The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Protein Oxidation and Lipid Peroxidation in Brain of Subjects with Alzheimer's Disease: Insights into Mechanism of Neurodegeneration from Redox Proteomics
Abstract
Alzheimer's disease (AD), the leading cause of dementia, involves regionalized neuronal death, synaptic loss, and an accumulation of intraneuronal, neurofibrillary tangles and extracellular senile plaques. Although the initiating causes leading to AD are unknown, a number of previous studies reported the role of oxidative stress in AD brain. Postmortem analysis of AD brain showed elevated markers of oxidative stress including protein nitrotyrosine, carbonyls in proteins, lipid oxidation products, and oxidized DNA bases. In this review, we focus our attention on the role of protein oxidation and lipid peroxidation in the pathogenesis of AD. Particular attention is given to the current knowledge about the redox proteomics identification of oxidatively modified proteins in AD brain.
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Cited by
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Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
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Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans
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Metadata
- Authors
- Sultana, R., Perluigi, M., & Butterfield, D. A.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2006-11
- Volume
- 8
- Issue
- 11-12
- Pages
- 2021-2037
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W1978308357
- Cited by
- 262
- References
- 25
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sultana, R., Perluigi, M., & Butterfield, D. A. (2006). Protein Oxidation and Lipid Peroxidation in Brain of Subjects with Alzheimer's Disease: Insights into Mechanism of Neurodegeneration from Redox Proteomics. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2006.8.2021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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