The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The Evolution of Pandemic Clones of Methicillin-Resistant Staphylococcus aureus : Identification of Two Ancestral Genetic Backgrounds and the Associated mec Elements
Abstract
Previous surveillance studies carried out by our laboratories, primarily in Southern and Eastern Europe, Latin America, and the United States, have characterized 3,067 methicillin-resistant Staphylococcus aureus (MRSA) hospital isolates by a combination of molecular typing methods. Nearly 70% of these isolates could be classified into five clonal types showing extensive geographic spread. Representative isolates of these clonal types were now reexamined for their genetic relatedness by multilocus sequence typing (MLST) and by sequencing the polymorphic region of protein A ( spaA typing), and also for the type of the Staphylococcal Chromosomal Cassette (SCC mec ) resident in the bacteria. Three of the previously classified clonal types (Iberian, Brazilian, and Hungarian clones) shared a common or closely related genetic background A, which was the same as the background of the earliest European isolates of MRSA from England and Denmark. The Pediatric and New York/Japan clones belonged to a completely different genetic background B. The three recently described SCC mec types were specifically associated with different pandemic clones: types I and III with isolates of genetic background A and type II with isolates of genetic background B. A novel SCC mec related to type I, called SCC mec type IV, was identified in some MRSA strains belonging to genetic background A as well as B. Structural variations in SCC mec types I and III were also observed. The data allow tentative identification of an evolutionary pathway for the emergence of pandemic MRSA clones and also provide evidence for the multiple, yet restricted, numbers of acquisition of the mec element by S. aureus .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Fourteen major types of SCCmec have been described and sequenced, and within the major types are several subtypes [26,27,28,29,30,31,32].”
From Molecular Mechanisms of Drug Resistance in Staphylococcus aureus (2022) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
A Link Between Virulence and Ecological Abundance in Natural Populations of Staphylococcus aureus
Day, N., Moore, C. E., Enright, M. C., Berendt, A. R., Smith, J. M., Murphy, M. F., Peacock, S. J., Spratt, B. G., & Feil, E. J. (2001) · Science · doi:10.1126/science.1056495 · Cited by 108
RetractedMaiden, M. C. J., Bygraves, J. A., Feil, E., Morelli, G., Russell, J. E., Urwin, R., Zhang, Q., Zhou, J., Zurth, K., Caugant, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3140 · Cited by 3,833
Enright, M. C., Day, N. P. J., Davies, C. E., Peacock, S. J., & Spratt, B. G. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.3.1008-1015.2000 · Cited by 3,063
Whole genome sequencing of meticillin-resistant Staphylococcus aureus
Kuroda, M., Ohta, T., Uchiyama, I., Baba, T., Yuzawa, H., Kobayashi, I., Cui, L., Oguchi, A., Aoki, K.-I., Nagai, Y., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04403-2 · Cited by 1,961
The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
Enright, M. C., Robinson, D. A., Randle, G., Feil, E. J., Grundmann, H., & Spratt, B. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122108599 · Cited by 1,588
Enright, M. C., & Spratt, B. G. (1998) · Microbiology · doi:10.1099/00221287-144-11-3049 · Cited by 1,074
Katayama, Y., Ito, T., & Hiramatsu, K. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.6.1549-1555.2000 · Cited by 1,038
Shopsin, B., Gomez, M., Montgomery, S. O., Smith, D. H., Waddington, M., Dodge, D. E., Bost, D. A., Riehman, M., Naidich, S., & Kreiswirth, B. N. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.11.3556-3563.1999 · Cited by 984
Ito, T., Katayama, Y., Asada, K., Mori, N., Tsutsumimoto, K., Tiensasitorn, C., & Hiramatsu, K. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.5.1323-1336.2001 · Cited by 963
Ito, T., Katayama, Y., & Hiramatsu, K. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.6.1449 · Cited by 450
Cited by
Waves of resistance: Staphylococcus aureus in the antibiotic era
Chambers, H. F., & DeLeo, F. R. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2200 · Cited by 2,718
Vandenesch, F., Naimi, T., Enright, M. C., Lina, G., Nimmo, G. R., Heffernan, H., Liassine, N., Bes, M., Greenland, T., Reverdy, M.-E., et al. (2003) · Emerging Infectious Diseases · doi:10.3201/eid0908.030089 · Cited by 1,727
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,637
Antimicrobial resistance: the example of Staphylococcus aureus
Lowy, F. D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18535 · Cited by 1,445
Zhang, K., McClure, J.-A., Elsayed, S., Louie, T., & Conly, J. M. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.10.5026-5033.2005 · Cited by 1,037
Metadata
- Authors
- Oliveira, D. C., Tomasz, A., & de Lencastre, H.
- Venue
- Microbial Drug Resistance
- Publisher
- SAGE Publications
- Published
- 2001-12
- Volume
- 7
- Issue
- 4
- Pages
- 349-361
- ISSN
- 1076-6294 (ISSN-L)
- 1931-8448
- OpenAlex
- W2134366416
- Cited by
- 301
- References
- 42
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Evolution of Pandemic Clones of Methicillin-Resistant Staphylococcus aureus : Identification of Two Ancestral Genetic Backgrounds and the Associated mec Elements. https://app.cochat.ai/papers/10.1089/10766290152773365
- The paper
- Oliveira, D. C., Tomasz, A., & de Lencastre, H. (2001). The Evolution of Pandemic Clones of Methicillin-Resistant Staphylococcus aureus : Identification of Two Ancestral Genetic Backgrounds and the Associated mec Elements. Microbial Drug Resistance. https://doi.org/10.1089/10766290152773365
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
