The DOI matches its Crossref record; 192 of the 192 references it cites were found in a registry or an index.
Gasotransmitters in cancer: from pathophysiology to experimental therapy
Open accessAbstract
The three endogenous gaseous transmitters — nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) — regulate a number of key biological functions. Emerging data have revealed several new mechanisms for each of these three gasotransmitters in tumour biology. It is now appreciated that they show bimodal pharmacological character in cancer, in that not only the inhibition of their biosynthesis but also elevation of their concentration beyond a certain threshold can exert anticancer effects. This Review discusses the role of each gasotransmitter in cancer and the effects of pharmacological agents — some of which are in early-stage clinical studies — that modulate the levels of each gasotransmitter. A clearer understanding of the pharmacological character of these three gases and the mechanisms underlying their biological effects is expected to guide further clinical translation.
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Cites
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Self-citationHydrogen sulphide and its therapeutic potential
Szabó, C. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2425 · Cited by 2,038
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
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Metadata
- Authors
- Szabo, C.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2015-12-18
- Volume
- 15
- Issue
- 3
- Pages
- 185-203
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2197175751
- Cited by
- 717
- References
- 192
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- green
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