Cited by 1,726Redox biology and oxidative stressAntioxidant Activity and Oxidative StressSulfur Compounds in Biology

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Redefining Oxidative Stress

Jones, Dean P.·2006·Antioxidants & Redox Signaling

DOI 10.1089/ars.2006.8.1865

Open this paper in CoChat — free account

Abstract

Oxidative stress is often defined as an imbalance of pro-oxidants and antioxidants, which can be quantified in humans as the redox state of plasma GSH/GSSG. Plasma GSH redox in humans becomes oxidized with age, in response to oxidative stress (chemotherapy, smoking), and in common diseases (type 2 diabetes, cardiovascular disease). However, data also show that redox of plasma GSH/GSSG is not equilibrated with the larger plasma cysteine/cystine (Cys/CySS) pool, indicating that the "balance" of pro-oxidants and antioxidants cannot be defined by a single entity. The major cellular thiol/disulfide systems, including GSH/GSSG, thioredoxin- 1 (-SH(2)/-SS-), and Cys/CySS, are not in redox equilibrium and respond differently to chemical toxicants and physiologic stimuli. Individual signaling and control events occur through discrete redox pathways rather than through mechanisms that are directly responsive to a global thiol/disulfide balance such as that conceptualized in the common definition of oxidative stress. Thus, from a mechanistic standpoint, oxidative stress may be better defined as a disruption of redox signaling and control. Adoption of such a definition could redirect research to identify key perturbations of redox signaling and control and lead to new treatments for oxidative stress-related disease processes.

Integrity signals

Registry

Crossref · 10.1089/ars.2006.8.1865

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

[49] Determination of carbonyl content in oxidatively modified proteins
Levine, R. L., Garland, D. L., Oliver, C. N., Amici, A., Climent, I., Lenz, A.-G., Ahn, B. W., Shaltiel, S., & Stadtman, E. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86141-h · Cited by 5,895
A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8
(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1417 · Cited by 3,285
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,651
Oxidative Stress and Vascular Disease
Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000150649.39934.13 · Cited by 1,618 · cited 1×
“titative measures of disease outcome (11, 14, 19, 41, 42, 49 55, 62, 67).”
Risk Factors for Lung Cancer and for Intervention Effects in CARET, the Beta-Carotene and Retinol Efficacy Trial
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.21.1550 · Cited by 1,255
Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer: A Randomized Controlled Trial
(2005) · JAMA · doi:10.1001/jama.293.11.1338 · Cited by 1,209 · cited 1×
“titative measures of disease outcome (11, 14, 19, 41, 42, 49 55, 62, 67).”
Oxidative Stress: Introductory Remarks
Sies, H. (1985) · Elsevier eBooks · doi:10.1016/b978-0-12-642760-8.50005-3 · Cited by 1,037
[11] Redox potential of GSH/GSSG couple: Assay and biological significance
Jones, D. P. (2002) · Methods in Enzymology · doi:10.1016/s0076-6879(02)48630-2 · Cited by 812
Self-citation
Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity
Fong, K.-L., McCay, P. B., Poyer, J. L., Keele, B. B., & Misra, H. P. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43258-4 · Cited by 650
Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus
Hirota, K., Murata, M., Sachi, Y., Nakamura, H., Takeuchi, J. S., Mori, K., & Yodoi, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27891 · Cited by 615

Show all 66 references

Research works printed but not linked: 2

Jiang S, 2002, Invest Ophthalmol Vis Sci, 43, 2546
Nelson KC, 2002, Invest Ophthalmol Vis Sci, 43, 3550

