The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Free and Acid-Labile Hydrogen Sulfide Concentrations in Mouse Tissues: Anomalously High Free Hydrogen Sulfide in Aortic Tissue
Abstract
Endogenously produced hydrogen sulfide is thought to function as an intracellular messenger. There is, however, little information on tissue concentrations of free hydrogen sulfide, the putative messenger form of this molecule, versus that of the bound (acid-labile) form. The present report describes the application of a novel technique to measure free and acid-labile hydrogen sulfide in mouse tissues. Very low free hydrogen sulfide concentrations (<0.050 μmol/kg) were observed in brain, liver, blood, heart, kidney, striated muscle, and esophagus. Aortic concentrations of free hydrogen sulfide were 20 to 100 times greater than that of the other tissues. Acid-labile hydrogen sulfide concentrations were multiple orders of magnitude greater than that of the free form in every tissue other than aorta. Previous reports of tissue hydrogen sulfide concentrations of 30 to >100 μmol/kg measured bound rather than free hydrogen sulfide, the observation that aorta contains anomalously high free hydrogen sulfide concentrations lends support for a vasodilator function for this molecule, and the very low free hydrogen sulfide concentrations in most tissues seemingly requires intermediation of a yet to be described receptor-like mechanism if this molecule is to serve as a gasotransmitter.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As with nitrite [78], sulfide concentrations in rodents are higher in tissues than in blood, and the highest concentrations are observed in the vasculature [79], rendering the aorta a relevant target for the interaction of nitrite with sulfide.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [79]
Citations
Cites
H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., et al. (2008) · Science · doi:10.1126/science.1162667 · Cited by 2,310
The possible role of hydrogen sulfide as an endogenous neuromodulator
Abe, K., & Kimura, H. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01066.1996 · Cited by 2,240
Stipanuk, M. H., & Beck, P. W. (1982) · Biochemical Journal · doi:10.1042/bj2060267 · Cited by 710
Furne, J. K., Saeed, A., & Levitt, M. D. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90566.2008 · Cited by 628
Singh, S., Padovani, D., Leslie, R. A., Chiku, T., & Banerjee, R. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.010868 · Cited by 615
A Source of Hydrogen Sulfide and a Mechanism of Its Release in the Brain
Ishigami, M., Hiraki-Kamon, K., Umemura, K., Ogasawara, Y., Ishii, K., & Kimura, H. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2132 · Cited by 478
Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors
Nelson, M. E., Kuryatov, A., Choi, C. H., Zhou, Y., & Lindstrom, J. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.332 · Cited by 422
Dorman, D. C. (2002) · Toxicological Sciences · doi:10.1093/toxsci/65.1.18 · Cited by 362
Goodwin, L. R., Francom, D. M., Dieken, F. P., Taylor, J. D., Warenycia, M. W., Reiffenstein, R. J., & Dowling, G. (1989) · Journal of Analytical Toxicology · doi:10.1093/jat/13.2.105 · Cited by 323
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats
Wallace, J. L., Vong, L., McKnight, W., Dicay, M., & Martin, G. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.012 · Cited by 308
Flagged first, then by citations
Research works printed but not linked: 1
- 3. Cotton FA and Wilkinson G. Advanced Inorganic Chemistry , 5th edition. New York: Wiley, 1988, p. 1455.
