The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Free and Acid-Labile Hydrogen Sulfide Concentrations in Mouse Tissues: Anomalously High Free Hydrogen Sulfide in Aortic Tissue
Abstract
Endogenously produced hydrogen sulfide is thought to function as an intracellular messenger. There is, however, little information on tissue concentrations of free hydrogen sulfide, the putative messenger form of this molecule, versus that of the bound (acid-labile) form. The present report describes the application of a novel technique to measure free and acid-labile hydrogen sulfide in mouse tissues. Very low free hydrogen sulfide concentrations (<0.050 μmol/kg) were observed in brain, liver, blood, heart, kidney, striated muscle, and esophagus. Aortic concentrations of free hydrogen sulfide were 20 to 100 times greater than that of the other tissues. Acid-labile hydrogen sulfide concentrations were multiple orders of magnitude greater than that of the free form in every tissue other than aorta. Previous reports of tissue hydrogen sulfide concentrations of 30 to >100 μmol/kg measured bound rather than free hydrogen sulfide, the observation that aorta contains anomalously high free hydrogen sulfide concentrations lends support for a vasodilator function for this molecule, and the very low free hydrogen sulfide concentrations in most tissues seemingly requires intermediation of a yet to be described receptor-like mechanism if this molecule is to serve as a gasotransmitter.
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“As with nitrite [78], sulfide concentrations in rodents are higher in tissues than in blood, and the highest concentrations are observed in the vasculature [79], rendering the aorta a relevant target for the interaction of nitrite with sulfide.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [79]
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Spinelli, J. B., & Haigis, M. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0124-1 · Cited by 1,935
Chemical Biology of H 2 S Signaling through Persulfidation
Filipović, M. R., Živanović, J., Álvarez, B., & Banerjee, R. V. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,059
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Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
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Metadata
- Authors
- Levitt, M. D., Abdel-Rehim, M. S., & Furne, J.
- Affiliations
- University of Minnesota (US)
- Veterans Health Administration (US)
- Corresponding author
- Levitt, Michael D.
- ORCID
- Levitt, Michael D.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-07-15
- Volume
- 15
- Issue
- 2
- Pages
- 373-378
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2058206341
- Cited by
- 177
- References
- 29
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 11 · 2023: 11 · 2022: 15 · 2021: 15 · 2020: 12 · 2019: 11 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 12 · 2012: 13
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- hydrogen sulfide, gasotransmitters, aorta, vasodilation, intracellular signaling, mouse tissues
- MeSH terms
- Animals, Aorta, Hydrogen Sulfide, Mice
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