Cited by 924S100 Proteins and AnnexinsFatty Acid Research and HealthInflammatory mediators and NSAID effects

Annexin A1 and glucocorticoids as effectors of the resolution of inflammation

Perretti, Mauro, D'Acquisto, Fulvio·2009·Nature Reviews Immunology

Abstract

Glucocorticoids are widely used for the management of inflammatory diseases. Their clinical application stems from our understanding of the inhibitory effect of the corticosteroid hormone cortisol on several components of the immune system. Endogenous and exogenous glucocorticoids mediate their multiple anti-inflammatory effects through many effector molecules. In this Opinion article, we focus on the role of one such effector molecule, annexin A1, and summarize the recent studies that provide insight into its molecular and pharmacological functions in immune responses. In addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation.

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Crossref · 10.1038/nri2470

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  • Pro-resolving mediators block inflammatory cell influx, promote egress of inflammatory cells, modulate pro-inflammatory T cell responses, and promote clearance of pathogens and dead cells, limiting tissue damage and enabling repair.

    “By activating cell-surface receptors, pro-resolving mediators block inflammatory cell influx and promote the egress of inflammatory cells, modulate pro-inflammatory T cell responses and promote clearance of both pathogens and dead cells (efferocytosis), with all these functions serving to limit tissue damage and to enable the repair of injured tissue29,30.”

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Authors
Perretti, M., & D'Acquisto, F.
Affiliations
Queen Mary University of London (GB)
Corresponding author
Perretti, Mauro
Venue
Nature Reviews Immunology
Published
2009-01
Volume
9
Issue
1
Pages
62-70
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2128864178
Cited by
915
References
84
Citations by year
2026: 38 · 2025: 45 · 2024: 43 · 2023: 57 · 2022: 68 · 2021: 89 · 2020: 57 · 2019: 58 · 2018: 43 · 2017: 47 · 2016: 54 · 2015: 53 · 2014: 46 · 2013: 60 · 2012: 51
FWCI
2.68
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust
  • British Heart Foundation
  • Versus Arthritis
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
annexin A1, glucocorticoids, inflammation resolution, anti-inflammatory activity, cortisol, innate immune cells, adaptive immune cells
MeSH terms
Animals, Anti-Inflammatory Agents, Circadian Rhythm, Gene Expression Regulation, Glucocorticoids, Humans, Hydrocortisone, Immune System, Immunity, Innate, Inflammation, Macrophages, Monocytes, Neutrophils, T-Lymphocyte Subsets, Annexin A1, Mice, Knockout, Models, Immunological, Receptors, Formyl Peptide, Lipoxins, Receptors, Lipoxin, Mice

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