Oxidative Stress and Vascular Disease

Madamanchi, Nageswara R.; Vendrov, Aleksandr; Runge, Marschall S.

doi:10.1161/01.atv.0000150649.39934.13

Cited by 1,618Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

Oxidative Stress and Vascular Disease

Madamanchi, Nageswara R., Vendrov, Aleksandr, Runge, Marschall S.·2005·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/01.atv.0000150649.39934.13

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Abstract

Growing evidence indicates that chronic and acute overproduction of reactive oxygen species (ROS) under pathophysiologic conditions is integral in the development of cardiovascular diseases (CVD). These ROS can be released from nicotinamide adenine dinucleotide (phosphate) oxidase, xanthine oxidase, lipoxygenase, mitochondria, or the uncoupling of nitric oxide synthase in vascular cells. ROS mediate various signaling pathways that underlie vascular inflammation in atherogenesis: from the initiation of fatty streak development through lesion progress to ultimate plaque rupture. Various animal models of oxidative stress support the notion that ROS have a causal role in atherosclerosis and other cardiovascular diseases. Human investigations also support the oxidative stress hypothesis of atherosclerosis. Oxidative stress is the unifying mechanism for many CVD risk factors, which additionally supports its central role in CVD. Despite the demonstrated role of antioxidants in cellular and animal studies, the ineffectiveness of antioxidants in reducing cardiovascular death and morbidity in clinical trials has led many investigators to question the importance of oxidative stress in human atherosclerosis. Others have argued that the prime factor for the mixed outcomes from using antioxidants to prevent CVD may be the lack of specific and sensitive biomarkers by which to assess the oxidative stress phenotypes underlying CVD. A better understanding of the complexity of cellular redox reactions, development of a new class of antioxidants targeted to specific subcellular locales, and the phenotype-genotype linkage analysis for oxidative stress will likely be avenues for future research in this area as we move toward the broader use of pharmacological and regenerative therapies in the treatment and prevention of CVD.

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Peroxynitrite can traverse cell membranes by both diffusion and through ion channels.
“Additionally, studies show peroxynitrite can traverse cell membranes by both diffusion and through ion channels, suggesting that peroxynitrite can mediate oxidation/nitration distant from its site of formation (221, 611).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [611]
Peroxynitrite can mediate oxidation/nitration distant from its site of formation.
“Additionally, studies show peroxynitrite can traverse cell membranes by both diffusion and through ion channels, suggesting that peroxynitrite can mediate oxidation/nitration distant from its site of formation (221, 611).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [611]