Cited by
Sorted by citations
Items 101–176 of 176
Landry, A. P., Moon, S., Bonanata, J. N., Cho, U., Coitiño, E. L., & Banerjee, R. V. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c06066 · Cited by 27
Modulation of H 2 S Metabolism by Statins: A New Aspect of Cardiovascular Pharmacology
Bełtowski, J., & Jamróz-Wiśniewska, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4358 · Cited by 27
Mys, L. A., Strutynska, N. A., Goshovska, Y. V., & Sagach, V. F. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0411 · Cited by 26
Myszkowska, J., Dereven’kov, I. А., Makarov, S. V., Spiekerkoetter, U., & Hannibal, L. (2021) · Antioxidants · doi:10.3390/antiox10071065 · Cited by 26
From Gasotransmitter to Immunomodulator: The Emerging Role of Hydrogen Sulfide in Macrophage Biology
Cornwell, A., & Badiei, A. (2023) · Antioxidants · doi:10.3390/antiox12040935 · Cited by 27
Zhu, Z., Lian, X., & Bhatia, M. (2022) · Antioxidants · doi:10.3390/antiox11112162 · Cited by 25
Age-Dependent Allergic Asthma Development and Cystathionine Gamma-Lyase Deficiency
Wang, P., Wu, L., Ju, Y., Fu, M., Shuang, T., Qian, Z., & Wang, R. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6875 · Cited by 24
Biological Effects of Hydrogen Sulfide and Its Protective Role in Intracerebral Hemorrhage
Zhang, J., Shan, H., Tao, L., & Zhang, M. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01608-6 · Cited by 24
Li, P., Liu, H., Shi, X., & Prokosch, V. (2021) · Molecules · doi:10.3390/molecules26092411 · Cited by 25
Wang, M., Guo, Z., & Wang, S. (2013) · Gene Expression · doi:10.3727/105221613x13571653093286 · Cited by 22
Hypoxia-induced arterial chemoreceptor stimulation and Hydrogen sulfide: Too much or too little?
Haouzi, P. A., Bell, H. J., & de Louw, A. V. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.09.009 · Cited by 21
Ngo, J. P., Ow, C. P. C., Gardiner, B. S., Kar, S., Pearson, J. T., Smith, D. W., & Evans, R. G. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00246.2016 · Cited by 21
Inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide
Nalli, A. D., Wang, H., Bhattacharya, S., Blakeney, B. A., & Murthy, K. S. (2017) · Pharmacology Research & Perspectives · doi:10.1002/prp2.343 · Cited by 21
Gas regulation of complex II reversal via electron shunting to fumarate in the mammalian ETC
Banerjee, R. V., & Kumar, R. (2022) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2022.03.011 · Cited by 19
Roda, B., Zhang, N., Gambari, L., Grigolo, B., Eller-Vainicher, C., Gennari, L., Zappi, A., Giordani, S., Marassi, V., Zattoni, A., et al. (2022) · Antioxidants · doi:10.3390/antiox11050939 · Cited by 19
Hydrogen sulfide depolarizes neurons in the nucleus of the solitary tract of the rat
Malik, R., & Ferguson, A. V. (2015) · Brain Research · doi:10.1016/j.brainres.2015.12.029 · Cited by 18
Mir, J. M., & MAURYA, R. C. (2018) · Journal of the Chinese Advanced Materials Society · doi:10.1080/22243682.2018.1493951 · Cited by 18
Wang, M., Guo, Z., & Wang, S. (2013) · Biochemical Genetics · doi:10.1007/s10528-013-9581-1 · Cited by 17
Ji, Y., Li, Y., Zhao, Z., Li, P., & Xie, Y. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.582851 · Cited by 16
H 2 S preconditioning induces long-lived perturbations in O 2 metabolism
Hanna, D. A., Diessl, J., Guha, A., Kumar, R., Andren, A. C., Lyssiotis, C. A., & Banerjee, R. V. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2319473121 · Cited by 16
Sonobe, T., & Haouzi, P. A. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00464.2016 · Cited by 15
Methylene Blue Counteracts H2S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction
Cheung, J. Y., Wang, J., Zhang, X.-Q., Song, J., Davidyock, J. M., Jaña, F., Shanmughapriya, S., Worth, A. M., Madesh, M., Judenherc‐Haouzi, A., et al. (2018) · Cardiovascular Toxicology · doi:10.1007/s12012-018-9451-5 · Cited by 16
Zhu, J., Ligi, S., & Yang, G. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108920 · Cited by 14
Berenyiová, A., Golas, S., Drobna, M., Cebová, M., & Čačányiová, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094749 · Cited by 15
Scrivner, O., Kumar, M. R., Sorokolet, K., Wong, A., Kebaara, B. W., & Farmer, P. J. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00257 · Cited by 13
Haouzi, P. A. (2016) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2016.03.015 · Cited by 13
Biswal, P., Sahu, M. R., Ahmad, M. H., & Mondal, A. C. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101885 · Cited by 12
Fan, J., Pung, E., Lin, Y., & Wang, Q. (2022) · PubMed Central · doi:10.12336/biomatertransl.2022.04.005 · Cited by 12
Mali, S. M., Narwade, S. S., Mulik, B. B., Sapner, V. S., Annadate, S. J., & Sathe, B. R. (2023) · Electrocatalysis · doi:10.1007/s12678-023-00839-6 · Cited by 12
Reprint of: Hydrogen sulfide in stroke: Protective or deleterious?
