The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Hydrogen Sulfide: An Endogenous Mediator of Resolution of Inflammation and Injury
Open accessAbstract
SIGNIFICANCE: Hydrogen sulfide is emerging as an important mediator of many aspects of inflammation, and perhaps most importantly as a factor promoting the resolution of inflammation and repair of injury. RECENT ADVANCES: In the gastrointestinal tract, H(2)S has been shown to promote healing of ulcers and the resolution of mucosal inflammation. On the other hand, suppression of endogenous H(2)S synthesis impairs mucosal defense and leads to increased granulocyte infiltration. H(2)S has been exploited in the design of more effective and safe anti-inflammatory drugs. CRITICAL ISSUES: Enteric bacteria can be a significant source of H(2)S, which could affect mucosal integrity; indeed, luminal H(2)S can serve as an alternative to oxygen as a metabolic substrate for mitochondrial respiration in epithelial cells. Enterocytes and colonocytes thereby represent a "metabolic barrier" to the diffusion of bacteria-derived H(2)S into the subepithelial space. A compromise of this barrier could result in modulation of mucosal function and integrity by bacterial H(2)S. FUTURE DIRECTIONS: Improvements in methods for measurement of H(2)S and development of more selective inhibitors are crucial for gaining a better understanding of the pathophysiological importance of this mediator. Results from animal studies suggest that H(2)S-releasing agents are promising therapeutic agents for many indications, but these compounds need to be assessed in a clinical setting.
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Cites
Resolution of in flammation: state of the art, definitions and terms
Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., & Wallace, J. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-7227rev · Cited by 1,045 · cited 4×
“Counteracting the effects of these pro-inflammatory mediators are a variety of soluble mediators that down-regulate inflammation, including lipoxins, certain prostaglandins, annexin-1 (AnxA-1), and IL-10 (49).”
InfluentialSelf-citationAnnexin A1 and glucocorticoids as effectors of the resolution of inflammation
Perretti, M., & D'Acquisto, F. (2009) · Nature Reviews Immunology · doi:10.1038/nri2470 · Cited by 915
Magee, E. A., Richardson, C. J., Hughes, R., & Cummings, J. H. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.6.1488 · Cited by 359
Hydrogen sulfide-releasing anti-inflammatory drugs
Wallace, J. L. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.09.003 · Cited by 328 · cited 3×
“The ability of H2S to enhance gastrointestinal resistance to injury, to promote repair of damaged tissue, and to reduce mucosal inflammation make it an attractive substance to exploit in designing novel drugs for treatment of gastrointestinal injury and inflammation (10, 54).”
Self-citationWallace, J. L., Caliendo, G., Santagada, V., Cirino, G., & Fiorucci, S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.042 · Cited by 271
Self-citationHydrogen sulfide enhances ulcer healing in rats
Wallace, J. L., Dicay, M., McKnight, W., & Martin, G. R. (2007) · The FASEB Journal · doi:10.1096/fj.07-8669com · Cited by 236
Self-citationDistrutti, E., Sediari, L., Mencarelli, A., Renga, B., Orlandi, S., Russo, G., Caliendo, G., Santagada, V., Cirino, G., Wallace, J. L., et al. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.106435 · Cited by 144
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Cited by
Gasotransmitters in cancer: from pathophysiology to experimental therapy
Szabo, C. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.1 · Cited by 717
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Cirino, G., Szabo, C., & Papapetropoulos, A. (2023) · Physiological Reviews · doi:10.1152/physrev.00028.2021 · Cited by 553
Motta, J.-P., Flannigan, K. L., Agbor, T. A., Beatty, J. K., Blackler, R. W., Workentine, M. L., Da Silva, G. J., Wang, R., Buret, A. G., & Wallace, J. L. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000345 · Cited by 200
Self-citationAnti-Inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeutics
Wallace, J. L., Blackler, R. W., Chan, M. V., Da Silva, G. J., Elsheikh, W., Flannigan, K. L., Gamaniek, I., Manko, A., Wang, L., Motta, J.-P., et al. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2014.5901 · Cited by 156
Self-citationChiang, N., Shinohara, M., Dalli, J., Mirakaj, V., Kibi, M., Choi, A. M. K., & Serhan, C. N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202969 · Cited by 117
Metadata
- Authors
- Wallace, J. L., Ferraz, J. G. P., & Muscara, M. N.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2012-07
- Volume
- 17
- Issue
- 1
- Pages
- 58-67
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2160525912
- Cited by
- 236
- References
- 7
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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