The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease
Open accessAbstract
Persistent infections with hepatitis C virus (HCV) are likely to depend on viral inhibition of host defenses. We show that the HCV NS3/4A serine protease blocks the phosphorylation and effector action of interferon regulatory factor–3 (IRF-3), a key cellular antiviral signaling molecule. Disruption of NS3/4A protease function by mutation or a ketoamide peptidomimetic inhibitor relieved this blockade and restored IRF-3 phosphorylation after cellular challenge with an unrelated virus. Furthermore, dominant-negative or constitutively active IRF-3 mutants, respectively, enhanced or suppressed HCV RNA replication in hepatoma cells. Thus, the NS3/4A protease represents a dual therapeutic target, the inhibition of which may both block viral replication and restore IRF-3 control of HCV infection.
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Cites
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Self-citationEfficient Initiation of HCV RNA Replication in Cell Culture
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Cited by
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401
Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
Loo, Y.-M., Fornek, J., Crochet, N., Bajwa, G., Perwitasari, O., Martinez-Sobrido, L., Akira, S., Gill, M. A., García-Sastre, A., Katze, M. G., et al. (2008) · Journal of Virology · doi:10.1128/jvi.01080-07 · Cited by 1,071
Self-citationMechanism of action of interferon and ribavirin in treatment of hepatitis C
Feld, J. J., & Hoofnagle, J. H. (2005) · Nature · doi:10.1038/nature04082 · Cited by 992
Antiviral innate immunity pathways
Seth, R. B., Sun, L., & Chen, Z. J. (2006) · Cell Research · doi:10.1038/sj.cr.7310019 · Cited by 494
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Metadata
- Authors
- Foy, E., Li, K., Wang, C., Sumpter, R., Ikeda, M., Lemon, S. M., & Gale, M.
- Venue
- Science
- Published
- 2003-05-16
- Volume
- 300
- Issue
- 5622
- Pages
- 1145-1148
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046714103
- Cited by
- 788
- References
- 23
- FWCI
- 25.48
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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