Chan, S. J., & Wong, P. T. ‐. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2016.11.016 · Cited by 12
The Chemistry and Metabolism of Arsenic
Thomas, D. J. (2015) · Wiley eBooks · doi:10.1002/9781118876992.ch4 · Cited by 12
Detection of hydrogen sulfide in biological samples: current and future
Kolluru, G. K., Shen, X., & Kevil, C. G. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.10.132 · Cited by 11
A growth chamber for chronic exposure of mammalian cells to H2S
Hanna, D. A., Vitvitsky, V., & Banerjee, R. V. (2023) · Analytical Biochemistry · doi:10.1016/j.ab.2023.115191 · Cited by 9
Feng, H., Sun, Z., Han, B., Xia, H., Chen, L., Tian, C., Yan, S., Shi, Y., Yin, J., Song, W., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07167-7 · Cited by 10
Jeddi, S., Gholami, H., Gheibi, S., Kashfi, K., & Ghasemi, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28426 · Cited by 10
Hydrogen Sulfide Actions in the Vasculature
Mendiola, P. J., Naik, J. S., Bosc, L. V. G., Gardiner, A. S., Birg, A., & Kanagy, N. L. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200036 · Cited by 10
Pose, M., Dillon, K. M., Denicola, A., Álvarez, B., Matson, J. B., Möller, M. N., & Cuevasanta, E. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102402 · Cited by 9
Santos, C. I. M., Santiago, A. M., Araújo, A. R. L., Pinto, S. N., Agostinho, R. R., Simão, S., Pais-de-Azevedo, T., Antunes, C., Faustino, M. A. F., Araújo, I. M., et al. (2023) · Dyes and Pigments · doi:10.1016/j.dyepig.2023.111304 · Cited by 9
Singh, M., Devadoss, D., Manevski, M., Sheybani, A., Ivanciuc, T., Exil, V. J., Agarwal, H. S., Raizada, V., Garofalo, R. P., Chand, H. S., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01628 · Cited by 10
The Role of Hydrogen Sulfide in the Regulation of the Pulmonary Vasculature in Health and Disease
Aaronson, P. I. (2025) · Antioxidants · doi:10.3390/antiox14030341 · Cited by 8
Enzymology of Hydrogen Sulfide Turnover
Motl, N., Yadav, P. K., & Banerjee, R. V. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1550-3_1 · Cited by 6
Power and poison: The intersections of H2S and O2 metabolism
Brake, J., & Banerjee, R. V. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110810 · Cited by 6
Gan, L., Peng, C., Wu, J., Li, Q., Pan, J., Ding, Y., Gao, X.-F., & Chen, L. (2024) · International Heart Journal · doi:10.1536/ihj.23-370 · Cited by 5
Yan, Y., Li, S., Jiang, L., Peng, R., Li, J., Cui, X., Zhang, M., Deng, D., Wang, G., & Geng, X. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.136868 · Cited by 5
The role of hydrogen sulfide in the retina
Cornwell, A., & Badiei, A. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109568 · Cited by 5
Shi, W., Zhang, R., Wu, X., Yu, Q., & Xiao, Y. (2025) · Journal of Chromatography Open · doi:10.1016/j.jcoa.2025.100216 · Cited by 5
