiation, Cells, Cultured, Collagen, Membranes, Artificial, Osteoblasts, Osteogenesis, Radiography, Skull Fractures, Wound Healing, Bone Density, Porosity, Osseointegration, Cell Culture Techniques, Tissue Engineering

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review