Cited by 269Heavy Metal Exposure and ToxicityTrace Elements in HealthMetal complexes synthesis and properties

Zinc Finger Proteins as Potential Targets for Toxic Metal Ions: Differential Effects on Structure and Function

Hartwig, Andrea·2001·Antioxidants & Redox Signaling

Abstract

Zinc finger structures are frequently found in transcription factors and DNA repair proteins, mediating DNA-protein and protein-protein binding. As low concentrations of transition metal compounds, including those of cadmium, nickel, and cobalt, have been shown to interfere with DNA transcription and repair, several studies have been conducted to elucidate potential interactions of toxic metal ions with zinc-binding protein domains. Various effects have been identified, including the displacement of zinc, e.g., by cadmium or cobalt, the formation of mixed complexes, incomplete coordination of toxic metal ions, as well as the oxidation of cysteine residues within the metal-binding domain. Besides the number of cysteine and/or histidine ligands, unique structural features of the respective protein under investigation determine whether or not zinc finger structures are disrupted by one or more transition metals. As improper folding of zinc finger domains is mostly associated with the loss of correct protein function, disruption of zinc finger structures may result in interference with manifold cellular processes involved in gene expression, growth regulation, and maintenance of the genomic integrity.

Integrity signals

Registry

Crossref · 10.1089/15230860152542970

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

1 retracted

Flagged first, then by citations

1 of the 63 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Hartwig, A.
Affiliations
Karlsruhe Institute of Technology (DE)
Corresponding author
Hartwig, Andrea
Venue
Antioxidants & Redox Signaling
Published
2001-08
Volume
3
Issue
4
Pages
625-634
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
OpenAlex
W1983045184
Cited by
269
References
63
Citations by year
2026: 8 · 2025: 3 · 2024: 5 · 2023: 12 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 8 · 2016: 13 · 2015: 15 · 2014: 15 · 2013: 12 · 2012: 14
FWCI
7.38
Type
journal article
Language
en
Open access
closed
Locations
  • Antioxidants and Redox Signaling (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
Keywords
zinc finger proteins, toxic metal ions, cadmium, nickel, cobalt, metal ion binding, zinc displacement, heterometallic complexes, cysteine oxidation, histidine ligands, protein misfolding, transcription factors, DNA repair proteins
MeSH terms
Binding, Competitive, DNA, DNA Repair, Humans, Metals, Neoplasm Proteins, Protein Binding, Protein Conformation, Structure-Activity Relationship, Transcription Factors, Transcription, Genetic, Xeroderma Pigmentosum, Zinc Fingers, Protein Folding, Denys-Drash Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review