Tan, J., Lü, Z., Gao, C., Zhang, Z., Sun, Z., Ling, B., Li, Z., & You, J. (2023) · Dyes and Pigments · doi:10.1016/j.dyepig.2023.111199 · Cited by 4
Hydrogen Sulfide: A New Tool to Design and Develop Drugs
Muniraj, N., Ang, A. D., Badiei, A., Rivers‐Auty, J., & Bhatia, M. (2014) · Clinical Anti-Inflammatory & Anti-Allergy Drugs · doi:10.2174/2212703801666140311005131 · Cited by 4
Xu, S., Deng, X., Ji, S., Chen, L., Zhao, T., Luo, F., Qiu, B., Lin, Z., & Guo, L. (2022) · The Analyst · doi:10.1039/d2an00149g · Cited by 4
Zhao, M., Liu, J., Wang, Y., Song, Y., Fu, Q., Zhang, C., Li, X., Ling, Z., Ma, Y., & Liu, Y. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.110625 · Cited by 4
Hydrogen Sulfide-Mediated Cellular Signaling and Cytoprotection
Kimura, H. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1550-3_9 · Cited by 4
Scrivner, O., Ismaeel, A., Kumar, M. R., Sorokolet, K., Koutakis, P., & Farmer, P. J. (2021) · Molecules · doi:10.3390/molecules26237160 · Cited by 3
Effect of exogenous hydrogen sulfide in the nucleus tractus solitarius on gastric motility in rats
Sun, H., Li, C., Shi, Y., Li, J., Wang, Y., Han, L.-N., Zhu, L.-J., & Zhang, Y. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i29.4557 · Cited by 3
Lab‐on‐a‐Chip for hydrogen sulphide detection—Part II: Integrated with screen‐printed electrode
Baniya, A., Thapa, S., Borquist, E., Bailey, D., Wood, D., Kevil, C. G., Arumugam, P. U., & Weiss, L. (2019) · Medical Devices & Sensors · doi:10.1002/mds3.10053 · Cited by 3
Development and application of LC-MS/MS method for the quantification of hydrogen sulfide in the eye
Okolie, A., Nigro, M. R., Polk, S., Stubbs, K., Selvam, C., Ohia, S. E., Liang, D., & Mbye, Y. F. N. (2023) · Analytical Biochemistry · doi:10.1016/j.ab.2023.115448 · Cited by 3
Hydrogen Sulfide Actions in the Vasculature
Mendiola, P. J., Naik, J. S., Bosc, L. V. G., Gardiner, A. S., Birg, A., & Kanagy, N. L. (2021) · Comprehensive physiology · doi:10.1002/j.2040-4603.2021.tb00187.x · Cited by 3
Physiological and Pathophysiological Functions of Hydrogen Sulfide
Kimura, H. (2012) · Springer eBooks · doi:10.1007/978-3-642-30338-8_3 · Cited by 2
Calligaris, M., Aleksova, A., Fluca, A. L., Janjusevic, M., Carpi, G., Stefanizzi, D., Carnevali, S., Curcio, F., Puca, A. A., Cattaneo, M., et al. (2025) · Vascular Pharmacology · doi:10.1016/j.vph.2025.107470 · Cited by 2
When Carbon Monoxide Meets Hydrogen Sulfide
Wang, R. (2022) · Wiley eBooks · doi:10.1002/9781119783435.ch9 · Cited by 2
A biocompatible fluorescent probe for endogenous hydrogen sulfide detection and imaging
Zhu, X., Chen, H., & Ke, F. (2024) · Analytical Biochemistry · doi:10.1016/j.ab.2024.115718 · Cited by 1
Kelava, L., Pákai, E., Ogasawara, K., Fekete, K., Pozsgai, G., Pintér, E., & Garami, A. (2024) · Biomedicines · doi:10.3390/biomedicines12122874 · Cited by 1
Lab‐on‐a‐chip for hydrogen sulphide detection—Part I: Sulphide separation from plasma sample
