Influence of a Specific Ginger Combination on Gastropathy Conditions in Patients with Osteoarthritis of the Knee or Hip
Abstract
Background Nonsteroid anti-inflammatory drugs represent an important osteoarthritis (OA) therapy component, but also a leading cause of gastropathy: one of the most frequent and serious OA therapy complications. The aim of the present study was to study the influence of GI health in an OA population receiving either ginger or diclofenac. Methods Forty-three (43) patients with confirmed OA (knee and hip) were included in a randomized controlled study. A ginger group of 21 patients (17 women, 4 men) was given a specific ginger combination daily (340 mg EV.EXT 35 Zingiber officinalis extract) for 4 weeks. A diclofenac group (positive control) of 22 patients (18 women, 4 men) received 100 mg diclofenac daily for the same period. Both groups also received 1000 mg glucosamine daily. Gastrointestinal pain and dyspepsia were evaluated according to the severity of dyspepsia assessment (SODA) form. Patients also underwent esophagogastroduodenoscopy (EGDS) including biopsy before and after the treatment. Serum gastrin-17 levels, and stomach mucosa prostaglandins (PG) E1, E2, F2α, and 6-keto PGF1α (PGI2) levels were measured. Arthritic pain was evaluated using the visual analogue scale (VAS) on standing and moving. Results The ginger group showed a slight but significantly lowered SODA pain and no change of SODA dyspepsia. EGDS showed significantly increased levels of PGE1, PGE2, and PGF2α in the stomach mucosa. This rise in gastric mucosa PG levels correlated with an increase in serum g…
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Gastrin release seems to be impaired in patients with chronic constipation.
“ginger has been reported to enhance circulating levels of gastrin, which its release seems to be impaired in patients with chronic constipation [37, 38].”
Ginger has been reported to enhance circulating levels of gastrin.
“ginger has been reported to enhance circulating levels of gastrin, which its release seems to be impaired in patients with chronic constipation [37, 38].”
Several trials reported positive effects of ginger on at least one dyspepsia symptom, such as nausea, bloating, and abdominal pain.
“several trials reported positive effects of ginger on at least one dyspepsia symptom, such as nausea, bloating, and abdominal pain [14, 37, 41, 42].”
Long-term studies (i.e., 2-4 weeks) found significant beneficial effects of ginger on dyspepsia symptoms.
“Long-term studies (i.e., 2–4 weeks) found significant beneficial effects of ginger on dyspepsia symptoms [14, 37, 41, 42]”
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- Authors
- Drozdov, V. N., Kim, V. A., Tkachenko, E. V., & Varvanina, G. G.
- Affiliations
- Health Care Department, The Central Gastroenterology Scientific Research Institute, Moscow, Russia.
- Venue
- The Journal of Alternative and Complementary Medicine
- Publisher
- SAGE Publications
- Published
- 2012-06
- Volume
- 18
- Issue
- 6
- Pages
- 583-588
- ISSN
- 1075-5535 (ISSN-L)
- 1557-7708
- OpenAlex
- W1997619918
- Cited by
- 55
- References
- 16
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 1
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Alternative and Complementary Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- ginger, osteoarthritis, knee osteoarthritis, hip osteoarthritis, diclofenac, nonsteroidal anti-inflammatory drugs, gastropathy, dyspepsia, gastrin-17, glucosamine, gastrointestinal safety, mucosal protection
- MeSH terms
- Alprostadil, Anti-Inflammatory Agents, Non-Steroidal, Diclofenac, Dyspepsia, Female, Gastric Mucosa, Gastrins, Hip, Hip Joint, Humans, Knee, Knee Joint, Male, Phytotherapy, Middle Aged, Pain Measurement, Plant Extracts, Severity of Illness Index, Osteoarthritis, Hip, Dinoprostone, Dinoprost, Abdominal Pain, Endoscopy, Digestive System, Osteoarthritis, Knee, Zingiber officinale
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