The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
In Vivo Bone Tissue Engineering Using Mesenchymal Stem Cells on a Novel Electrospun Nanofibrous Scaffold
Abstract
The objective of this study was to assess bone formation from mesenchymal stem cells (MSCs) on a novel nanofibrous scaffold in a rat model. A highly porous, degradable poly(epsilon-caprolactone) (PCL) scaffold with an extracellular matrix-like topography was produced by electrostatic fiber spinning. MSCs derived from the bone marrow of neonatal rats were cultured, expanded, and seeded on the scaffolds. The cell-polymer constructs were cultured with osteogenic supplements in a rotating bioreactor for 4 weeks, and subsequently implanted in the omenta of rats for 4 weeks. The constructs were explanted and characterized by histology, immunohistochemistry, and scanning electron microscopy. The constructs maintained the size and shape of the original scaffolds. Morphologically, the constructs were rigid and had a bone-like appearance. Cells and extracellular matrix (ECM) formation were observed throughout the constructs. In addition, mineralization and type I collagen were also detected. This study establishes the ability to develop bone grafts on electrospun nanofibrous scaffolds in a well-vascularized site using MSCs.
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Cited by
Biodegradable polymers as biomaterials
Nair, L. S., & Laurencin, C. T. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.017 · Cited by 4,416
Industrial Upscaling of Electrospinning and Applications of Polymer Nanofibers: A Review
Persano, L., Camposeo, A., Tekmen, C., & Pisignano, D. (2013) · Macromolecular Materials and Engineering · doi:10.1002/mame.201200290 · Cited by 965
3D Printing of Scaffolds for Tissue Regeneration Applications
Do, A., Khorsand, B., Geary, S. M., & Salem, A. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500168 · Cited by 949
Ding, D.-C., Shyu, W.-C., & Lin, S.-Z. (2011) · Cell Transplantation · doi:10.3727/096368910x · Cited by 894
Electrospinning for tissue engineering scaffolds
Lannutti, J., Reneker, D., Ma, T., Tomasko, D., & Farson, D. (2007) · Materials Science and Engineering: C · doi:10.1016/j.msec.2006.05.019 · Cited by 693
Metadata
- Authors
- Shin, M., Yoshimoto, H., & Vacanti, J. P.
- Venue
- Tissue Engineering
- Publisher
- SAGE Publications
- Published
- 2004-01
- Volume
- 10
- Issue
- 1-2
- Pages
- 33-41
- ISSN
- 1076-3279 (ISSN-L)
- 1557-8690
- OpenAlex
- W1985395264
- Cited by
- 434
- References
- 1
- FWCI
- 15.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shin, M., Yoshimoto, H., & Vacanti, J. P. (2004). In Vivo Bone Tissue Engineering Using Mesenchymal Stem Cells on a Novel Electrospun Nanofibrous Scaffold. Tissue Engineering. https://doi.org/10.1089/107632704322791673
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