Baniya, A., Thapa, S., Borquist, E., Bailey, D., Wood, D., Glawe, J. D., Kevil, C. G., & Weiss, L. (2019) · Medical Devices & Sensors · doi:10.1002/mds3.10045 · Cited by 1
Nanostructured Ce/CeO2-rGO: Highly Sensitive and Selective Electrochemical Hydrogen Sulphide SensorPreprint
Mali, S. M., Narwade, S. S., Mulik, B. B., Sapner, V. S., Annadate, S. J., & Sathe, B. R. (2023) · Research Square · doi:10.21203/rs.3.rs-2707776/v1 · Cited by 1
Perna, A. F., & Ingrosso, D. (2012) · doi:10.1002/9781118424032.ch8
Hydrogen Sulfide: Physiological and Pathophysiological Functions
Liu, Y. T., & Bian, J. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1550-3_6
Peter, E. A., Varma, J., & Kevil, C. G. (2015) · Atherosclerosis · doi:10.1002/9781118828533.ch31
The roles of H2S on hepatic acetyl-CoA and lipid metabolism
Ali, A. (2020) · Lu Zone Ul (Laurentian University)
Hidaka, T. (2022) · Springer theses · doi:10.1007/978-981-16-8436-4_1
Measurement of Hydrogen Sulfide Metabolites Using the Monobromobimane Method
Shen, X., Speers, E. H., & Kevil, C. G. (2022) · doi:10.1002/9781119799900.ch6
Brancaleone, V., Bucci, M., & Cirino, G. (2022) · doi:10.1002/9781119799900.ch16
Mammalian study techniques that have advanced H2S investigations in plant science
Leite, A. C. R., Sales, M. V. D. S., & Queiroz, M. I. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99035-6.00007-5
Ranjana, M., Kashyap, N. N., Mitra, P. K., Sunil, D., Sudhakar, Y. N., Vennapusa, S. R., Raju, R., Tittonen, I. J., & Upadhya, D. (2024) · Materials Research Express · doi:10.1088/2053-1591/ad94d3
The Elucidation of Hydrogen Sulfide Signalling Through Persulfidation
Kouroussis, E. (2019) · theses.fr (ABES) · doi:10.70675/7d7beb54z2f84z43cdz8a1fz2342abbe3731
Lu, K., Wu, C., Fang, T., Hou, Y., Zheng, C., & Lu, C. (2026) · Antioxidants · doi:10.3390/antiox15060746
Han, M., Sun, X., Mu, Y., Li, J., Zhang, Y., Xu, H., Zhao, J., Zhao, S., Ma, K., Jia, J., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1966245
Metadata
- Authors
- Levitt, M. D., Abdel-Rehim, M. S., & Furne, J.
- Affiliations
- University of Minnesota (US)
- Veterans Health Administration (US)
- Corresponding author
- Levitt, Michael D.
- ORCID
- Levitt, Michael D.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-07-15
- Volume
- 15
- Issue
- 2
- Pages
- 373-378
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2058206341
- Cited by
- 177
- References
- 29
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 11 · 2023: 11 · 2022: 15 · 2021: 15 · 2020: 12 · 2019: 11 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 12 · 2012: 13
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- hydrogen sulfide, gasotransmitters, aorta, vasodilation, intracellular signaling, mouse tissues
- MeSH terms
- Animals, Aorta, Hydrogen Sulfide, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
