Efficacy and safety of auricular therapy for depression
Abstract
Background: Researchers have found applications for auricular therapy (AT) for treating depression. There is, however, a lack of comprehensive evaluation of AT's effects and safety. Objective: The objective of this review was to evaluate the safety and efficacy of AT for treating depression. Methods: Ten databases were used to search for randomized controlled and quasi-randomized controlled trials relating to AT and depression. Related available articles up to January 2016 were used for the research. Rev Man 5.2 software was used for data analysis with the effect estimate presented as relative risk and mean difference with a 95% confidence interval. Results: Interventions of trials included in this study were either ear buried seeds (EBS) or transcutaneous vagus nerve stimulation (tVNS). Compared to sham, tVNS produced significant differences on the Hamilton Depression (HAM-D) rating scale, Beck's Depression Inventory (BDI), Self-Rate Depression Scale (SDS), and Self-Rate Anxiety Scale (SAS), but no significant difference were seen on the Hamilton Anxiety (HAM-A) scale. Compared to other treatment, tVNS produced significant differences on the HAM-D, Clinical Global Impression Scale (CGI-S) and Clinical Global Impression—Improvement (CGI-I). tVNS also had an advantage with respect to reducing side-effects. When EBS combined with other treatments was compared to other treatments, there were also significant differences on the HAM-D, SDS, SAS, remission, and Patient Assessment of Constipation Quality of Life (PAC-QOL) questionnaire, but there was no significant difference seen on the Nerve Function Defect Score Scale Barthel Index (BI). Conclusions: tVNS and EBS forms of AT could alleviate depression symptoms measured by the HAM-D. It is suggested that the designs of AT trials should follow the recommendations of the Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) guidelines. AT clinicians should use the HAM-D to gauge depression, and somatic symptom reduction should be observed separately.
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Another review conducted a systematic review to assess auricular therapy, including ear buried seeds and transcutaneous vagus nerve stimulation, for treating major depressive disorder.
“Another review conducted a systematic review to assess auricular therapy, including ear buried seeds and transcutaneous vagus nerve stimulation, for treating major depressive disorder.[28]”
From Transcutaneous auricular vagus nerve stimulation in treating major depressive disorder: A systematic review and meta-analysis (2018) · cites this paper as [28]
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Transcutaneous Vagus Nerve Stimulation Modulates Default Mode Network in Major Depressive Disorder
Fang, J., Rong, P., Yang, H., Fan, Y., Liu, J. H., Wang, H., Zhang, G., Chen, X., Shi, S. R., Wang, L., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.025 · Cited by 416 · see citing works
Self-citationKraus, T., Hösl, K. M., Kiess, O., Schanze, A., Kornhuber, J., & Forster, C. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0755-z · Cited by 410 · see citing works
Hein, E., Nowak, M., Kiess, O., Biermann, T., Bayerlein, K., Kornhuber, J., & Kraus, T. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-012-0908-6 · Cited by 282 · see citing works
Hou, P., Hsu, H., Lin, Y., et al. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/495684 · Cited by 279 · see citing works
Bauer, S., Baier, H., Baumgärtner, C., Bohlmann, K., Fauser, S., Graf, W. D., Hillenbrand, B., Hirsch, M., Last, C., Lerche, H., et al. (2016) · Brain stimulation · doi:10.1016/j.brs.2015.11.003 · Cited by 273 · see citing works
Ear Acupuncture in European Traditional Medicine
Gori, L., & Firenzuoli, F. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nem106 · Cited by 171 · see citing works
Adverse Events of Auricular Therapy: A Systematic Review
Tan, J.-Y. B., Molassiotis, A., Wang, T., et al. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/506758 · Cited by 137 · see citing works
Comorbid anxiety and depression: illumination of a controversy
Hranov, L. (2007) · International journal of psychiatry in clinical practice · doi:10.1080/13651500601127180 · Cited by 81 · see citing works
Shim, H. J., Kwak, M. Y., An, Y., Kim, D. H., Kim, Y. J., & Kim, H. J. (2015) · Journal of Audiology & Otology · doi:10.7874/jao.2015.19.3.159 · Cited by 78 · see citing works
Vagal Nerve Stimulation Therapy: What Is Being Stimulated?
Kember, G., Ardell, J. L., Armour, J. A., & Zamir, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114498 · Cited by 31 · see citing works
Pilurzi, G., Mercante, B., Ginatempo, F., Follesa, P., Tolu, E., & Deriu, F. (2015) · Experimental Brain Research · doi:10.1007/s00221-015-4477-4 · Cited by 24 · see citing works
Wang, S., Maranets, I., Lin, E. C., et al. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2011.0356 · Cited by 12 · see citing works
Treating Depression in Primary Care
Manning, J. S., & Jackson, W. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13013tx8c · Cited by 10 · see citing works
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Wu, C., Liu, P., Fu, H., Chen, W., Cui, S., Lu, L., & Tang, C. (2018) · Medicine · doi:10.1097/md.0000000000013845 · Cited by 91 · see citing works
- Authors
- Zhang, Z.-X., Li, C.-R., Rong, P.-J., Bai, Z.-H., Hill, A. M., Jing, Q., Ren, L., & Wang, C.-Y.
- Affiliations
- Liaoning University of Traditional Chinese Medicine, Huanggu District, Shenyang, China.
- Liaoning University of Traditional Chinese Medicine (CN)
- Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
- Dalian Medical University (CN)
- Corresponding author
- Wang, Chun-Yan
- ORCID
- Venue
- Medical Acupuncture
- Publisher
- SAGE Publications
- Published
- 2016-10
- Volume
- 28
- Issue
- 5
- Pages
- 256-267
- ISSN
- 1933-6586 (ISSN-L)
- 1933-6594
- OpenAlex
- W2557378487
- Cited by
- 6
- References
- 16
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2018: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Acupuncture (publishedVersion)
- Funders
- World Health Organization
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
- Social Sciences › Psychology › Social Psychology › Music Therapy and Health
- Keywords
- auricular acupuncture, depression, transcutaneous vagus nerve stimulation, treatment efficacy, treatment safety, anxiety, adverse effects, Hamilton Depression Rating Scale, remission
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