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Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271 · see citing works
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791 · see citing works
Untitled work
Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329 · see citing works
Mitochondrial diseases in man and mouse
Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060 · see citing works
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886 · see citing works
Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal Transduction
Sundaresan, M., Yu, Z.-X., Ferrans, V. J., Irani, K., & Finkel, T. (1995) · Science · doi:10.1126/science.270.5234.296 · Cited by 2,520 · see citing works
Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)
Stephens, N. G., Parsons, A., Brown, M. J., Schofield, P. M., Kelly, F., Cheeseman, K., & Mitchinson, M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90866-1 · Cited by 2,148 · see citing works
NADPH Oxidase: An Update
BABIOR, B. M. (1999) · Blood · doi:10.1182/blood.v93.5.1464 · Cited by 2,147 · see citing works
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765 · see citing works
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660 · see citing works
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652 · see citing works
Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain
Chan, P. H. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200101000-00002 · Cited by 1,589 · see citing works
Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase
Huang, Z., Huang, P. L., Panahian, N., Dalkara, T., Fishman, M. C., & Moskowitz, M. A. (1994) · Science · doi:10.1126/science.7522345 · Cited by 1,562 · see citing works
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484 · see citing works
Cell transformation by the superoxide-generating oxidase Mox1
Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480 · see citing works
The Haber–Weiss reaction and mechanisms of toxicity
Kehrer, J. P. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00231-6 · Cited by 1,418 · see citing works
Increase in Circulating Products of Lipid Peroxidation (F2-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage
Morrow, J. D., Frei, B. B., Longmire, A. W., Gaziano, J. M., Lynch, S. M., Shyr, Y., Strauss, W., Oates, J. A., & Roberts, L. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505043321804 · Cited by 1,340 · see citing works
Obesity and Systemic Oxidative Stress: Clinical Correlates of Oxidative Stress in The Framingham Study
Keaney, J. F., Larson, M. G., Vasan, R. S., Wilson, P. W. F., Lipinska, I., Corey, D., Massaro, J. M., Sutherland, P., Vita, J. A., & Benjamin, E. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000058402.34138.11 · Cited by 1,304 · see citing works
Role of oxidative stress in atherosclerosis
Harrison, D., Griendling, K. K., Landmesser, U., Hornig, B., & Drexler, H. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03144-2 · Cited by 1,275 · see citing works
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
Hink, U., Li, H., Mollnau, H., Oelze, M., Matheis, E., Hartmann, M., Skatchkov, M. P., Thaiss, F., Stahl, R. A. K., Warnholtz, A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.2.e14 · Cited by 1,176 · see citing works
Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.
Cushing, S. D., Berliner, J. A., Valente, A. J., Territo, M., Navab, M., Parhami, F., Gerrity, R. G., Schwartz, C. J., & Fogelman, A. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5134 · Cited by 1,147 · see citing works
Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.
Rajagopalan, S., Meng, X. P., Ramasamy, S., Harrison, D. G., & Galis, Z. S. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119076 · Cited by 1,137 · see citing works
Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial
Boaz, M., Smetana, S. S., Weinstein, T., Matas, Z., Gafter, U., Iaina, A., Knecht, A., Weissgarten, Y., Brunner, D., FAINARU, M., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02783-5 · Cited by 1,021 · see citing works
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00687.1998 · Cited by 863 · see citing works
Intensive Diabetes Therapy and Carotid Intima–Media Thickness in Type 1 Diabetes Mellitus
(2003) · New England Journal of Medicine · doi:10.1056/nejmoa022314 · Cited by 815 · see citing works
Vitamin C exhibits pro-oxidant properties
Podmore, I. D., Griffiths, H. R., Herbert, K. E., Mistry, N., Mistry, P., & Lunec, J. (1998) · Nature · doi:10.1038/33308 · Cited by 800 · see citing works
Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins
Rajavashisth, T. B., Andalibi, A., Territo, M., Berliner, J. A., Navab, M., Fogelman, A. M., & Lusis, A. J. (1990) · Nature · doi:10.1038/344254a0 · Cited by 775 · see citing works
p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells
Ushio‐Fukai, M., Zafari, A. M., Fukui, T., Ishizaka, N., & Griendling, K. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23317 · Cited by 766 · see citing works
In Vivo Formation of 8-Iso-Prostaglandin F2αand Platelet Activation in Diabetes Mellitus: Effects of Improved Metabolic Control and Vitamin E Supplementation
Davı̀, G., Ciabattoni, G., Consoli, A., Mezzetti, A., Falco, A., Santarone, S., Pennese, E., Vitacolonna, E., Bucciarelli, T., Costantini, F., et al. (1999) · Circulation · doi:10.1161/01.cir.99.2.224 · Cited by 742 · see citing works
Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin
Laursen, J. B., Somers, M., Kurz, S., McCann, L., Warnholtz, A., Freeman, B. A., Tarpey, M., Fukai, T., & Harrison, D. G. (2001) · Circulation · doi:10.1161/01.cir.103.9.1282 · Cited by 721 · see citing works
Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine
Huang, Z., Huang, P. L., Ma, J., Meng, W., Ayata, C., Fishman, M. C., & Moskowitz, M. A. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00023 · Cited by 718 · see citing works
Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium
Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., Uchida, K., Arimura, K., Egashira, K., & Takeshita, A. (1999) · Circulation Research · doi:10.1161/01.res.85.4.357 · Cited by 702 · see citing works
The Yin and Yang of Oxidation in the Development of the Fatty Streak
Navab, M., Berliner, J. A., Watson, A. D., Hama, S. Y., Territo, M., Lusis, A. J., Shih, D. M., Lenten, B. J. V., Frank, J. S., Demer, L. L., et al. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.7.831 · Cited by 699 · see citing works
Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis
Warnholtz, A., Nickenig, G., Schulz, E., Macharzina, R. R., Bräsen, J. H., Skatchkov, M. P., Heitzer, T. A., Stasch, J. P., Griendling, K. K., Harrison, D. G., et al. (1999) · Circulation · doi:10.1161/01.cir.99.15.2027 · Cited by 676 · see citing works
Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene
Iadecola, C., Zhang, F., Casey, R., Nagayama, M., & Ross, M. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09157.1997 · Cited by 661 · see citing works
Role of ubiquinone in the mitochondrial generation of hydrogen peroxide
Boveris, A., Cadenas, E., & Stoppani, A. O. M. (1976) · Biochemical Journal · doi:10.1042/bj1560435 · Cited by 655 · see citing works
The antioxidant paradox
Halliwell, B. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02075-4 · Cited by 655 · see citing works
Expression of Angiotensin II and Interleukin 6 in Human Coronary Atherosclerotic Plaques
Schieffer, B., Schieffer, E., Hilfiker‐Kleiner, D., Hilfiker, A., Kovanen, P. T., Kaartinen, M., Nussberger, J., Harringer, W., & Drexler, H. (2000) · Circulation · doi:10.1161/01.cir.101.12.1372 · Cited by 654 · see citing works
Oxygen radical mechanisms of brain injury following ischemia and reperfusion
Traystman, R. J., Kirsch, J. R., & Koehler, R. C. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.4.1185 · Cited by 653 · see citing works
Correction of Arterial Structure and Endothelial Dysfunction in Human Essential Hypertension by the Angiotensin Receptor Antagonist Losartan
Schiffrin, E. L., Park, J. B., Intengan, H. D., & Touyz, R. M. (2000) · Circulation · doi:10.1161/01.cir.101.14.1653 · Cited by 617 · see citing works
