Alzheimer Disease and Oxidative Stress

Copper, iron and zinc in Alzheimer's disease senile plaques

Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120 · see citing works

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

Smith, M. A., Harris, P. L. R., Sayre, L. M., & Perry, G. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9866 · Cited by 1,357 · see citing works

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296 · see citing works

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

Hensley, K., Carney, J. M., Mattson, M. P., Aksenova, M., Harris, M., Wu, J. F., Floyd, R. A., & Butterfield, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3270 · Cited by 1,086 · see citing works

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

Sayre, L., Zelasko, D. A., Harris, P. L. R., Perry, G., Salomon, R. G., & Smith, M. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052092.x · Cited by 1,032 · see citing works

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

Nunomura, A., Perry, G., Pappolla, M., Wade, R., Hirai, K., Chiba, S., & Smith, M. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01959.1999 · Cited by 768 · see citing works

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

Smith, M. A., Taneda, S., Richey, P. L., Miyata, S., Yan, S. D., Stern, D., Sayre, L. M., Monnier, V. M., & Perry, G. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5710 · Cited by 715 · see citing works

Radical AGEing in Alzheimer's disease

Smith, M. A., Sayre, L. M., Monnier, V. M., & Perry, G. L. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93897-7 · Cited by 462 · see citing works

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

Smith, M. A., Kutty, R. K., Richey, P. L., Yan, S. D., Stern, D., Chader, G. J., Wiggert, B. O., Petersen, R. B., & Perry, G. L. (1994) · PubMed Central · Cited by 425 · see citing works

Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease.

Friguet, B., Stadtman, E. R., & Szweda, L. I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31853-7 · Cited by 311 · see citing works

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

Münch, G. W., Schinzel, R., Loske, C., Wong, A. O., Durany, N., Li, J. J., Vlassara, H., Smith, M. A., Perry, G. L., & Riederer, P. F. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050069 · Cited by 302 · see citing works

Carbonyl‐Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's Disease

Smith, M. A., Rudnicka-Nawrot, M., Richey, P., Praprotnik, D., Mulvihill, P., Miller, C., Sayre, L., & Perry, G. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64062660.x · Cited by 240 · see citing works

Induction of Heme Oxygenase‐1 mRNA and Protein in Neocortex and Cerebral Vessels in Alzheimer's Disease

Premkumar, D. R., Smith, M. A., Richey, P. L., Petersen, R. B., Castellani, R. J., Kutty, R. K., Wiggert, B. O., Perry, G. L., & Kalaria, R. N. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031399.x · Cited by 211 · see citing works

In Alzheimer's Disease, Heme Oxygenase Is Coincident with Alz50, an Epitope of τ Induced by 4‐Hydroxy‐2‐Nonenal Modification

Takeda, A., Smith, M. A., Ávila, J., Nunomura, A., Siedlak, S. L., Zhu, X., Perry, G. L., & Sayre, L. M. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751234.x · Cited by 203 · see citing works

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

Montine, T. J., Amarnath, K., Martin, M. E., Strittmatter, W. J., & Graham, D. G. (1996) · Europe PMC (PubMed Central) · Cited by 136 · see citing works

Early Glycoxidation Damage in Brains from Down's Syndrome

Odetti, P. R., Angelini, G., Dapino, D., Zaccheo, D., Garibaldi, S., Dagna-Bricarelli, F., Piombo, G., Perry, G. L., Smith, M. A., Traverso, N., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8186 · Cited by 116 · see citing works

Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy.

Pérez, M., Valpuesta, J., de Garcini, E. M., Quintana, C., Arrasate, M., Carrascosa, J. L., Rábano, A., de Yébenes, J. G., & Ávila, J. (1998) · Europe PMC (PubMed Central) · Cited by 94 · see citing works

Advanced Maillard reaction end products are associated with Alzheimer disease pathology

(1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1794e · Cited by 33 · see citing works

Progressive Hyperphosphorylation of Neurofilament Heavy Subunits with Aging: Possible Involvement in the Mechanism of Neurofilament Accumulation

Gou, J. P., Eyer, J., & Leterrier, J. F. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2475 · Cited by 25 · see citing works

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484 · see citing works

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

Erickson, M. A., & Banks, W. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.135 · Cited by 572 · see citing works

Microglial cell dysregulation in brain aging and neurodegeneration

von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works

Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

Butterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564 · see citing works

Intracellular iron transport and storage: from molecular mechanisms to health implications

Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526 · see citing works

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

Nixon, R. A., & Rubinsztein, D. C. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00757-5 · Cited by 435 · see citing works

Therapeutic potential of mood stabilizers lithium and valproic acid:Beyond bipolar disorder