Sorted by citations

Items 501–600 of 1,000

Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging
Hamilton, R. T. (2012) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.s4-005 · Cited by 53
Comparative sensitivity of the hepatopancreas and midgut in the white shrimp Litopenaeus vannamei to oxidative stress under cyclic serious/medium hypoxia
Han, S.-Y., Wang, M., Liu, M., Wang, B., Jiang, K., & Wang, L. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.02.021 · Cited by 53
Influence of Long-Term Fasting on Blood Redox Status in Humans
de Toledo, F. W., Grundler, F., Goutzourelas, N., Tekos, F., Vassi, E., Mesnage, R., & Kouretas, D. (2020) · Antioxidants · doi:10.3390/antiox9060496 · Cited by 55
The Keap1/Nrf2 Signaling Pathway in the Thyroid—2020 Update
Thanas, C., Ziros, P. G., Chartoumpekis, D. V., Renaud, C. O., & Sykiotis, G. P. (2020) · Antioxidants · doi:10.3390/antiox9111082 · Cited by 55
Links between thrombosis and inflammation in traumatic brain injury
Hubbard, W. B., Dong, J., Crúz, M. A., & Rumbaut, R. E. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.10.041 · Cited by 57
Oxidative Stress and Its Role in Cd-Induced Epigenetic Modifications: Use of Antioxidants as a Possible Preventive Strategy
Cruz, E. Y. H., Arancibia‐Hernández, Y. L., Loyola-Mondragón, D. Y., & Pedraza‐Chaverrí, J. (2022) · Oxygen · doi:10.3390/oxygen2020015 · Cited by 59
Mitochondrial hydrogen peroxide production by pyruvate dehydrogenase and α-ketoglutarate dehydrogenase in oxidative eustress and oxidative distress
Chalifoux, O., Faerman, B., & Mailloux, R. J. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105399 · Cited by 51
Degree of Glutathione Deficiency and Redox Imbalance Depend on Subtype of Mitochondrial Disease and Clinical Status
Enns, G. M., Moore, T., Le, A. T., Atkuri, K. R., Shah, M. K., Cusmano‐Ozog, K. P., Niemi, A., & Cowan, T. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100001 · Cited by 49
Real-Time Monitoring of Oxidative Stress in Live Mouse Skin
Wolf, A. M., Nishimaki, K., Kamimura, N., & Ohta, S. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.428 · Cited by 54
A Review of the Potential Role of Nano-Enabled Drug Delivery Technologies in Amyotrophic Lateral Sclerosis: Lessons Learned from Other Neurodegenerative Disorders
Mazibuko, Z., Choonara, Y. E., Kumar, P., du Toit, L. C., Modi, G., Naidoo, D., & Pillay, V. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24322 · Cited by 51
Involvement of the modulation of cancer cell redox status in the anti-tumoral effect of phenolic compounds
Mendes, V., Costa, V., & Mateus, N. F. D. C. B. (2014) · RSC Advances · doi:10.1039/c4ra10590g · Cited by 51
Novel procedures for whole organism detection and quantification of fluorescence as a measurement for oxidative stress in zebrafish (Danio rerio) larvae
Lackmann, C., Santos, M. M., Rainieri, S., Barranco, A., Hollert, H., Špirhanzlová, P., Velki, M., & Seiler, T. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.01.045 · Cited by 51
Involvement of NRF2 in Breast Cancer and Possible Therapeutical Role of Polyphenols and Melatonin
Tascioglu Aliyev, A., Panieri, E., Stepanić, V., Gurer-Orhan, H., & Saso, L. (2021) · Molecules · doi:10.3390/molecules26071853 · Cited by 50
Natural Antioxidants: A Review of Studies on Human and Animal Coronavirus
Diniz, L. R. L., Filho, C. D. S. M. B., Fielding, B. C., & de Sousa, D. P. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3173281 · Cited by 56
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation
Nagasaki, T., Schuyler, A. J., Zhao, J., Самович, С. Н., Yamada, K., Deng, Y., Ginebaugh, S. P., Christenson, S. A., Woodruff, P. G., Fahy, J. V., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 50
Redox‐proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis
Braconi, D., Bianchini, C., Bernardini, G., Laschi, M., Millucci, L., Spreafico, A., & Santucci, A. (2011) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-011-9377-6 · Cited by 50
Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress
Chen, H., Zhou, L., Lin, C.-Y., Beattie, M. C., Liu, J., & Zirkin, B. R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.034 · Cited by 50
Vitamin E assisted polymer electrolyte fuel cells
Yao, Y., Liu, J., Liu, W., Zhao, M., Wu, B., Gu, J., & Zou, Z. (2014) · Energy & Environmental Science · doi:10.1039/c4ee01774a · Cited by 50
Oxidative balance score and risk for incident prostate cancer in a prospective U.S. cohort study
Lakkur, S. S., Goodman, M. G., Bostick, R. M., Citronberg, J. S., McClellan, W., Flanders, W. D., Judd, S. E., & Stevens, V. L. (2014) · Annals of Epidemiology · doi:10.1016/j.annepidem.2014.02.015 · Cited by 50
Dedifferentiation of cancer cells following recovery from a potentially lethal damage is mediated by H2S–Nampt
Ostrakhovitch, E. A., Akakura, S., Sanokawa‐Akakura, R., Goodwin, S., & TABIBZADEH, S. S. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.027 · Cited by 50
Alterations in Redox Homeostasis in the Elite Endurance Athlete
Lewis, N. A., Howatson, G., Morton, K., Hill, J., & Pedlar, C. R. (2014) · Sports Medicine · doi:10.1007/s40279-014-0276-5 · Cited by 50
Thiols and the chemoprevention of cancer
Huber, W. W., & Parzefall, W. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.05.005 · Cited by 50
Specific carotenoid pigments in the diet and a bit of oxidative stress in the recipe for producing red carotenoid-based signals
Blas, E. G., Mateo, R., & Alonso‐Álvarez, C. (2016) · PeerJ · doi:10.7717/peerj.2237 · Cited by 49
Role of oxidative stress-mediated cell death and signaling pathways in experimental fluorosis
Babu, S., Manoharan, S., Ottappilakkil, H., & Perumal, E. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110106 · Cited by 49
New targets for the antitumor activity of gambogic acid in hematologic malignancies
Yang, L., & Chen, Y. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.163 · Cited by 49
Redox regulation of skeletal muscle
Jackson, M. J. (2008) · IUBMB Life · doi:10.1002/iub.72 · Cited by 49
Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS.
Yang, L.-J., Chen, Y., He, J., Yi, S., Wen, L., Zhao, S., & Cui, G. (2012) · Oncology Letters · doi:10.3892/ol.2012.634 · Cited by 46
Endogenous Interleukin-4 Regulates Glutathione Synthesis Following Acetaminophen-Induced Liver Injury in Mice
Ryan, P. M., Bourdi, M., Korrapati, M. C., Proctor, W. R., Vasquez, R. A., Yee, S. B., Quinn, T. D., Chakraborty, M., & Pohl, L. R. (2011) · Chemical Research in Toxicology · doi:10.1021/tx2003992 · Cited by 49
Extracellular redox environments regulate adipocyte differentiation
Imhoff, B. R., & Hansen, J. M. (2010) · Differentiation · doi:10.1016/j.diff.2010.04.005 · Cited by 49
Arginine, N -carbamylglutamate, and glutamine exert protective effects against oxidative stress in rat intestine
Xiao, L., Cao, W., Liu, G., Fang, T., Wu, X., Jia, G., Chen, X., Zhao, H. Y., Wang, J., Wu, C., et al. (2016) · Animal nutrition · doi:10.1016/j.aninu.2016.04.005 · Cited by 49
Dietary effects of Bacillus subtilis fmbj on the antioxidant capacity of broilers at an early age
Zhang, L., Bai, K., Zhang, J., Xu, W., Huang, Q., & Wang, T. Z. (2017) · Poultry Science · doi:10.3382/ps/pex172 · Cited by 49
Amino acids of importance for the antioxidant activity of human serum albumin as revealed by recombinant mutants and genetic variants
Anraku, M., Shintomo, R., Taguchi, K., Kragh‐Hansen, U., Kai, T., Maruyama, T., & Otagiri, M. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.05.010 · Cited by 49
Oxidative stress, oxidative balance score, and hypertension among a racially diverse population
Annor, F. B., Goodman, M. G., Okosun, I. S., Wilmot, D., Il’yasova, D., Ndirangu, M., & Lakkur, S. (2015) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2015.05.014 · Cited by 49
Taurine, Glutathione and Bioenergetics
Hansen, S. H., & Grunnet, N. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6093-0_1 · Cited by 48
Protein adducts of malondialdehyde and 4-hydroxynonenal contribute to trichloroethene-mediated autoimmunity via activating Th17 cells: Dose– and time–response studies in female MRL+/+ mice
