The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hydrogen Sulfide Protects HT22 Neuronal Cells from Oxidative Stress
Abstract
Hydrogen sulfide (H2S) is a neuromodulator in the brain and a relaxant for smooth muscle. H2S protects primary cortical neurons from oxidative stress by increasing the intracellular concentrations of glutathione, the major antioxidant in cells. However, changes in glutathione alone are not sufficient to account for full protection in all types of nerve cells. H2S is here shown to protect an immortalized mouse hippocampal cell line from oxidative glutamate toxicity by activating ATP-dependent K+ (KATP) and Cl- channels, in addition to increasing the levels of glutathione. The present study therefore identifies a novel pathway for H2S protection from oxidative stress.
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Citations
Cites
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762
Alzheimer Disease and Oxidative Stress
Perry, G., Cash, A. D., & Smith, M. A. (2002) · BioMed Research International · doi:10.1155/s1110724302203010 · Cited by 455
Cited by
Hydrogen sulphide and its therapeutic potential
Szabó, C. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2425 · Cited by 2,038
Hydrogen Sulfide and Cell Signaling
Li, L., Rose, P., & Moore, P. K. (2011) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100505 · Cited by 1,296
Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria
Kimura, Y., Goto, Y.-I., & Kimura, H. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2282 · Cited by 685
Self-citationSzabo, C., & Papapetropoulos, A. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014050 · Cited by 423
Chemical foundations of hydrogen sulfide biology
Li, Q., & Lancaster, J. R. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.001 · Cited by 334
Metadata
- Authors
- Kimura, Y., Dargusch, R., Schubert, D., & Kimura, H.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2006-03
- Volume
- 8
- Issue
- 3-4
- Pages
- 661-670
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2094983394
- Cited by
- 291
- References
- 3
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
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