Role of NADH/NADPH Oxidase–Derived H 2 O 2 in Angiotensin II–Induced Vascular Hypertrophy
Zafari, A. M., Ushio‐Fukai, M., Akers, M., Yin, Q., Shah, A. A., Harrison, D. G., Taylor, W. R., & Griendling, K. K. (1998) · Hypertension · doi:10.1161/01.hyp.32.3.488 · Cited by 610 · see citing works
Novel Competitive Inhibitor of NAD(P)H Oxidase Assembly Attenuates Vascular O2−and Systolic Blood Pressure in Mice
Rey, F. E., Cifuentes-Pagano, E., Kiarash, A., Quinn, M. T., & Pagano, P. J. (2001) · Circulation Research · doi:10.1161/hh1701.096037 · Cited by 606 · see citing works
Increased myocardial NADPH oxidase activity in human heart failure
Heymes, C., Bendall, J. K., Ratajczak, P., Cave, A. C., Samuel, J., Hasenfuss, G. P., & Shah, A. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00471-6 · Cited by 582 · see citing works
Role of p47 phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II
Landmesser, U., Cai, H. “., Dikalov, S., McCann, L. A., Hwang, J., Jo, H., Holland, S. M., & Harrison, D. G. (2002) · Hypertension · doi:10.1161/01.hyp.0000032100.23772.98 · Cited by 572 · see citing works
Lipid advanced glycosylation: pathway for lipid oxidation in vivo.
Bucala, R., Makita, Z., Koschinsky, T., Cerami, A., & Vlassara, H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6434 · Cited by 571 · see citing works
Platelet Activation in Obese Women
Davı̀, G., Guagnano, M. T., Ciabattoni, G., Basili, S., Falco, A., Marinopiccoli, M., Nutini, M., Sensi, S., & Patrono, C. (2002) · JAMA · doi:10.1001/jama.288.16.2008 · Cited by 542 · see citing works
NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium
Mohazzab, K. M., Kaminski, P. M., & Wolin, M. S. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.6.h2568 · Cited by 536 · see citing works
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
Cyrus, T., Witztum, J. L., Rader, D. J., Tangirala, R., Fazio, S., Linton, M. F., & Funk, C. D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5897 · Cited by 523 · see citing works
Activation of NADPH Oxidase During Progression of Cardiac Hypertrophy to Failure
Li, J., Gall, N. P., Grieve, D., Chen, M., & Shah, A. M. (2002) · Hypertension · doi:10.1161/01.hyp.0000032031.30374.32 · Cited by 517 · see citing works
Inhibitory Effects of Antioxidants on Neonatal Rat Cardiac Myocyte Hypertrophy Induced by Tumor Necrosis Factor-α and Angiotensin II
Nakamura, K., Fushimi, K., Kouchi, H., Mihara, K., Miyazaki, M., Ohe, T., & Namba, M. (1998) · Circulation · doi:10.1161/01.cir.98.8.794 · Cited by 510 · see citing works
p47phox is required for atherosclerotic lesion progression in ApoE–/– mice
Barry-Lane, P. A., Patterson, C., van der Merwe, M., Hu, Z., Holland, S. M., Yeh, E. T. H., & Runge, M. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200111927 · Cited by 489 · see citing works
Self-citation
Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function
Milstien, S., & Katušić, Z. S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1422 · Cited by 488 · see citing works
Mitochondrial Integrity and Function in Atherogenesis
Ballinger, S. W., Patterson, C., Knight-Lozano, C. A., Burow, D. L., Conklin, C. A., Hu, Z., Reuf, J., Horaist, C., Lebovitz, R. M., Hunter, G. C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000023921.93743.89 · Cited by 478 · see citing works
Self-citation
Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid
Frei, B. B., Forte, T. M., Ames, B. N., & Cross, C. E. (1991) · Biochemical Journal · doi:10.1042/bj2770133 · Cited by 471 · see citing works
Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency
Murakami, K., Kondo, T., 川瀬, 誠., Li, Y., Sato, S., Chen, S. F., & Chan, P. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00205.1998 · Cited by 467 · see citing works
Peroxynitrite Is a Major Contributor to Cytokine-Induced Myocardial Contractile Failure
Ferdinandy, P., Danial, H., Ambrus, I., Rothery, R. A., & Schulz, R. (2000) · Circulation Research · doi:10.1161/01.res.87.3.241 · Cited by 457 · see citing works
Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II
Pagano, P. J., Clark, J. K., Cifuentes-Pagano, M. E., Clark, S. M., Callis, G. M., & Quinn, M. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14483 · Cited by 455 · see citing works
HMG-CoA Reductase Inhibitors Improve Endothelial Dysfunction in Normocholesterolemic Hypertension via Reduced Production of Reactive Oxygen Species
Waßmann, S., Laufs, U., Bäumer, A. T., Müller, K., Ahlbory, K., Linz, W., Itter, G., Rösen, R., Böhm, M., & Nickenig, G. (2001) · Hypertension · doi:10.1161/01.hyp.37.6.1450 · Cited by 453 · see citing works
TRANSCRIPTION OF THE MAMMALIAN MITOCHONDRIAL GENOME
Clayton, D. A. (1984) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.53.070184.003041 · Cited by 446 · see citing works
Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury
Szöcs, K., Lassegue, B. P., Sorescu, D., Hilenski, L. L., Valppu, L., Couse, T. L., Wilcox, J. N., Quinn, M. T., Lambeth, J. D., & Griendling, K. K. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.102189 · Cited by 444 · see citing works
Hydrogen Peroxide– and Peroxynitrite-Induced Mitochondrial DNA Damage and Dysfunction in Vascular Endothelial and Smooth Muscle Cells
Ballinger, S. W., Patterson, C., Yan, C.-N., Doan, R., Burow, D. L., Young, C. G., Yakes, F. M., Houten, B. V., Ballinger, C. A., Freeman, B. Α., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.9.960 · Cited by 442 · see citing works
Self-citation
Paraoxonase Status in Coronary Heart Disease
Mackness, B., Davies, G. K., Turkie, W., Lee, E., Roberts, D. H., Hill, E., Roberts, C., Durrington, P. N., & Mackness, M. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0901.094247 · Cited by 436 · see citing works
Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
Heitzer, T., Krohn, K., Albers, S., & Meinertz, T. (2000) · Diabetologia · doi:10.1007/s001250051551 · Cited by 427 · see citing works
Expression of phagocyte NADPH oxidase components in human endothelial cells
Jones, S. A., O’Donnell, V. B., Wood, J. D., Broughton, J. P., Hughes, E. J., & Jones, O. T. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.4.h1626 · Cited by 427 · see citing works
Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment
Maack, C., Kartes, T., Kilter, H., Schäfers, H., Nickenig, G., Böhm, M., & Laufs, U. (2003) · Circulation · doi:10.1161/01.cir.0000091084.46500.bb · Cited by 424 · see citing works
Combined Serum Paraoxonase Knockout/Apolipoprotein E Knockout Mice Exhibit Increased Lipoprotein Oxidation and Atherosclerosis
Shih, D. M., Xia, Y.-R., Wang, X.-P., Miller, E. R., Castellani, L. W., Subbanagounder, G., Cheroutre, H., Faull, K. F., Berliner, J. A., Witztum, J. L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910376199 · Cited by 423 · see citing works
Mechanical Stretch Enhances mRNA Expression and Proenzyme Release of Matrix Metalloproteinase-2 (MMP-2) via NAD(P)H Oxidase–Derived Reactive Oxygen Species
Grote, K., Flach, I., Luchtefeld, M., Akin, E., Holland, S. M., Drexler, H., & Schieffer, B. (2003) · Circulation Research · doi:10.1161/01.res.0000077044.60138.7c · Cited by 417 · see citing works
Oxidative Stress in Arterial Hypertension
Zalba, G., José, G. S., Moreno, M. U., Fortuño, M. A., Fortuño, A., Beaumont, J., & Dı́ez, J. (2001) · Hypertension · doi:10.1161/hy1201.099611 · Cited by 410 · see citing works
Reactive Oxygen Species, Mitochondria, and NAD(P)H Oxidases in the Development and Progression of Heart Failure
Sorescu, D., & Griendling, K. K. (2002) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2002.00717.x · Cited by 403 · see citing works
Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progression
Salonen, R. M., Nyyssönen, K., Kaikkonen, J., Porkkala-Sarataho, E., Voutilainen, S., Rissanen, T. H., Tuomainen, T., Valkonen, V.-P., Ristonmaa, U., Lakka, H., et al. (2003) · Circulation · doi:10.1161/01.cir.0000050626.25057.51 · Cited by 382 · see citing works
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Nickenig, G., & Harrison, D. G. (2002) · Circulation · doi:10.1161/hc0302.102618 · Cited by 368 · see citing works
Novel homologs of gp91phox