Wang, G., Wang, J., Fan, X., Ansari, G. A. S., & Khan, M. F. (2011) · Toxicology · doi:10.1016/j.tox.2011.12.001 · Cited by 47
Fermented papaya preparation as redox regulator in blood cells of β‐thalassemic mice and patients
Amer, J., Goldfarb, A. W., Rachmilewitz, E. A., & Fibach, E. (2008) · Phytotherapy Research · doi:10.1002/ptr.2379 · Cited by 48
The Oxidative Cost of Reproduction: Theoretical Questions and Alternative Mechanisms
Alonso‐Álvarez, C., Canelo, T., & Romero‐Haro, A. Á. (2016) · BioScience · doi:10.1093/biosci/biw176 · Cited by 46
Near-Infrared Fluorescent Probe for the In Situ Visualization of Oxidative Stress in the Brains of Neuroinflammatory and Schizophrenic Mice
Geng, Y., Zhang, H., Zhang, G., Zhou, J., Zhu, M., Ma, L., Wang, X., James, T. D., & Wang, Z. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c01447 · Cited by 47
Si/SiO2 quantum dots cause cytotoxicity in lung cells through redox homeostasis imbalance
Stan, M. S., Memet, I., Sima, C., Popescu, T., Teodorescu, V. S., Hermenean, A. O., & Dinischiotu, A. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.06.020 · Cited by 47
Effects of antioxidant stobadine on protein carbonylation, advanced oxidation protein products and reductive capacity of liver in streptozotocin‐diabetic rats: Role of oxidative/nitrosative stress
Cumaoğlu, A., Çevi̇k, C., Račková, L., Arı, N., & Karasu, Ç. (2007) · BioFactors · doi:10.1002/biof.5520300304 · Cited by 47
Mechanisms of Medial Arterial Calcification in Diabetes
Chistiakov, D. A., Sobenin, I. A., Orekhov, A. N., & Bobryshev, Y. V. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140212210451 · Cited by 49
Does reproduction protect against oxidative stress?
Costantini, D., Casasole, G., & Eens, M. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.114116 · Cited by 47
Passiflora edulis peel intake and ulcerative colitis: Approaches for prevention and treatment
Cazarin, C. B. B., da Silva-Maia, J. K., Colomeu, T. C., Batista, Â. G., Vilella, C. A., Luiz-Ferreira, Â., Bogusz, S., Fukuda, K., Augusto, F., de Meirelles, L. R., et al. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214525306 · Cited by 48
Role of redoximiRs in fibrogenesis
Fierro‐Fernández, M., Miguel, V., & Lamas, S. (2015) · Redox Biology · doi:10.1016/j.redox.2015.11.006 · Cited by 48
Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model
Campos, K. K. D., Ramos, C. D. O., Martins, T. L., Costa, G. D. P., Talvani, A., Garcia, C. C. M., Oliveira, L. A. M., Cangussú, S. D., Costa, D. C., & Bezerra, F. S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.12.008 · Cited by 47
Perfluoroalkyl Acids (PFAAs) Concentrations and Oxidative Status in Two Generations of Great Tits Inhabiting a Contamination Hotspot
López‐Antia, A., Groffen, T., Lasters, R., AbdElgawad, H., Sun, J., Asard, H., Bervoets, L., & Eens, M. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b05235 · Cited by 48
Structural characterization, antioxidant activity, and antiglycation activity of polysaccharides from different chrysanthemum teas
Yuan, Q., Fu, Y., Xiang, P.-Y., Zhao, L., Wang, S., Zhang, Q. R., Liu, Y., Qin, W., Li, D., & Wu, D. (2019) · RSC Advances · doi:10.1039/c9ra05820f · Cited by 47
Glutathione controls the redox state of the mitochondrial carnitine/acylcarnitine carrier Cys residues by glutathionylation
Giangregorio, N., Palmieri, F., & Indiveri, C. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.08.003 · Cited by 46
Roundup ® in Zebrafish: Effects on Oxidative Status and Gene Expression
Velasques, R. R., Sandrini, J. Z., & da Rosa, C. E. (2016) · Zebrafish · doi:10.1089/zeb.2016.1259 · Cited by 46
Synaptic Activity Protects Neurons Against Calcium-Mediated Oxidation and Contraction of Mitochondria During Excitotoxicity
Depp, C., Orth, C. B., Schroeder, L., Hellwig, A., & Bading, H. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7092 · Cited by 46
Oxidative stress assessment in breath-hold diving
Mrakic‐Sposta, S., Vezzoli, A., Rizzato, A., Noce, C. D., Malacrida, S., Montorsi, M., Paganini, M., Cancellara, P., & Bosco, G. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04224-4 · Cited by 46
