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Cited by 123Renal Diseases and GlomerulopathiesLipoproteins and Cardiovascular HealthNatural Products and Biological Research

The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.

Hypocholesterolemic Effect of Spirulina in Patients with Hyperlipidemic Nephrotic Syndrome

Samuels, R., Mani, U.V., Iyer, U.M., Nayak, U.S.·2002·Journal of Medicinal Food
DOI 10.1089/109662002760178177
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Abstract

In nephrotic syndrome, large amounts of plasma proteins are lost in urine, causing a decrease in the plasma oncotic pressure. This leads to enhanced hepatic synthesis of albumin and other proteins, including lipoproteins, causing a secondary hyperlipidemia. Essential fatty acids such as gamma-linolenic acid (GLA) can prevent accumulation of cholesterol in the body, and spirulina has an appreciable amount of GLA. In this study 23 patients (age 2 to 13 years) with nephrotic syndrome received either medication (group I) or medication plus 1 g/day Spirulina (group II). Height, weight, and serum levels of fasting blood sugar, triglycerides, total cholesterol (TC), and low- and high-density cholesterol fractions (LDL-C and HDL-C, respectively) were measured before and after the 2-month study period. Mean height and weight were normal compared with healthy, age-matched Indian children. Lipoprotein cholesterol levels were significantly increased at baseline. TC significantly decreased by 116.33 mg/dl, LDL-C by 94.14 mg/dl, and triglycerides by 67.72 mg/dl in group II; in control group I, these values fell by 69.87, 61.13, and 22.62 mg/dl, respectively. The LDL-C:HDL-C ratio also decreased significantly, by 1.66 in group II and 1.13 in group I. TC:HDL-C decreased by 1.96 in group II and 1.19 in group I. HDL-C:LDL-C also improved significantly in both the groups. It can be concluded that spray-dried Spirulina capsules, rich in antioxidants, GLA, amino acids, and fatty acids, helped reduce the increased levels of lipids in patients with hyperlipidemic nephrotic syndrome.

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Crossref · 10.1089/109662002760178177

Cites

20 of 20 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 21 references

Research works printed but not linked: 11

  1. Attman PO, 1999, Kidney Int, 71, S7
  2. Mani I, 1988, Arogya J Health Sci, 24, 77
  3. Tohoku J, 1997, J Exp Med, 181, 321
  4. Fuiano G, 1996, Nephron, 73, 439
  5. Keane WF, St, 1992, Kidney Int, 42, S134
  6. Hutchison FN, 1993, Miner Electrolyte Metab, 19, 127
  7. Nayaka N, 1988, Nutrition Report International, 37, 1329
  8. Devi MA, 1983, Nutr Rep Int, 28, 519
  9. Ramamoorthy A, 1996, J Food Sci Technol, 33, 124
  10. Nayak SS, 1988, Indian J Med Res, 88, 150
  11. Khanna UB, 1985, J Postgrad Med, 31, 140

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Metadata

Authors
Samuels, R., Mani, U. V., Iyer, U. M., & Nayak, U. S.
Affiliations
Maharaja Sayajirao University of Baroda (IN)
Venue
Journal of Medicinal Food
Publisher
SAGE Publications
Published
2002-06
Volume
5
Issue
2
Pages
91-96
ISSN
  • 1096-620X (ISSN-L)
  • 1557-7600
DOI
10.1089/109662002760178177
OpenAlex
W1599538912
Cited by
123
References
21
Citations by year
2025: 5 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 13 · 2014: 7 · 2013: 5 · 2012: 9
FWCI
0.68
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Journal of Medicinal Food (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
Keywords
Spirulina, nephrotic syndrome, hyperlipidemia, secondary hyperlipidemia, gamma-linolenic acid, cholesterol lowering, LDL cholesterol, HDL cholesterol, triglycerides, children, dietary supplementation, lipoproteins
MeSH terms
Adolescent, Anticholesteremic Agents, Bacterial Proteins, Body Height, Body Weight, Child, Child, Preschool, Cholesterol, Female, Humans, Hyperlipidemias, Cholesterol, HDL, Cholesterol, LDL, Male, Nephrotic Syndrome, Triglycerides, gamma-Linolenic Acid, Spirulina

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