Lambeth, J. D., Cheng, G., Arnold, R. S., & Edens, W. A. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01658-3 · Cited by 355 · see citing works
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Waßmann, S., Laufs, U., Bäumer, A. T., Müller, K., Konkol, C., Sauer, H., Böhm, M., & Nickenig, G. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.3.646 · Cited by 340 · see citing works
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Hwang, J., Ing, M. H., Salazar, A. M., Lassegue, B. P., Griendling, K. K., Navab, M., Sevanian, A., & Hsiai, T. K. (2003) · Circulation Research · doi:10.1161/01.res.0000104087.29395.66 · Cited by 332 · see citing works
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Patterson, C., Ruef, J., Madamanchi, N. R., Barry-Lane, P., Hu, Z., Horaist, C., Ballinger, C. A., Brasier, A. R., Bode, C., & Runge, M. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19814 · Cited by 330 · see citing works
Self-citation
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Tan, K. C. B., Chow, W.-S., Ai, V. H. G., Metz, C. N., Bucala, R., & Lam, K. S. L. (2002) · Diabetes Care · doi:10.2337/diacare.25.6.1055 · Cited by 318 · see citing works
Thrombin receptor expression in normal and atherosclerotic human arteries.
Nelken, N. A., Soifer, S. J., O’Keeffe, J., Vu, T. K., Charo, I. F., & Coughlin, S. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116031 · Cited by 314 · see citing works
Ascorbate Restores Endothelium-Dependent Vasodilation Impaired by Acute Hyperglycemia in Humans
Beckman, J. A., Goldfine, A. B., Gordon, M. B., & Creager, M. A. (2001) · Circulation · doi:10.1161/01.cir.103.12.1618 · Cited by 314 · see citing works
Manganese Superoxide Dismutase Mediates the Early Release of Mitochondrial Cytochrome C and Subsequent DNA Fragmentation after Permanent Focal Cerebral Ischemia in Mice
Fujimura, M., Morita‐Fujimura, Y., 川瀬, 誠., Copin, J., Calagui, B., Epstein, C. J., & Chan, P. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03414.1999 · Cited by 309 · see citing works
Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle
KEULENAER, W. G. D., Alexander, R. W., Ushio‐Fukai, M., Ishizaka, N., & Griendling, K. K. (1998) · Biochemical Journal · doi:10.1042/bj3290653 · Cited by 308 · see citing works
Electron Spin Resonance Characterization of Vascular Xanthine and NAD(P)H Oxidase Activity in Patients With Coronary Artery Disease
Spiekermann, S., Landmesser, U., Dikalov, S., Bredt, M., Gamez, G., Tatge, H., Reepschläger, N., Hornig, B., Drexler, H., & Harrison, D. G. (2003) · Circulation · doi:10.1161/01.cir.0000056762.69302.46 · Cited by 298 · see citing works
Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial
Fang, J. C.-T., Kinlay, S., Beltrame, J. F., Hikiti, H., Wainstein, M. V., Behrendt, D., Suh, J. H., Frei, B. B., Mudge, G. H., Selwyn, A. P., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08154-0 · Cited by 293 · see citing works
Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice
Rozenberg, O. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01429-6 · Cited by 282 · see citing works
Assessment of chlorination by human neutrophils
Foote, C. S., Goyne, T. E., & Lehrer, R. I. (1983) · Nature · doi:10.1038/301715a0 · Cited by 281 · see citing works
c-Src Induces Phosphorylation and Translocation of p47phox
Touyz, R. M., Yao, G., & Schiffrin, E. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000069236.27911.68 · Cited by 269 · see citing works
Mechanisms of hypochlorite injury of target cells.
Schraufstätter, I. U., Browne, K. A., Harris, A., Hyslop, P. A., Jackson, J. H., Quehenberger, O., & Cochrane, C. G. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114472 · Cited by 266 · see citing works
Intravenous Allopurinol Decreases Myocardial Oxygen Consumption and Increases Mechanical Efficiency in Dogs With Pacing-Induced Heart Failure
Ekelund, U. E. G., Harrison, R. W., Shokek, O., Thakkar, R. N., Tunin, R. S., Senzaki, H., Kass, D. A., Marbán, E., & Hare, J. M. (1999) · Circulation Research · doi:10.1161/01.res.85.5.437 · Cited by 239 · see citing works
Leukocyte—endothelial cell interactions
McEver, R. P. (1992) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(92)90109-p · Cited by 238 · see citing works
Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients
Koh, K. K., Ahn, J. Y., Han, S. H., Kim, D. S., Jin, D., Kim, H. S., Shin, M., Ahn, T. H., Choi, I. S., & Shin, E. K. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00846-5 · Cited by 225 · see citing works
Acute Amelioration of Diabetic Endothelial Dysfunction with a Derivative of the Nitric Oxide Synthase Cofactor, Tetrahydrobiopterin
Pieper, G. M. (1997) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199701000-00002 · Cited by 222 · see citing works
Effect of Native and Oxidized Low-Density Lipoprotein on Endothelial Nitric Oxide and Superoxide Production
Vergnani, L., Hatrik, S., Ricci, F., Passaro, A., Manzoli, N., Zuliani, G., Brovkovych, V. M., Fellin, R., & Maliñski, T. (2000) · Circulation · doi:10.1161/01.cir.101.11.1261 · Cited by 219 · see citing works
Cigarette Smoke Exposure and Hypercholesterolemia Increase Mitochondrial Damage in Cardiovascular Tissues
Knight-Lozano, C. A., Young, C. G., Burow, D. L., Hu, Z., Uyeminami, D. L., Pinkerton, K. E., Ischiropoulos, H., & Ballinger, S. W. (2002) · Circulation · doi:10.1161/hc0702.103977 · Cited by 217 · see citing works
Increased infarct size and exacerbated apoptosis in the glutathione peroxidase‐1 (Gpx‐1) knockout mouse brain in response to ischemia/reperfusion injury
Crack, P. J., Taylor, J. M., Flentjar, N. J., de Haan, J. B., Hertzog, P. J., Iannello, R. C., & Kola, I. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00535.x · Cited by 212 · see citing works
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Jialal, I., & Devaraj, S. (2003) · Circulation · doi:10.1161/01.cir.0000048966.26216.4c · Cited by 208 · see citing works
Vitamin C and risk of coronary heart disease in women
Osganian, S. K., Stampfer, M. J., Rimm, E. B., Spiegelman, D. L., Hu, F. B., Manson, J. E., & Willett, W. C. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00575-8 · Cited by 205 · see citing works
Oxidative Stress in the Context of Acute Cerebrovascular Stroke
Kossi, M. M. H. E., & Zakhary, M. M. (2000) · Stroke · doi:10.1161/01.str.31.8.1889 · Cited by 185 · see citing works
Superoxide Generation in Directional Coronary Atherectomy Specimens of Patients With Angina Pectoris
Azumi, H., Inoue, N., Ohashi, Y., Terashima, M., Mori, T., Fujita, H., Awano, K., Kobayashi, K., Maeda, K., Hata, K., et al. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000037101.40667.62 · Cited by 180 · see citing works
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Mertens, A. C., Verhamme, P. B., Bielicki, J. K., Phillips, M. C., Quarck, R. A., Verreth, W., Stengel, D., Ninio, E., Navab, M., Mackness, B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000056523.08033.9f · Cited by 172 · see citing works
Extracellular production of singlet oxygen by stimulated macrophages quantified using 9,10-diphenylanthracene and perylene in a polystyrene film
Steinbeck, M. J., Khan, A. U., & Karnovsky, M. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82305-5 · Cited by 158 · see citing works
International Mortality from Heart Disease: Rates and Trends
Thom, T. J. (1989) · International Journal of Epidemiology · doi:10.1093/ije/18.supplement_1.s20 · Cited by 148 · see citing works
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Jacobson, G. M., Dourron, H. M., Liu, J., Carretero, O. A., Reddy, D. J., Andrzejewski, T., & Pagano, P. J. (2003) · Circulation Research · doi:10.1161/01.res.0000063423.94645.8a · Cited by 144 · see citing works
Increased NAD(P)H Oxidase and Reactive Oxygen Species in Coronary Arteries After Balloon Injury
Shi, Y., Niculescu, R., Wang, D., Patel, S., Davenpeck, K. L., & Zalewski, A. A. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.5.739 · Cited by 139 · see citing works
Prospects for Cardiovascular Research
Lefkowitz, R. J. (2001) · JAMA · doi:10.1001/jama.285.5.581 · Cited by 136 · see citing works
