The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Review: On the Role of IRF in Host Defense
Abstract
Transcription factors of the interferon (IFN) regulatory factor (IRF) family have been shown to play an essential role in the regulated expression of type I IFN genes, IFN-stimulated genes (ISG), and other cytokines and chemokines. Three members of the IRF family, IRF-3, IRF-5, and IRF-7, have been identified as acting as direct transducers of virus-mediated signaling. In infected cells, these factors are activated by phosphorylation on the serine residues, transported to the nucleus, where they bind to the promoters of IFNA and IFNB genes and tether histone transacetylases to the transcription complex enhanceosome. IFNB and IFNA subtypes are expressed at different levels in infected cells. The ratio between the relative levels of IRF-3 and IRF-7 was shown to play an essential role in the inducible expression of type I IFN genes, whereas IRF-3 alone is sufficient for expression of the IFNB gene. IRF-5 was identified recently as another inducer of IFNA genes, which has two unique properties: (1) its activation is virus specific, and (2) the profile of IFNA genes induced by IRF-5 is distinct from that induced by IRF-7. Several viruses target functions of IRF to eliminate the early inflammatory response. Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of four genes with homology to cellular IRF. Three of these vIRF were shown to inhibit induction of IFN genes and ISG in infected cells and function as dominant negative mutants of cellular IRF. The unique properties of previously uncharacterized vIRF-2 and vIRF-3 are discussed.
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1 retracted
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Cited by
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IKKε and TBK1 are essential components of the IRF3 signaling pathway
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Viruses and interferon: a fight for supremacy
Katze, M. G., He, Y., & Gale, M. (2002) · Nature Reviews Immunology · doi:10.1038/nri888 · Cited by 1,419
Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease
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The airway epithelium: soldier in the fight against respiratory viruses
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Metadata
- Authors
- Barnes, B., Lubyova, B., & Pitha, P. M.
- Venue
- Journal of Interferon & Cytokine Research
- Publisher
- SAGE Publications
- Published
- 2002-01
- Volume
- 22
- Issue
- 1
- Pages
- 59-71
- ISSN
- 1079-9907 (ISSN-L)
- 1557-7465
- OpenAlex
- W99207100
- Cited by
- 318
- References
- 96
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- closed
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