Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
Abstract
Glucocorticoids are widely used for the management of inflammatory diseases. Their clinical application stems from our understanding of the inhibitory effect of the corticosteroid hormone cortisol on several components of the immune system. Endogenous and exogenous glucocorticoids mediate their multiple anti-inflammatory effects through many effector molecules. In this Opinion article, we focus on the role of one such effector molecule, annexin A1, and summarize the recent studies that provide insight into its molecular and pharmacological functions in immune responses. In addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation.
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Pro-resolving mediators block inflammatory cell influx, promote egress of inflammatory cells, modulate pro-inflammatory T cell responses, and promote clearance of pathogens and dead cells, limiting tissue damage and enabling repair.
“By activating cell-surface receptors, pro-resolving mediators block inflammatory cell influx and promote the egress of inflammatory cells, modulate pro-inflammatory T cell responses and promote clearance of both pathogens and dead cells (efferocytosis), with all these functions serving to limit tissue damage and to enable the repair of injured tissue29,30.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [30]
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- Authors
- Perretti, M., & D'Acquisto, F.
- Affiliations
- Queen Mary University of London (GB)
- Corresponding author
- Perretti, Mauro
- ORCID
- Perretti, Mauro
- Venue
- Nature Reviews Immunology
- Published
- 2009-01
- Volume
- 9
- Issue
- 1
- Pages
- 62-70
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2128864178
- Cited by
- 915
- References
- 84
- Citations by year
- 2026: 38 · 2025: 45 · 2024: 43 · 2023: 57 · 2022: 68 · 2021: 89 · 2020: 57 · 2019: 58 · 2018: 43 · 2017: 47 · 2016: 54 · 2015: 53 · 2014: 46 · 2013: 60 · 2012: 51
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- British Heart Foundation
- Versus Arthritis
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- annexin A1, glucocorticoids, inflammation resolution, anti-inflammatory activity, cortisol, innate immune cells, adaptive immune cells
- MeSH terms
- Animals, Anti-Inflammatory Agents, Circadian Rhythm, Gene Expression Regulation, Glucocorticoids, Humans, Hydrocortisone, Immune System, Immunity, Innate, Inflammation, Macrophages, Monocytes, Neutrophils, T-Lymphocyte Subsets, Annexin A1, Mice, Knockout, Models, Immunological, Receptors, Formyl Peptide, Lipoxins, Receptors, Lipoxin, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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