The Oxidized Lipid and Lipoxygenase Product 12(S)-Hydroxyeicosatetraenoic Acid Induces Hypertrophy and Fibronectin Transcription in Vascular Smooth Muscle Cells via p38 MAPK and cAMP Response Element-binding Protein Activation
Reddy, M. A., Thimmalapura, P., Lanting, L. L., Nadler, J. L., Fatima, S., & Natarajan, R. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111305200 · Cited by 135 · see citing works
Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch
Gregg, D., Rauscher, F. M., & Goldschmidt‐Clermont, P. J. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2003 · Cited by 129 · see citing works
Modulation of left ventricular relaxation in isolated ejecting heart by endogenous nitric oxide
Grocott-Mason, R. M., Anning, P. B., Evans, H. B., LEWIS, M. J., & Shah, A. M. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.5.h1804 · Cited by 129 · see citing works
Protein oxidation, tyrosine nitration, and inactivation of sarcoplasmic reticulum Ca2+‐ATPase in low‐frequency stimulated rabbit muscle
Klebl, B., Ayoub, A. T., & Pette, D. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00053-2 · Cited by 128 · see citing works
Induction of P-Selectin by Oxidized Lipoproteins
Vora, D. K., Fang, Z.-T., Liva, S. M., Tyner, T. R., Parhami, F., Watson, A. D., Drake, T. A., Territo, M., & Berliner, J. A. (1997) · Circulation Research · doi:10.1161/01.res.80.6.810 · Cited by 128 · see citing works
Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia
Imai, H., Graham, D. I., Masayasu, H., & Macrae, I. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01180-2 · Cited by 112 · see citing works
Cytochromeb558–Dependent NAD(P)H Oxidase–Phox Units in Smooth Muscle and Macrophages of Atherosclerotic Lesions
Kalinina, N., Agrotis, A., Tararak, E. M., Antropova, Y., Kanellakis, P., Ilyinskaya, O. P., Quinn, M. T., Smirnov, V. N., & Bobik, A. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000040222.02255.0f · Cited by 103 · see citing works
Inhalation of sidestream cigarette smoke accelerates development of arteriosclerotic plaques.
Penn, A. L., & Snyder, C. A. (1993) · Circulation · doi:10.1161/01.cir.88.4.1820 · Cited by 101 · see citing works
Increased Levels of 12(S)-HETE in Patients With Essential Hypertension
González-Núñez, D., Clària, J., Rivera, F., & Poch, E. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.334 · Cited by 98 · see citing works
The cytosolic antioxidant, copper/zinc superoxide dismutase, attenuates blood–brain barrier disruption and oxidative cellular injury after photothrombotic cortical ischemia in mice
Kim, G. W., Lewén, A., Copin, J. C., Watson, B. D., & Chan, P. H. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00237-8 · Cited by 96 · see citing works
Changes in oxidative stress, iNOS activity and neutrophil infiltration in severe transient focal cerebral ischemia in rats
Lerouet, D., Beray‐Berthat, V., Palmier, B., Plotkine, M., & Margaill, I. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03685-5 · Cited by 92 · see citing works
Target cell–derived superoxide anions cause efficiency and selectivity of intercellular induction of apoptosis
Herdener, M., Heigold, S., Sarán, M., & Bauer, G. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00422-6 · Cited by 89 · see citing works
Attenuated Neurotransmitter Release and Spreading Depression-Like Depolarizations after Focal Ischemia in Mutant Mice with Disrupted Type I Nitric Oxide Synthase Gene
Shimizu‐Sasamata, M., Bosque-Hamilton, P., Huang, P. L., Moskowitz, M., & Lo, E. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09564.1998 · Cited by 79 · see citing works
The Molecular Basis of Hypertension
Garbers, D. L., & Dubois, S. K. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.127 · Cited by 79 · see citing works
Inhibition of lipoxygenase pathway reduces blood pressure in renovascular hypertensive rats
Nozawa, K., Tuck, M. L., Golub, M. S., Eggena, P., Nadler, J. L., & Stern, N. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.6.h1774 · Cited by 73 · see citing works
NIDDM is associated with lower wall shear stress of the common carotid artery.
Irace, C., Carallo, C., Crescenzo, A., Motti, C., Franceschi, M. S. D., Mattioli, P. L., & Gnasso, A. (1999) · Diabetes · doi:10.2337/diabetes.48.1.193 · Cited by 70 · see citing works
Ribozyme-Mediated Inhibition of Rat Leukocyte-Type 12-Lipoxygenase Prevents Intimal Hyperplasia in Balloon-Injured Rat Carotid Arteries
Gu, J., Pei, H., Thomas, L. S., Nadler, J. L., Rossi, J. J., Lanting, L. L., & Natarajan, R. D. (2001) · Circulation · doi:10.1161/01.cir.103.10.1446 · Cited by 65 · see citing works
International Mortality from Heart Disease: Rates and Trends
Thom, T. J. (1989) · International Journal of Epidemiology · doi:10.1093/ije/18.3_supplement_1.s20 · Cited by 61 · see citing works
Enhanced TNFα and oxidative stress in patients with heart failure: effect of TNFα on platelet O2 - production
Biase, L. D., Pignatelli, P., Lenti, L., Tocci, G., Piccioni, F., Riondino, S., Pulcinelli, F. M., Rubattu, S., Volpe, M., & Violi, F. (2003) · Thrombosis and Haemostasis · doi:10.1160/th03-02-0105 · Cited by 59 · see citing works
Phenotype modulation in cultures of vascular smooth muscle cells from diabetic rats: Association with increased nitric oxide synthase expression and superoxide anion generation
Pandolfi, A., Grilli, A., Cilli, C., Patruno, A., Giaccari, A., Silvestre, S. D., Lutiis, M. A. D., Pellegrini, G., Capani, F., Consoli, A., et al. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10325 · Cited by 55 · see citing works
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Channon, K. M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000042203.08210.17 · Cited by 49 · see citing works
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Reddy, M. A., Kim, Y., Lanting, L. L., & Natarajan, R. D. (2003) · Hypertension · doi:10.1161/01.hyp.0000069011.18333.08 · Cited by 49 · see citing works
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Patterson, C., Madamanchi, N. R., & Runge, M. S. (2000) · Circulation Research · doi:10.1161/01.res.87.12.1074 · Cited by 41 · see citing works
Self-citation
Proliferative responses of quail aortic smooth muscle cells to benzo[a]pyrene: implications in PAH-induced atherogenesis
Ou, X., & Ramos, K. S. (1992) · Toxicology · doi:10.1016/0300-483x(92)90143-3 · Cited by 36 · see citing works
The Induction of Proliferative Vascular Smooth Muscle Cell Phenotypes by Benzo(a)pyrene Is Characterized by Up-Regulation of Inositol Phospholipid Metabolism and c-Ha-ras Gene Expression
Ramos, K. S., Zhang, Y., Sadhu, D. N., & Chapkin, R. S. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0335 · Cited by 36 · see citing works
Arachidonic acid increases activation of NADPH oxidase in monocytic U937 cells by accelerated translocation of p47-phox and co-stimulation of protein kinase C
Sellmayer, A., Obermeier, H., Danesch, U., Aepfelbacher, M., & Weber, P. C. (1996) · Cellular Signalling · doi:10.1016/0898-6568(96)00077-0 · Cited by 35 · see citing works
Measurement of oxidative stress in stroke-prone spontaneously hypertensive rat brain usingin vivoelectron spin resonance spectroscopy
Miyazaki, H., Shoji, H., & Lee, M. (2002) · Redox Report · doi:10.1179/135100002125000758 · Cited by 30 · see citing works
To C or not to C, that is the question!**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Frei, B. B. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00574-6 · Cited by 29 · see citing works
LIPOXYGENASE-DEPENDENT MECHANISMS IN HYPERTENSION
DelliPizzi, A., Guan, H., Tong, X., Takizawa, H., & Nasjletti, A. (2000) · Clinical and Experimental Hypertension · doi:10.1081/ceh-100100071 · Cited by 22 · see citing works
Changes in phagocyte activity in patients with ischaemic stroke
Alexandrova, M. L., Bochev, P. G., Markova, V. I., Bechev, B. G., Попова, М. А., Danovska, M., & Simeonova, V. K. (2001) · Luminescence · doi:10.1002/bio.667 · Cited by 11 · see citing works
A Peculiar Result and a Fanciful Hypothesis Regarding l -Arginine
Cooke, J. P., & Sydow, K. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000075300.76279.bb · Cited by 4 · see citing works