Circadian Clocks, Redox Homeostasis, and Exercise: Time to Connect the Dots?
McClean, C. M., & Davison, G. W. (2022) · Antioxidants · doi:10.3390/antiox11020256 · Cited by 46
Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition.
He, M., Cai, J.-Y., Go, Y., Johnson, J. M., Martin, W. D., Hansen, J. M., & Jones, D. P. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn116 · Cited by 48
Self-citation
Plasmonic optical fiber biosensor development for point-of-care detection of malondialdehyde as a biomarker of oxidative stress
Bencivenga, D., Arcadio, F., Piccirillo, A., Annunziata, M., Ragione, F. D., Cennamo, N., Borriello, A., Zeni, L., & Guida, L. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.02.020 · Cited by 47
Quantification of Redox Conditions in the Nucleus
Go, Y., Pohl, J., & Jones, D. P. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-461-6_17 · Cited by 45
Self-citation
The Level of an Intracellular Antioxidant during Development Determines the Adult Phenotype in a Bird Species: A Potential Organizer Role for Glutathione
Romero‐Haro, A. Á., & Alonso‐Álvarez, C. (2015) · The American Naturalist · doi:10.1086/679613 · Cited by 45
5′-AMP-Activated Protein Kinase Attenuates Adriamycin-Induced Oxidative Podocyte Injury through Thioredoxin-Mediated Suppression of the Apoptosis Signal-Regulating Kinase 1–P38 Signaling Pathway
Gao, K., Chi, Y., Sun, W., Takeda, M., & Yao, J. Q. (2014) · Molecular Pharmacology · doi:10.1124/mol.113.089458 · Cited by 47
HIV-1, reactive oxygen species, and vascular complications
Porter, K. M., & Sutliff, R. L. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.019 · Cited by 45
Blood markers of oxidative stress are strongly associated with poorer prognosis in colorectal cancer patients
Boakye, D., Jansen, L., Schöttker, B., Jansen, E. H. J. M., Schneider, M. A., Halama, N., Gao, X. Y., Chang-Claude, J. C., Hoffmeister, M., & Brenner, H. (2020) · International Journal of Cancer · doi:10.1002/ijc.33018 · Cited by 45
Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death
Hoffmann, L., Waclawczyk, M. S., Tang, S., Hanschmann, E.-M., Gellert, M., Rust, M. B., & Culmsee, C. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04242-1 · Cited by 45
Chemotherapeutic drugs induce oxidative stress associated with DNA repair and metabolism modulation
Zhang, Y., Ding, C., Zhu, W., Li, X., Chen, T., Liu, Q., Zhou, S., Zhang, T., & Ma, W. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120242 · Cited by 48
The Importance of Multifaceted Approach for Accurate and Comprehensive Evaluation of Oxidative Stress Status in Biological Systems
Poljšak, B., Jamnik, P., & Milisav, I. (2025) · Antioxidants · doi:10.3390/antiox14091083 · Cited by 52
Redox control of cardiac remodeling in atrial fibrillation
Wolke, C., Bukowska, A., Goette, A., & Lendeckel, U. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.12.012 · Cited by 43
Dual-energy precursor and nuclear erythroid–related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species
Ghosh, D., LeVault, K. R., & Brewer, G. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.023 · Cited by 43
Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis
Zhu, S., Mąkosa, D., Miller, B. F., & Griffin, T. M. (2019) · Connective Tissue Research · doi:10.1080/03008207.2019.1665035 · Cited by 44
Nutraceuticals and Exercise against Muscle Wasting during Cancer Cachexia
Aquila, G., Cecconi, A. D. R., Brault, J. J., Corli, O., & Piccirillo, R. (2020) · Cells · doi:10.3390/cells9122536 · Cited by 46
Polystyrene nanoplastics change the functional traits of biofilm communities in freshwater environment revealed by GeoChip 5.0
Miao, L., Guo, S., Wu, J. F., Adyel, T. M., Liu, Z., Liu, S., & Hou, J. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127117 · Cited by 44
S-Glutathionylation and S-Nitrosylation in Mitochondria: Focus on Homeostasis and Neurodegenerative Diseases
Vrettou, S., & Wirth, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415849 · Cited by 45