Chiu, C.-T., Wang, Z., Hunsberger, J. G., & Chuang, D.-M. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005512 · Cited by 404 · see citing works

Ozone, Particulate Matter, and Newly Diagnosed Alzheimer's Disease: A Population-Based Cohort Study in Taiwan

Jung, C.-R., Lin, Y.-T., & Hwang, B.-F. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-140855 · Cited by 380 · see citing works

Mitochondrial Dysfunction, Oxidative Stress, Neuroinflammation, and Metabolic Alterations in the Progression of Alzheimer's Disease: A Meta-Analysis of In Vivo Magnetic Resonance Spectroscopy Studies

Song, T., Song, X., Zhu, C., Patrick, R., Skurla, M., Santangelo, I., Green, M., Harper, D., Ren, B., Forester, B. P., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101503 · Cited by 346 · see citing works

Alzheimer’s disease-related alterations in synaptic density: neocortex and hippocampus.

Scheff, S. W., & Price, D. A. (2006) · Journal of Alzheimer's Disease · doi:10.3233/jad-2006-9s312 · Cited by 284 · see citing works

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes

Valles, S. L., Dolz-Gaiton, P., Gambini, J., Borras, C., LLoret, A., Pallardo, F. V., & Viña, J. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.044 · Cited by 186 · see citing works

MRI and histological analysis of beta-amyloid plaques in both human Alzheimer’s disease and APP/PS1 transgenic mice.

Meadowcroft, M. D., Connor, J. R., Smith, M. B., & Yang, Q. X. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21731 · Cited by 176 · see citing works

Implications of Glycosylation in Alzheimer’s Disease

Haukedal, H., & Freude, K. K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.625348 · Cited by 114 · see citing works

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

Di Domenico, F., Tramutola, A., Foppoli, C., Head, E., Perluigi, M., & Butterfield, D. A. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.009 · Cited by 89 · see citing works

Antiamnesic Effects of <i>Desmodium gangeticum</i> in Mice

JOSHI, H., & PARLE, M. (2006) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.126.795 · Cited by 70 · see citing works

Enhancement of β-secretase inhibition and antioxidant activities of<i>tempeh</i>, a fermented soybean cake through enrichment of bioactive aglycones

Ahmad, A., Ramasamy, K., Majeed, A. B. A., & Mani, V. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2014.942791 · Cited by 60 · see citing works

Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease

Adalier, N., & Parker, H. (2016) · Antioxidants · doi:10.3390/antiox5040040 · Cited by 40 · see citing works

Influential role of 7-Ketocholesterol in the progression of Alzheimer’s disease

Mahalakshmi, K., Parimalanandhini, D., Sangeetha, R., Livya Catherene, M., Beulaja, M., Thiagarajan, R., Arumugam, M., Janarthanan, S., & Manikandan, R. (2021) · Prostaglandins &amp; Other Lipid Mediators · doi:10.1016/j.prostaglandins.2021.106582 · Cited by 32 · see citing works

Memory Enhancing Activity of Abana®: An Indian Ayurvedic Poly-Herbal Formulation

Parle, M., & Vasudevan, M. (2007) · Journal of Health Science · doi:10.1248/jhs.53.43 · Cited by 31 · see citing works

<i>In Vitro</i> and <i>In Vivo</i> Anti‐AChE and Antioxidative Effects of <i>Schisandra chinensis</i> Extract: A Potential Candidate for Alzheimer’s Disease

Song, X., Wang, T., Guo, L., Jin, Y., Wang, J., Yin, G., Jiang, K., Wang, L., Huang, H., & Zeng, L. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/2804849 · Cited by 8 · see citing works

Apolipoprotein E Interaction with the Neurofibrillary Tangles and Senile Plaques in Alzheimer Disease: Implications for Disease Pathogenesis

Richey, P. L., Siedlak, S. L., Smith, M. A., & Perry, G. L. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1389 · Cited by 72 · see citing works

[Alzheimer's disease: cellular and molecular aspects].

Octave, J., & Pierrot, N. (2008) · PubMed · Cited by 8 · see citing works

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.

Dickson, D. W., Farlo, J., Davies, P., Crystal, H., Fuld, P. A., & Yen, S. H. (1988) · PubMed Central · Cited by 383 · see citing works

Fibrous astrocytes in Alzheimer's disease and senile dementia of Alzheimer's type

Mancardi, G., Liwnicz, B. H., & Mandybur, T. I. (1983) · Acta Neuropathologica · doi:10.1007/bf00688390 · Cited by 88 · see citing works

Tau protein immunoreactivity in dementia of the Alzheimer type. I. Morphology, evolution, distribution, and pathogenetic implications.

Papasozomenos, S. C. (1989) · PubMed · Cited by 81 · see citing works