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Research works printed but not linked: 2

Fridovich I. The biology of oxygen radicals. Science. 1978;201: 875-880.
Patterson C, Ruef J, Madamanchi NR, Barry-Lane P, Hu Z, Horaist C, Ballinger CA, Brasier AR, Bode C, Runge MS. Stimulation of vascular cell NAD(P)H oxidase by thrombin; evidence that p47phox may par- ticipate in forming this oxidase in vitro and in vivo. J Biol Chem. 1999;274:19814 -19822.

Sorted by citations

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Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis
Kaneto, H., Katakami, N., Matsuhisa, M., & Matsuoka, T. (2010) · Mediators of Inflammation · doi:10.1155/2010/453892 · Cited by 578 · see citing works
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Direct Evidence of Endothelial Oxidative Stress With Aging in Humans
Donato, A. J., Eskurza, I., Silver, A., Levy, A., Pierce, G. L., Gates, P. E., & Seals, D. R. (2007) · Circulation Research · doi:10.1161/01.res.0000269183.13937.e8 · Cited by 558 · see citing works
Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications
Francque, S., van der Graaff, D., & Kwanten, W. J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.04.005 · Cited by 557 · see citing works
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
Regulation of NADPH Oxidases
Hordijk, P. L. (2006) · Circulation Research · doi:10.1161/01.res.0000204727.46710.5e · Cited by 525 · see citing works
Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis
Schrijvers, D. M., De Meyer, G. R. Y., Kockx, M. M., Herman, A. G., & Martinet, W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000166517.18801.a7 · Cited by 509 · see citing works
Oxidative stress and atherosclerosis
Singh, U. S., & Jialal, I. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.002 · Cited by 492 · see citing works
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside
Winnik, S. H., Auwerx, J. H., Sinclair, D. A., & Matter, C. M. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv290 · Cited by 443 · see citing works
Endothelial dysfunction : the early predictor of atherosclerosis
Mudau, M., Genis, A., Lochner, A., & Strijdom, H. (2012) · Cardiovascular Journal of Africa · doi:10.5830/cvja-2011-068 · Cited by 521 · see citing works
Cardiovascular Effects of Pulmonary Exposure to Single-Wall Carbon Nanotubes
Li, Z., Hulderman, T., Salmen, R., Chapman, R. S., Leonard, S. S., Young, S., Shvedova, A. A., Luster, M. I., & Simeonova, P. P. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9688 · Cited by 413 · see citing works
Diabetic Cardiovascular Disease Induced by Oxidative Stress
Kayama, Y., Raaz, U., Jagger, A. L., Adam, M., Schellinger, I. N., Sakamoto, M., Suzuki, H., Toyama, K., Spin, J. M., & Tsao, P. S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025234 · Cited by 408 · see citing works
Oxidative Stress in Diabetes: Implications for Vascular and Other Complications
Pitocco, D., Tesauro, M., Rizzi, A., Ghirlanda, G., & Cardillo, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141121525 · Cited by 409 · see citing works
The proteasomal system
Jung, T., Catalgol, B., & Grune, T. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.04.001 · Cited by 389 · see citing works
Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
van den Oever, I. A., Raterman, H. G., Nurmohamed, M. T., & Şimşek, S. (2010) · Mediators of Inflammation · doi:10.1155/2010/792393 · Cited by 365 · see citing works
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works
Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes
Tsimikas, S., Bergmark, C., Beyer, R. W., Patel, R., Pattison, J., Miller, E. R., Juliano, J., & Witztum, J. L. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02769-9 · Cited by 348 · see citing works
Oxidative Stress, Nitric Oxide, and Diabetes
Pitocco, D., Zaccardi, F., Stasio, E. D., Romitelli, F., Santini, S. A., Zuppi, C., & Ghirlanda, G. (2010) · The Review of Diabetic Studies · doi:10.1900/rds.2010.7.15 · Cited by 335 · see citing works
Review: reactive oxygen and nitrogen species and functional adaptation of the placenta
Myatt, L. (2010) · Placenta · doi:10.1016/j.placenta.2009.12.021 · Cited by 330 · see citing works
Oxidative stress and cardiovascular disease: Novel tools give (free) radical insight
Fearon, I. M., & Faux, S. P. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.05.013 · Cited by 330 · see citing works
Free radicals and senescence
Lu, T., & Finkel, T. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.01.011 · Cited by 327 · see citing works
Free Radicals, Mitochondria, and Oxidized Lipids
Gutiérrez, J., Ballinger, S. W., Darley-Usmar, V. M., & Landar, A. L. (2006) · Circulation Research · doi:10.1161/01.res.0000248212.86638.e9 · Cited by 319 · see citing works
Type 2 Diabetes Mellitus and Hypertension
Lastra, G., Syed, S., Kurukulasuriya, L. R., Manrique, C., & Sowers, J. R. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.005 · Cited by 307 · see citing works
Biochemical basis and metabolic interplay of redox regulation
Zhang, L., Wang, X., Cueto, R., Effi, C., Zhang, Y., Tan, H., Qin, X., Ji, Y., Yang, X., & Wang, H. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101284 · Cited by 308 · see citing works
Total Antioxidant Capacity: a biomarker in biomedical and nutritional studies
Kusano, C., & Ferrari, B. (2008) · Journal of cell & molecular biology · Cited by 304 · see citing works
Non-Invasive Vascular Function Tests:
Tomiyama, H., & Yamashina, A. (2009) · Circulation Journal · doi:10.1253/circj.cj-09-0534 · Cited by 298 · see citing works
Roles of Oxidative Stress and Inflammation in Vascular Endothelial Dysfunction-Related Disease
Higashi, Y. (2022) · Antioxidants · doi:10.3390/antiox11101958 · Cited by 317 · see citing works
Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function
Martins, A. R., Nachbar, R. T., Gorjão, R., Vinolo, M. A. R., Festuccia, W. T., Lambertucci, R. H., Cury‐Boaventura, M. F., Silveira, L. R., Curi, R., & Hirabara, S. M. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-30 · Cited by 288 · see citing works
Real-Time Discrimination and Versatile Profiling of Spontaneous Reactive Oxygen Species in Living Organisms with a Single Fluorescent Probe
Zhang, R., Zhao, J., Han, G., Liu, Z., Liu, C., Zhang, C., Liu, B., Jiang, C., Liu, R., Zhao, T., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.5b12848 · Cited by 287 · see citing works
Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans
Yu, E., Calvert, P. A., Mercer, J. R., Harrison, J. B., Baker, L. L., Figg, N. L., Kumar, S., Wang, J. C., Hurst, L. A., Obaid, D. R., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.002271 · Cited by 283 · see citing works
Combating oxidative stress disorders with citrus flavonoid: Naringenin
Zaidun, N. H., Thent, Z. C., & Latiff, A. A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.07.017 · Cited by 266 · see citing works
Involvement of Oxidative Stress in the Pathogenesis of Diabetes
Kaneto, H., Katakami, N., Kawamori, D., Miyatsuka, T., Sakamoto, K., Matsuoka, T., Matsuhisa, M., & Yamasaki, Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1465 · Cited by 264 · see citing works
Plasma membrane integrity: implications for health and disease
Ammendolia, D. A., Bement, W. M., & Brumell, J. H. (2021) · BMC Biology · doi:10.1186/s12915-021-00972-y · Cited by 267 · see citing works
Association between adherence to the Mediterranean diet and oxidative stress
Dai, J., Jones, D. P., Goldberg, J., Ziegler, T. R., Bostick, R. M., Wilson, P. W., Manatunga, A. K., Shallenberger, L., Jones, L., & Vaccarino, V. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26528 · Cited by 256 · see citing works
Nrf2 Protects Against Maladaptive Cardiac Responses to Hemodynamic Stress
Li, J., Ichikawa, T., Villacorta, L., Janicki, J. S., Brower, G. L., Yamamoto, M. P., & Cui, T. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.189480 · Cited by 254 · see citing works
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Zhao, Y., Xiong, W., Li, C., Zhao, R., Lu, H., Song, S., Zhou, Y., Hu, Y., Shi, B., & Ge, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01652-9 · Cited by 264 · see citing works
Oxidative Stress Signaling to Chromatin in Health and Disease
Kreuz, S., & Fischle, W. (2016) · Epigenomics · doi:10.2217/epi-2016-0002 · Cited by 254 · see citing works
Transcriptional responses to oxidative stress: Pathological and toxicological implications
Ma, Q. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.11.004 · Cited by 248 · see citing works
Raspberries and Human Health: A Review
Rao, A. V., & Snyder, D. M. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903484g · Cited by 250 · see citing works
Vascular Oxidative Stress: Impact and Therapeutic Approaches
Sena, C. M., Leandro, A., Azul, L., Seiça, R. M. F., & Perry, G. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01668 · Cited by 260 · see citing works
Radical medicine: treating ageing to cure disease
Finkel, T. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1763 · Cited by 234 · see citing works