The basic chemistry of exercise-induced DNA oxidation: oxidative damage, redox signaling, and their interplay
Cobley, J. N., Margaritelis, N. V., Morton, J. P., Close, G. L., Nikolaidis, M. G., & Malone, J. K. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00182 · Cited by 43
Prevention of Oxidative Stress and Diseases by Antioxidant Supplementation
Martemucci, G., Portincasa, P., Centonze, V., Mariano, M., Khalil, M., & D‘Alessandro, A. G. (2022) · Medicinal Chemistry · doi:10.2174/1573406419666221130162512 · Cited by 48
A fluorophore anchored MOF for fast and sensitive sensing of Cu( ii ) and 3-nitrotyrosine in a physiological medium
Mukherjee, S., Sarkar, K., & Biswas, S. (2023) · Dalton Transactions · doi:10.1039/d3dt00660c · Cited by 43
Redox control of antioxidants, metabolism, immunity, and development at the core of stress adaptation of the oyster Crassostrea gigas to the dynamic intertidal environment
Trevisan, R., & Mello, D. F. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.11.003 · Cited by 47
Potential Role of the Gut/Liver/Lung Axis in Alcohol-Induced Tissue Pathology
Massey, V. L., Beier, J. I., Ritzenthaler, J. D., Roman, J., & Arteel, G. E. (2015) · Biomolecules · doi:10.3390/biom5042477 · Cited by 45
Antioxidant Effect of Cysteamine in Brain Cortex of Young Rats
Kessler, A., Biasibetti, M., Melo, D. A. D. S., Wajner, M., Dutra‐Filho, C. S., Wyse, Â. T. D. S., & Wannmacher, C. M. D. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9486-7 · Cited by 44
Toxic stress, inflammation and symptomatology of chronic complications in diabetes
Downs, C. A., & Faulkner, M. S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i4.554 · Cited by 42
Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance
Bevinakoppamath, S., Ramachandra, S. C., Yadav, A. K., Basavaraj, V., Vishwanath, P., & Prashant, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.719631 · Cited by 42
A meta-analysis on the toxicity of microcystin-LR to fish and mammals
Zhang, H., Zhao, X., Li, Y., & Xie, P. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121780 · Cited by 42
Oxygen in human health from life to death – An approach to teaching redox biology and signaling to graduate and medical students
Briehl, M. M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.04.002 · Cited by 41
Antioxidant and toxicological effects elicited by alpha-lipoic acid in aquatic organisms
Kütter, M. T., Romano, L. A., Ventura‐Lima, J., Tesser, M. B., & Monserrat, J. M. (2014) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2014.03.008 · Cited by 43
The cystathionine γ-lyase/hydrogen sulfide system maintains cellular glutathione status
Lee, Z., Low, Y.-L., Huang, S., Wang, T., & Deng, L. (2014) · Biochemical Journal · doi:10.1042/bj20131434 · Cited by 42
Oxidative Stress Regulation on Endothelial Cells by Hydrophilic Astaxanthin Complex: Chemical, Biological, and Molecular Antioxidant Activity Evaluation
Tamayo, M. Z., Barzegari, A., Letourneur, D., Gueguen, V., & Pavon‐Djavid, G. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8073798 · Cited by 42
Fasting ameliorates oxidative stress: A review of physiological strategies across life history events in wild vertebrates
Ensminger, D. C., Salvador‐Pascual, A., Arango, B. G., Allen, K. N., & Vázquez‐Medina, J. P. (2021) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2021.110929 · Cited by 45
Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus
Guarneri, F., Bertino, L., Pioggia, G., Casciaro, M., & Gangemi, S. (2021) · Antioxidants · doi:10.3390/antiox10071087 · Cited by 45
Mitochondrial aldehyde dehydrogenase prevents ROS-induced vascular contraction in angiotensin-II hypertensive mice
Choi, H., Tostes, R. C., & Webb, R. C. (2011) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2011.02.005 · Cited by 42
Clinical assay of four thiol amino acid redox couples by LC–MS/MS: Utility in thalassemia
Suh, J. H., Kim, R., Yavuz, B., Lee, D., Lal, A., Ames, B. N., & Shigenaga, M. K. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.06.041 · Cited by 42
