Can micronutrients improve neurocognitive functioning in adults with ADHD and severe mood dysregulation? A pilot study
Abstract
OBJECTIVES: Little research has investigated how micronutrients (minerals and vitamins) affect cognitive functioning, despite preliminary studies showing they may improve psychiatric functioning. INTERVENTION: This pilot study investigated the impact of a 36-ingredient micronutrient formula consisting mainly of vitamins and minerals on neurocognitive functioning in 14 adults with attention-deficit/hyperactivity disorder (ADHD) and severe mood dysregulation. DESIGN: The formula was consumed in an open-label trial over an 8-week period. OUTCOME MEASURES: The participants completed tests of memory (Wide Range Assessment of Memory and Learning) and executive functioning (Delis-Kaplan Executive Functioning System and Conners Continuous Performance Test) at baseline and at the end of the trial. A gender- and age-matched control group of 14 non-ADHD adults not taking the formula were assessed on the same tests 8 weeks apart in order to investigate the impact of practice on the results. RESULTS: There were no group differences in ethnicity, socio-economic status and estimated IQ. Significant improvement was observed in the ADHD group, but not the control group, across a range of verbal abilities including verbal learning, verbal cognitive flexibility and fluency, and verbal inhibition. These neurocognitive improvements were large and consistent with improved psychiatric functioning. No changes were noted above a practice effect in visual-spatial memory and there were no improvements noted in reaction time, working memory, or rapid naming for either groups. CONCLUSIONS: Although the pilot and open-label design of the study limits the generalizability of the results, it supports a growing body of literature recognizing the importance of nutrients for mental health and cognition. The results also provide evidence supporting the need for randomized clinical trials of micronutrients as well as other experimental studies in order to better assess whether improved neurocognitive functioning may contribute to improved psychiatric symptoms.
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A significant increase in hemoglobin levels was observed when taking 1-2 g per day for six to seven weeks.
“A significant increase in hemoglobin levels was observed when taking 1–2 g per day for six to seven weeks [119].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [119]
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- Authors
- Rucklidge, J. J., Harrison, R., & Johnstone, J.
- Affiliations
- University of Canterbury (NZ)
- Venue
- The Journal of Alternative and Complementary Medicine
- Publisher
- SAGE Publications
- Published
- 2011-12
- Volume
- 17
- Issue
- 12
- Pages
- 1125-1131
- ISSN
- 1075-5535 (ISSN-L)
- 1557-7708
- OpenAlex
- W2013854474
- Cited by
- 16
- References
- 33
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 3 · 2020: 1 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Alternative and Complementary Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- micronutrients, vitamins and minerals, attention deficit hyperactivity disorder, mood dysregulation, neurocognitive function, memory, executive function, cognitive flexibility, verbal inhibition, dietary supplementation, adults
- MeSH terms
- Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Female, Humans, Inhibition, Psychological, Learning Disabilities, Male, Mental Processes, Middle Aged, Minerals, Pilot Projects, Severity of Illness Index, Verbal Learning, Vitamins, Case-Control Studies, Mood Disorders, Young Adult, Executive Function
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