Impact of oxidized low density lipoprotein on vascular cells
Galle, J., Hansen‐Hagge, T. E., Wanner, C., & Seibold, S. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.10.005 · Cited by 239 · see citing works
S -Nitrosylation: NO-Related Redox Signaling to Protect Against Oxidative Stress
Sun, J., Steenbergen, C., & Murphy, E. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1693 · Cited by 235 · see citing works
Reactive carbonyls and oxidative stress: Potential for therapeutic intervention
Ellis, E. M. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.03.015 · Cited by 237 · see citing works
Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry disease endothelial cells
Shen, J.-S., Meng, X., Moore, D. F., Quirk, J. M., Shayman, J. A., Schiffmann, R., & Kaneski, C. R. (2008) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2008.06.016 · Cited by 235 · see citing works
Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways
Raynes, R., Pomatto, L. C. D., & Davies, K. J. A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.05.001 · Cited by 229 · see citing works
Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress
LI, Y., Cao, Z., & Zhu, H. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2005.08.002 · Cited by 235 · see citing works
Metabolic stress, reactive oxygen species, and arrhythmia
Jeong, E.-M., Liu, M., Sturdy, M., Gao, G., Varghese, S. T., Sovari, A. A., & Dudley, S. C. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.09.018 · Cited by 234 · see citing works
Cyclic Stretch, Reactive Oxygen Species, and Vascular Remodeling
Birukov, K. G. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2390 · Cited by 224 · see citing works
Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high-performance liquid chromatography: Application to studies of oxidative stress
Nolin, T. D., McMenamin, M. E., & Himmelfarb, J. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.02.024 · Cited by 228 · see citing works
Involvement of MicroRNAs in Hydrogen Peroxide-mediated Gene Regulation and Cellular Injury Response in Vascular Smooth Muscle Cells*
Lin, Y., Liu, X., Cheng, Y., Yang, J., Huo, Y., & Zhang, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806920200 · Cited by 235 · see citing works
Redox signaling in cardiovascular health and disease
Madamanchi, N. R., & Runge, M. S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.001 · Cited by 223 · see citing works
Self-citation
ROS-Scavenging Therapeutic Hydrogels for Modulation of the Inflammatory Response
Kim, Y. E., & Kim, J. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c18261 · Cited by 229 · see citing works
The Renin Angiotensin Aldosterone System in Hypertension: Roles of Insulin Resistance and Oxidative Stress
Manrique, C. M., Lastra, G., Gardner, M., & Sowers, J. R. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.02.014 · Cited by 224 · see citing works
NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease
Vendrov, A. E., Vendrov, K. C., Smith, A., Yuan, J., Sumida, A., Robidoux, J., Runge, M. S., & Madamanchi, N. R. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6221 · Cited by 219 · see citing works
Self-citation
Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases
Taleb, A., Ahmad, K. A., Ihsan, A. U., Qu, J., Lin, N., Hezam, K., Koju, N., Hui, L., & Qi-long, D. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.03.140 · Cited by 217 · see citing works
Hypoxia inducible factor as a therapeutic target for atherosclerosis
Jain, T., Nikolopoulou, E. A., Xu, Q., & Qu, A. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.09.003 · Cited by 214 · see citing works
Oxidative Stress and Vascular Disease
Heistad, D. D. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000203525.62147.28 · Cited by 210 · see citing works
Vascular biology of hydrogen sulfide
Kanagy, N. L., Szabó, C., & Papapetropoulos, A. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00329.2016 · Cited by 209 · see citing works
Flavonoids: Antioxidants Against Atherosclerosis
Grassi, D., Desideri, G., & Ferri, C. (2010) · Nutrients · doi:10.3390/nu2080889 · Cited by 205 · see citing works
OxInflammation: From Subclinical Condition to Pathological Biomarker
Valacchi, G., Virgili, F., Cervellati, C., & Pecorelli, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00858 · Cited by 206 · see citing works
Teratogenic mechanisms of medical drugs
van Gelder, M. M. H. J., van Rooij, I. A. L. M., Miller, R. K., Zielhuis, G. A., den Berg, L. T. W. D. J.-V., & Roeleveld, N. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp052 · Cited by 205 · see citing works
Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases
Cepas, V., Collino, M., Mayo, J. C., & Sainz, R. M. (2020) · Antioxidants · doi:10.3390/antiox9020142 · Cited by 206 · see citing works
The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure
Zhou, S., Sun, W., Zhang, Z., & Zheng, Y. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/260429 · Cited by 203 · see citing works
Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers
Waring, W. S., McKnight, J. A., Webb, D. J., & Maxwell, S. R. J. (2006) · Diabetes · doi:10.2337/db06-0283 · Cited by 200 · see citing works
Oxidative Stress and Inflammation in Renal and Cardiovascular Complications of Diabetes
Charlton, A., Garzarella, J., Jandeleit-Dahm, K. A. M., & Jha, J. C. (2020) · Biology · doi:10.3390/biology10010018 · Cited by 207 · see citing works
Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells
Virgilio, A. L. D., Reigosa, M. A., Arnal, P., & de Mele, M. F. L. (2009) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2009.12.089 · Cited by 201 · see citing works
Endothelial dysfunction in rheumatic autoimmune diseases
Murdaca, G., Colombo, B. M., Cagnati, P., Gulli, R., Spanò, F. M., & Puppo, F. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.05.013 · Cited by 199 · see citing works
The role of oxidative stress in atherosclerosis.
Vogiatzi, G., Tousoulis, D., & Stefanadis, C. (2009) · PubMed · Cited by 198 · see citing works
Oxidative Stress and MicroRNAs in Vascular Diseases
Magenta, A., Greco, S., Gaetano, C., & Martelli, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917319 · Cited by 194 · see citing works
Neurovascular Dysfunction in Vascular Dementia, Alzheimer's and Atherosclerosis
Shabir, O., Berwick, J., & Francis, S. E. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0465-5 · Cited by 191 · see citing works
Overweight and Obese Humans Demonstrate Increased Vascular Endothelial NAD(P)H Oxidase-p47 phox Expression and Evidence of Endothelial Oxidative Stress
Silver, A., Beske, S. D., Christou, D. D., Donato, A. J., Moreau, K. L., Eskurza, I., Gates, P. E., & Seals, D. R. (2007) · Circulation · doi:10.1161/circulationaha.106.657486 · Cited by 190 · see citing works
Reactive oxygen species: influence on cerebral vascular tone
Faraci, F. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01044.2005 · Cited by 189 · see citing works
Oxidant mechanisms in childhood obesity: the link between inflammation and oxidative stress
Codoñer‐Franch, P., Valls‐Bellés, V., Arilla-Codoñer, Á., & Alonso‐Iglesias, E. (2011) · Translational research · doi:10.1016/j.trsl.2011.08.004 · Cited by 189 · see citing works
Recent Advances in Understanding Endothelial Dysfunction in Atherosclerosis
Yang, Z., & Ming, X. (2006) · Clinical Medicine & Research · doi:10.3121/cmr.4.1.53 · Cited by 189 · see citing works
3D‐Printing Strong High‐Resolution Antioxidant Bioresorbable Vascular Stents
van Lith, R., Baker, E., Ware, H. O. T., Yang, J. H., Farsheed, A. C., Sun, C., & Ameer, G. A. (2016) · Advanced Materials Technologies · doi:10.1002/admt.201600138 · Cited by 189 · see citing works
Mechanosensitive TRP channels in cardiovascular pathophysiology
Inoue, R., Zhong, J., & Kawarabayashi, Y. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.009 · Cited by 189 · see citing works
Extracts, Anthocyanins and Procyanidins from Aronia melanocarpa as Radical Scavengers and Enzyme Inhibitors
Bräunlich, M., Slimestad, R., Wangensteen, H., Brede, C., Malterud, K. E., & Barsett, H. (2013) · Nutrients · doi:10.3390/nu5030663 · Cited by 188 · see citing works
Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells
Sheng-kai, Y., Chang, T., Wang, H., Wu, L., Wang, R., & Meng, Q. H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.058 · Cited by 187 · see citing works
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
Sosnowska, B., Mazidi, M., Penson, P. E., Gluba-Brzózka, A., Rysz, J., & Banach, M. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.08.027 · Cited by 185 · see citing works
Oxidative stress in patients with cardiovascular disease and chronic renal failure
Popolo, A., Autore, G., Pinto, A., & Marzocco, S. (2013) · Free Radical Research · doi:10.3109/10715762.2013.779373 · Cited by 185 · see citing works
Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress
Bachar, A., Scheffer, L., Schroeder, A. S., Nakamura, H. K., Cobb, L. J., Oh, Y. K., Lerman, L. O., Pagano, R. E., Cohen, P., & Lerman, A. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq191 · Cited by 182 · see citing works