Balanced basal-levels of ROS (redox-biology), and very-low-levels of pro-inflammatory cytokines (cold-inflammaging), as signaling molecules can prevent or slow-down overt-inflammaging, and the aging-associated decline of adaptive-homeostasis
Wei, Y., Jia, S., Ding, Y., Xia, S., & Giunta, S. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.112067 · Cited by 43
Hormesis, allostatic buffering capacity and physiological mechanism of physical activity: A new theoretic framework
Li, G., & He, H. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.12.037 · Cited by 41
Integrated Approach to Immunotoxicity: Electron Transfer, Reactive Oxygen Species, Antioxidants, Cell Signaling, and Receptors
Kovacic, P., & Somanathan, R. (2008) · Journal of Receptors and Signal Transduction · doi:10.1080/10799890802305217 · Cited by 41
Oxidative stress is associated with decreased heart rate variability in patients with chronic kidney disease
Fadaee, S. B., Beetham, K. S., Howden, E. J., Stanton, T., Isbel, N. M., & Coombes, J. S. (2016) · Redox Report · doi:10.1080/13510002.2016.1173326 · Cited by 41
Short-term and long-term effects of transient exogenous cortisol manipulation on oxidative stress in juvenile brown trout
Birnie‐Gauvin, K., Peiman, K. S., Larsen, M. H., Aarestrup, K., Willmore, W. G., & Cooke, S. J. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.155465 · Cited by 41
Oxidative Stress and Microcirculatory Flow Abnormalities in the Ventricles during Atrial Fibrillation
Goette, A., Bukowska, A., Lillig, C. H., & Lendeckel, U. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00236 · Cited by 42
Segment-specific overexpression of redoxins after renal ischemia and reperfusion: protective roles of glutaredoxin 2, peroxiredoxin 3, and peroxiredoxin 6
Godoy, J. R., Oesteritz, S., Hanschmann, E.-M., Ockenga, W., Ackermann, W., & Lillig, C. H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.036 · Cited by 40
The Mediterranean dietary pattern for optimising health and performance in competitive athletes: a narrative review
Griffiths, A., Matu, J., Whyte, E., Akin-Nibosun, P., Clifford, T., Stevenson, E., & Shannon, O. M. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521003202 · Cited by 46
Relationship between inflammation and oxidative stress and its effect on multiple sclerosis
Ramos-González, E. J., Bitzer-Quintero, O. K., Ortíz, G. G., Hernández-Cruz, J. J., & Ramírez-Jirano, L. J. (2024) · Neurología (English Edition) · doi:10.1016/j.nrleng.2021.10.010 · Cited by 48
Oxidative stress predicts long-term resight probability and reproductive success in Scopoli's shearwater (Calonectris diomedea)
Costantini, D., & Dell’Omo, G. (2015) · Conservation Physiology · doi:10.1093/conphys/cov024 · Cited by 40
Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation
Assiri, M. A., Roy, S. R., Harris, P. S., Ali, H., Liang, Y., Shearn, C. T., Orlicky, D. J., Roede, J. R., Hirschey, M. D., Backos, D. S., et al. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13473 · Cited by 40
Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease
Grady, S. T., Koutrakis, P., Hart, J. E., Coull, B. A., Schwartz, J. D., Laden, F., Zhang, J. J., Gong, J., Moy, M. L., & Garshick, E. (2018) · Environment International · doi:10.1016/j.envint.2018.02.040 · Cited by 39
Over 3 decades of research on dietary flavonoid antioxidants and cancer prevention: What have we achieved?
Alfa, H. H., & Arroo, R. (2019) · Phytochemistry Reviews · doi:10.1007/s11101-019-09632-0 · Cited by 40
The Impact of Medium Chain and Polyunsaturated ω-3-Fatty Acids on Amyloid-β Deposition, Oxidative Stress and Metabolic Dysfunction Associated with Alzheimer’s Disease
Mett, J. (2021) · Antioxidants · doi:10.3390/antiox10121991 · Cited by 43
Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine
Correia, M. J., Pimpão, A. B., Fernandes, D., Morelló, J., Sequeira, C. O., Calado, J., Antunes, A. M. M., Almeida, M., Branco, P. Q., Monteiro, E. C., et al. (2022) · Molecules · doi:10.3390/molecules27041416 · Cited by 40

