Human Endogenous Retroviral Element K10 (HERV-K10) Encodes a Full-Length Gag Homologous 73-kDa Protein and a Functional Protease

Mueller-Lantzsch, Nikolaus; Sauter, Marlies; Weiskircher, Anette; Kramer, Klaus; Best, Barbara; Buck, Marion; Grässer, Friedrich

doi:10.1089/aid.1993.9.343

Cited by 98Chromosomal and Genetic VariationsHIV Research and TreatmentT-cell and Retrovirus Studies

Human Endogenous Retroviral Element K10 (HERV-K10) Encodes a Full-Length Gag Homologous 73-kDa Protein and a Functional Protease

Mueller-Lantzsch, Nikolaus, Sauter, Marlies, Weiskircher, Anette, Kramer, Klaus, Best, Barbara, Buck, Marion, Grässer, Friedrich·1993·AIDS Research and Human Retroviruses

DOI 10.1089/aid.1993.9.343

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Abstract

The gag -homologous region of the human endogenous retrovirus K10 (HERV-K10) was amplified by PCR from human genomic DNA and was analyzed by DNA cloning, sequencing, and expression of open reading frames in the prokaryotic pATH expression system. The analysis of genomic DNA of three donors provided evidence that HERV-K10 genes contain an open reading frame of 1966 bp spanning the entire gag -homologous region. In the prokaryotic system the entire reading frame of the HERV-K10 gag gene could be expressed as a fusion protein exhibiting a molecular weight of about 110,000. In addition, when the gag -homologous region and the adjacent HERV-K10 protease gene were prokaryotically expressed, we observed a Gag-protease fusion protein that exhibited specific autoproteolytic activities and processing of HERV-K10 Gag protein. By introducing deletions on the right end of the putative protease gene an autocatalytic site could be localized within 300 bp of the putative HERV-K10 protease gene. For the first time, these results provide evidence that the HERV-K10 encodes a full-length Gag protein and a functional protease.

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From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [71]

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Human Endogenous Retrovirus K10 Encodes a Functional Integrase
Yoshiike, K. (1995)

Authors: Mueller-Lantzsch, N., Sauter, M., Weiskircher, A., Kramer, K., Best, B., Buck, M., & Grässer, F.
ORCID: Grässer, Friedrich
Venue: AIDS Research and Human Retroviruses
Publisher: SAGE Publications
Published: 1993-04
Volume: 9
Issue: 4
Pages: 343-350
ISSN: 0889-2229 (ISSN-L)
1931-8405
DOI: 10.1089/aid.1993.9.343
OpenAlex: W2011460120
Cited by: 98
References: 28
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2019: 6 · 2018: 2 · 2014: 1 · 2013: 3 · 2012: 3
FWCI: 10.75
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: AIDS Research and Human Retroviruses (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords: human endogenous retroviruses, Gag protein, proteolytic enzymes, retroviral gene expression
MeSH terms: Base Sequence, Cloning, Molecular, DNA, Viral, Escherichia coli, Humans, Molecular Sequence Data, Endopeptidases, Retroviridae, Tumor Cells, Cultured, Blotting, Southern, Immunoblotting, Gene Products, gag, Polymerase Chain Reaction, Sequence Homology

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Human Endogenous Retroviral Element K10 (HERV-K10) Encodes a Full-Length Gag Homologous 73-kDa Protein and a Functional Protease

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