Oxidative stress and atherosclerosis
Singh, U. S., & Jialal, I. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.002 · Cited by 492 · see citing works
Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes
Madamanchi, N. R., Hakim, Z. S., & Runge, M. S. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.01085.x · Cited by 212 · see citing works
Self-citation
Oxidative stress and cardiovascular injury: Part II: animal and human studies
Griendling, K. K., Garret, P., & Fitzgerald, A. (2016)
Reactive Oxygen Species and Atherosclerosis
Víctor, V. M. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_53 · Cited by 1 · see citing works
Oxidative stress in cardiovascular diseases
Goswami, S., & Maulik, S. (2015) · Journal of the Practice of Cardiovascular Sciences · doi:10.4103/2395-5414.157555 · Cited by 3 · see citing works

Authors: Madamanchi, N. R., Vendrov, A., & Runge, M. S.
Affiliations: University of North Carolina at Chapel Hill (US)
ORCID: Madamanchi, Nageswara R.
Vendrov, Aleksandr
Runge, Marschall S.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-01
Volume: 25
Issue: 1
Pages: 29-38
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000150649.39934.13
OpenAlex: W2109698138
Cited by: 1,618
References: 135
Citations by year: 2026: 47 · 2025: 46 · 2024: 42 · 2023: 53 · 2022: 61 · 2021: 62 · 2020: 73 · 2019: 73 · 2018: 57 · 2017: 75 · 2016: 78 · 2015: 105 · 2014: 111 · 2013: 104 · 2012: 95
FWCI: 7.02
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oxidative stress, reactive oxygen species, atherosclerosis, vascular disease, cardiovascular disease, NADPH oxidase, xanthine oxidase, lipoxygenase, nitric oxide synthase uncoupling, vascular inflammation, atherogenesis, antioxidants, redox signaling, biomarkers, cardiovascular risk factors
MeSH terms: Animals, Humans, Vascular Diseases, Oxidative Stress

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