Authors: Jones, D. P.
Affiliations: Emory University (US)
Corresponding author: Jones, Dean P.
ORCID: Jones, Dean P.
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2006-09
Volume: 8
Issue: 9-10
Pages: 1865-1879
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2006.8.1865
OpenAlex: W1970240791
Semantic Scholar: 21aa29343a7c35ad93ce5d00685d8074eb1f4efa
Cited by: 1,726
References: 66
Citations by year: 2026: 94 · 2025: 51 · 2024: 84 · 2023: 92 · 2022: 96 · 2021: 109 · 2020: 97 · 2019: 87 · 2018: 100 · 2017: 87 · 2016: 105 · 2015: 90 · 2014: 109 · 2013: 89 · 2012: 109
FWCI: 4.16
Type: journal article
Language: en
Open access: closed
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Environmental Health Sciences (R01ES009047, R01-ES-09047, R01ES011195)
National Center for Research Resources (M01-RR00039, M01RR000039)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Keywords: oxidative stress, redox signaling, glutathione, glutathione disulfide, thioredoxin, thiol-disulfide balance, redox equilibria, redox regulation
MeSH terms: Animals, Cysteine, Cystine, Glutathione, Humans, Models, Biological, Oxidation-Reduction, Signal Transduction, Oxidative Stress, Glutathione Disulfide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Redefining Oxidative Stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks