The DOI matches its Crossref record; 344 of the 344 references it cites were found in a registry or an index.
Tetrahydrobiopterin in Cardiovascular Health and Disease
Open accessAbstract
Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthesis and recycling, versus degradation in the setting of oxidative stress. Augmenting vascular BH4 levels by pharmacological supplementation has been shown in experimental studies to enhance NO bioavailability. However, it has become more apparent that the role of BH4 in other enzymatic pathways, including other NOS isoforms and the aromatic amino acid hydroxylases, may have a bearing on important aspects of vascular homeostasis, inflammation, and cardiac function. This article reviews the role of BH4 in cardiovascular development and homeostasis, as well as in pathophysiological processes such as endothelial and vascular dysfunction, atherosclerosis, inflammation, and cardiac hypertrophy. We discuss the therapeutic potential of BH4 in cardiovascular disease states and attempt to address how this modulator of intracellular NO-redox balance may ultimately provide a powerful new treatment for many cardiovascular diseases. Antioxid. Redox Signal. 20, 3040–3077.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition, BH4 plays a critical role in the catalytic cycle of NOS (87, 204, 377, 904, 933, 1000, 1007).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [87]
Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Dellinger, R. P., Levy, M. M., Carlet, J. M., Bion, J., Parker, M. M., Jaeschke, R., Reinhart, K., Angus, D. C., Brun‐Buisson, C., Beale, R. J., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0934-2 · Cited by 6,789
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Griffith, O. W. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90139-6 · Cited by 4,628
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
Bredt, D. S., & Snyder, S. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.682 · Cited by 3,308
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512
Glutamate, nitric oxide and cell-cell signalling in the nervous system
Garthwaite, J. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90022-m · Cited by 2,401
Flagged first, then by citations
Research works printed but not linked: 6
- Ali ZA, , Alp N, , Tatham AL, , Greaves DR, , and Channon KM. Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice. Circulation, 112(17)II, 440, 2005.
- Crabtree MJ, and Channon KM. Dihydrofolate reductase is required to maintain endothelial nitric oxide synthase coupling in vivo: Insights from methotrexate-treated BH4 deficient and GTPCH overexpressing mice. Nitric Oxide, 22: S30, 2010.
- Hopkins FG. Note on Yellow Pigments in Butterflies. Nature, 40: 335, 1889.
- 10.1042/bj3490353 · DOI
- 10.1172/JCI0215215 · DOI · Paper page
- 10.1172/JCI0214442 · DOI · Paper page
Cited by
Sorted by citations
Items 101–200 of 234
Lupus serum induces inflammatory interaction with neutrophils in human glomerular endothelial cells
Russell, D. A., Markiewicz, M., & Oates, J. C. (2020) · Lupus Science & Medicine · doi:10.1136/lupus-2020-000418 · Cited by 17
Ge, Z., Li, Y., Qiao, S., Bai, X., Warltier, D. C., Kersten, J. R., Bosnjak, Z. J., & Liang, M. (2017) · Anesthesiology · doi:10.1097/aln.0000000000001926 · Cited by 17
Yuan, T.-F., Huang, H.-Q., Gao, L., Wang, S., & Li, Y. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.035 · Cited by 16
Dikalova, A., Aschner, J. L., Kaplowitz, M. R., Cunningham, G. R., Summar, M. L., & Fike, C. D. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00280.2019 · Cited by 18
Lowe, F., Luettich, K., Talikka, M., Hoang, V., Haswell, L. E., Hoeng, J., & Gaça, M. (2017) · Applied In Vitro Toxicology · doi:10.1089/aivt.2016.0031 · Cited by 17
Watanabe, T. (2020) · VASA · doi:10.1024/0301-1526/a000903 · Cited by 16
Wang, L., Cha, X., Zhang, Z., & Qian, J. (2023) · BMC Infectious Diseases · doi:10.1186/s12879-023-07983-w · Cited by 16
Chuaiphichai, S., Chu, S. M., Carnicer, R., Kelly, M., Bendall, J. K., Simon, J. N., Douglas, G., Crabtree, M. J., Casadei, B., & Channon, K. M. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00562.2022 · Cited by 16
Self-citationLin, Z., Li, P., Wu, X., Li, H., & Zeng, Z. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01154-7 · Cited by 16
Breuer, M., Guglielmi, L., Zielonka, M., Hemberger, V., Kölker, S., Okun, J. G., Hoffmann, G. F., Carl, M., Sauer, S. W., & Opladen, T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215162 · Cited by 16
Anwar, A., Yameen, D., Masood, M., Parvez, S., & Haque, M. M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148589 · Cited by 16
Acute coronary syndrome and depression: A review of shared pathophysiological pathways
Smith, I. G., Parker, G. B., Rourke, P., Cvejic, E., & Vollmer-Conna, U. S. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415597304 · Cited by 16
Utilizing proteomics to understand and define hypertension: where are we and where do we go?
Delles, C., Carrick, E., Graham, D., & Nicklin, S. A. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1493927 · Cited by 15
Jayaram, R., Jones, M., Reilly, S. N., Crabtree, M. J., Pal, N., Goodfellow, N., Nahar, K., Simon, J. N., Carnicer, R., DeSilva, R., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa302 · Cited by 16
Self-citationErectile Dysfunction: Pharmacological Pathways with Understudied Potentials
Adam, D. R., & Alem, M. M. (2022) · Biomedicines · doi:10.3390/biomedicines11010046 · Cited by 16
Peri-operative endothelial dysfunction in patients undergoing minor abdominal surgery
Ekeloef, S., Godthaab, C., Schou‐Pedersen, A. M. V., Lykkesfeldt, J., & Gögenür, I. (2018) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000000935 · Cited by 14
Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice
Madokoro, Y., Kamikokuryo, C., Niiyama, S., Ito, T., Hara, S., Ichinose, H., & Kakihana, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.929448 · Cited by 17
Panday, S., Kar, S., & Kavdia, M. (2017) · Microvascular Research · doi:10.1016/j.mvr.2017.07.001 · Cited by 14
Boehm, T., Ristl, R., Joseph, S., Petroczi, K., Klavins, K., Valent, P., & Jilma, B. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.03.043 · Cited by 13
Arefin, S., Löfgren, L., Stenvinkel, P., Granqvist, A., & Kublickiene, K. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065582 · Cited by 13
Ramasamy, S., Haque, M. M., Gangoda, M. E., & Stuehr, D. J. (2016) · FEBS Journal · doi:10.1111/febs.13933 · Cited by 13
Cai, W., Lang, M., Jiang, X., Yu, Q., Zhou, C., Zou, W., Zhang, X., & Lei, J. (2020) · Medicine · doi:10.1097/md.0000000000019548 · Cited by 13
Miotto, D. S., Dionizio, A. S., Jacomini, A. M., Zago, A. S., Buzalaf, M. A. R., & Amaral, S. L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.624515 · Cited by 12
Vujačić-Mirski, K., Oelze, M. W., Kuntić, I., Kuntić, M., Kalinovic, S., Li, H., Zielonka, J., Münzel, T. F., & Daiber, A. (2022) · Antioxidants · doi:10.3390/antiox11061182 · Cited by 10
Aging of Vascular System Is a Complex Process: The Cornerstone Mechanisms
Poznyak, A. V., Sadykhov, N. K., Kartuesov, A. G., Borisov, E. E., Sukhorukov, V. N., & Orekhov, A. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136926 · Cited by 14
Moreira, J. D., Pernomian, L., Gomes, M. S., Moreira, R. P., do Prado, A. F., da Silva, C. H. T. D. P., & de Oliveira, A. M. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.04.050 · Cited by 12
Biphasic Effect of Diabetes on Neuronal Nitric Oxide Release in Rat Mesenteric Arteries
Sastre, E., Caracuel, L., Blanco‐Rivero, J., Callejo, M., Xavier, F. E., & Balfagón, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156793 · Cited by 12
The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase
Rafea, R., Siragusa, M., & Fleming, I. (2025) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.70029 · Cited by 12
Rabender, C. S., Mezzaroma, E., Yakovlev, V. A., Mauro, A. G., Bonaventura, A., Abbate, A., & Mikkelsen, R. B. (2021) · Radiation Research · doi:10.1667/rade-20-00249.1 · Cited by 11
Wang, C., Chen, W.-S., Liu, M., Lee, C., Wang, M., Liang, C., Chu, C., Wu, H.-P., & Chen, W. (2022) · Critical Care Medicine · doi:10.1097/ccm.0000000000005640 · Cited by 11
Girish, A., Sutar, S., Murthy, T. P. K., Premanand, S. A., Garg, V., Patil, L., Shreyas, S., Shukla, R., Yadav, A. K., & Singh, T. R. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2226740 · Cited by 10
Leiva, A., Fuenzalida, B., Westermeier, F., Toledo, F., Salomón, C., Gutiérrez, J., Sanhueza, C., Pardo, F., & Sobrevía, L. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5346327 · Cited by 11
Luvuno, M., Khathi, A., & Mabandla, M. V. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00573-0 · Cited by 12
Yao, F., & Abdel‐Rahman, A. A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174406 · Cited by 10
Rudyk, O., & Eaton, P. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.07.007 · Cited by 10
Bouly, M., Bourguignon, M., Roesch, S., Rigouin, P., Gosgnach, W., Bossard, E., Royère, E., Diguet, N., Sansilvestri, P., Bonnin, A., et al. (2021) · Translational research · doi:10.1016/j.trsl.2021.07.004 · Cited by 10
Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors
Banerjee, P., Rosales, J. E., Chau, K. M., Nguyen, M. T., Kotla, S., Lin, S. H., Deswal, A. M., Dantzer, R., Olmsted‐Davis, E. A., Nguyen, H., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1186679 · Cited by 10
Schmithorst, V. J., Adams, P. S., Badaly, D., Lee, V., Wallace, J., Beluk, N., Votava‐Smith, J. K., Weinberg, J. G., Beers, S. R., Detterich, J. A., et al. (2022) · Metabolites · doi:10.3390/metabo12090882 · Cited by 9
Francis, B. N., Salameh, M., Khamisy‐Farah, R., & Farah, R. E. (2017) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12312 · Cited by 10
Prakash, S., Muhammed, I., Mohammad, Z. I. K., & Sathyanathan, S. B. (2019) · The Aging Male · doi:10.1080/13685538.2019.1647160 · Cited by 9
Jing, Z., Wang, G., Li, Z., Wu, S., Qiu, X., & Huang, R. (2023) · Chronic Diseases and Translational Medicine · doi:10.1002/cdt3.73 · Cited by 8
Role of Ferroptosis in the Redox Biology of Mycotoxins
Li, K., Zhou, R., Yin, Z., Ren, D., & Fan, S. (2025) · The FASEB Journal · doi:10.1096/fj.202501371r · Cited by 11
Altered biopterin-related cofactor metabolism in the aqueous humor of glaucoma patients
Zemītis, A., Caikovska, L., Vanags, J., Fan, J., Klavins, K., & Laganovska, G. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110778 · Cited by 8
Adhikari, H., Patel, P., Javvaji, N., Crabtree, M. J., & Simon, J. N. (2025) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2025.14 · Cited by 11
Self-citationÜnüvar, S., Melekoğlu, R., Şalva, E., Acar, C., & Yaşar, Ş. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00659-1 · Cited by 10
Alhajji, E., Boulghobra, A., Bonose, M., Berthias, F., Moussa, F., & Maı̂tre, P. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c00924 · Cited by 7
Tetrahydrobiopterin Restores Microvascular Dysfunction in Young Adult Binge Drinkers
Hwang, C., Bian, J., Thur, L. A., Peters, T. A., Piano, M. R., & Phillips, S. A. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14254 · Cited by 8
Ferric particle-assisted LDI-MS platform for metabolic fingerprinting of diabetic retinopathy
Liu, Y., Wang, Y., Wan, X., Huang, H., Shen, J., Wu, B. Y., Zhu, L., Wu, B., Liu, W., Huang, L., et al. (2023) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2023-0775 · Cited by 7
Nitric oxide releasing graphene for next-generation therapeutics
Tabish, T. A., & Lygate, C. A. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115676 · Cited by 8
Roselló‐Lletí, E., Tarazón, E., Ortega, A., Gil‐Cayuela, C., Carnicer, R., Lago, F., González‐Juanatey, J. R., Portolés, M., & Rivera, M. (2016) · Scientific Reports · doi:10.1038/srep30902 · Cited by 7
Simplified HPLC methodology for quantifying biological pterins by selective oxidation
Valdés, C., Arauna, D., González, D. R., & Villaseñor, J. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.04.018 · Cited by 7
Dhiman, K., Nath, S. K., & Ashish (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1771422 · Cited by 7
Khairallah, A., Ross, C. J., & Bishop, Ö. T. (2021) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.1c00898 · Cited by 7
Raman, S., Waskitho, A., Raju, R., Iwasa, T., Ikutame, D., Okura, K., Oshima, M., & Matsuka, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115878 · Cited by 8
Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy
Cronin, S. J. F., Andrews, N. A., & Latrémolière, A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1173599 · Cited by 7
Adamczyk, P. M., Shaw, A., Morella, I., & Morè, L. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110322 · Cited by 6
Delfani, N., Daneshyar, M., Farhoomand, P., Alijoo, Y. A., Payvastegan, S., & Najafi, G. (2022) · Journal of Animal Science and Technology · doi:10.5187/jast.2022.e68 · Cited by 6
Zhou, Q. F., Yang, F., Dai, Y., Chen, S., Zhang, F. R., Lu, L., & Lu, Q. Y. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14700 · Cited by 6
Prednisone Ameliorates Atrial Inflammation and Fibrosis in Atrial Tachypacing Dogs
Zhang, H., Lai, Y., Zhou, H., Zou, L., Xu, Y., & Yin, Y. (2022) · International Heart Journal · doi:10.1536/ihj.21-249 · Cited by 6
Tsou, Y., Wang, C., Chen, W.-S., Wu, H.-P., Liu, M., Lin, H.-C., Chang, J.-J., Tsai, M.-S., Chen, T., Cheng, C., et al. (2023) · Nutrients · doi:10.3390/nu15030649 · Cited by 6
Importance of Depressive Symptoms in Patients With Coronary Heart Disease – Review Article
Tatishvili, S., Kandashvili, T., & Gordeladze, D. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.101646 · Cited by 6
Miao, S.-H., Gao, S.-Q., Li, H., Zhuang, Y.-S., Wang, X., Li, T., Gao, C.-C., Han, Y., Qiu, J.-Y., & Zhou, M. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1121944 · Cited by 6
Wang, J., Liu, S., Qin, N., Yang, Q., Guo, H., Zhang, F., & Yin, X. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0255 · Cited by 6
Lee, S.-S., Moon, J. H., & Lee, S.-H. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.11.042 · Cited by 5
Parenteral Nutrition and Cardiotoxicity
van Nispen, J., Voigt, M., Song, E., Armstrong, A. T., Fedorova, M., Murali, V., Krebs, J., Samaddar, A., Manithody, C., & Jain, A. K. (2021) · Cardiovascular Toxicology · doi:10.1007/s12012-021-09638-1 · Cited by 5
Buschmann, K., Gramlich, Y., Chaban, R., Oelze, M. W., Hink, U., Münzel, T. F., Treede, H., Daiber, A., & Duerr, G. D. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182010892 · Cited by 5
No effect of acute tetrahydrobiopterin (BH4) supplementation on vascular dysfunction in the old
Bisconti, A. V., Garten, R. S., Broxterman, R. M., Jarrett, C. L., Park, S. H., Shields, K. L., Clifton, H. L., Ratchford, S. M., Reese, V. R., Zhao, J., et al. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00711.2021 · Cited by 5
Dhungana, G., Sampath, C., Sharma, V. D., Korolkova, O. Y., & Gangula, P. (2025) · Cells · doi:10.3390/cells14221777 · Cited by 5
Xie, L., Hu, D., Qin, H., Zhang, W., Zhang, S., Feng, Y., Yao, H., Xiao, Y., Yao, K., & Huang, X. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.01.026 · Cited by 4
GTP-cyclohydrolase deficiency induced peripheral and deep microcirculation dysfunction with age
Simonet, S., Gosgnach, W., Billou, L., Lucats, L., Royère, E., Crespo, C., Lapret, I., Ragonnet, L., Moreau, K., Vayssettes‐Courchay, C., et al. (2020) · Microvascular Research · doi:10.1016/j.mvr.2020.104078 · Cited by 4
Soares, J. P. M., Gonçalves, D. A., de Sousa, R. X., Mouro, M. G., Higa, E. M. S., Sperandio, L. P., Vitoriano, C. M., Rosa, E. B. S., dos Santos, F. O., de Queiroz, G. N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115979 · Cited by 4
Counteracting health risks by Modulating Homeostatic Signaling
Tian, J. J., Levy, M. A., Zhang, X., Sinnott, R., & Maddela, R. L. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106281 · Cited by 4
Liang, D., Shu, R., Jiang, S., Xu, M., Cai, Y., Qin, H., Zhang, D., Feng, M., Gao, J., & Meng, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012083 · Cited by 4
Suno, K., Shingu, Y., & Wakasa, S. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04451-y · Cited by 4
Tetrahydrobiopterin Concentrations in Normal and Coronary Artery Diseased Heart Tissue
Arning, E., Lowes, B. D., Taylor, M. R., Meng, X., Schiffmann, R., & Bottiglieri, T. (2016) · Journal of Cardiovascular Medicine and Cardiology · doi:10.17352/2455-2976.000023 · Cited by 4
Möller, M., Malan, L., Magnusson, M., Mels, C. M. C., & Malan, N. T. (2017) · Psychophysiology · doi:10.1111/psyp.12833 · Cited by 4
Effects Of Endothelin-1 On Intracellular Tetrahydrobiopterin Levels In Vascular Tissue
Cerrato, R., Crabtree, M. J., Antoniades, C. A., Kublickiene, K. R., Schiffrin, E. L., Channon, K. M., & Böhm, F. (2018) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2018.1453942 · Cited by 4
Self-citationBrandes, R. P. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11295 · Cited by 4
Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe?
Rahman, A. F. M. T., Benko, A. M., Bulbule, S. R., Gottschalk, C. G., Arnold, L. A., & Roy, A. (2025) · Biomolecules · doi:10.3390/biom15010102 · Cited by 3
Cary, C. M., Moore, T. L., Gow, A. J., & Stapleton, P. A. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00666.2025 · Cited by 3
Metabolomic Pathways Associated With Blood Pressure Reduction in the Chinese Heart-Healthy Diet
Chen, J., Chen, S., Huang, Z., Ye, J., Wusiman, M., Feng, K., Liu, Y., Liu, Z., Wang, Y., Sun, J., et al. (2026) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2026.01.028 · Cited by 3
Coronary Microvascular Dysfunction
Camici, P. G., Rimoldi, O. E., & Crea, F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42880-4.00005-4 · Cited by 3
Exploring PKG signaling as a therapeutic avenue for pressure overload, ischemia, and HFpEF
Zhazykbayeva, S., Budde, H., Kaçmaz, M., Zemedie, Y., Osman, H., Hassoun, R., Jaquet, K., Akın, İ., El‐Battrawy, I., Herwig, M., et al. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2400093 · Cited by 3
Pérez-Castro, C. C., Kormanovski, A., Guevara‐Balcázar, G., Castillo‐Hernández, M. D. C., García-Sánchez, J. R., Olivares-Corichi, I. M., López‐Sánchez, P., & Rubio‐Gayosso, I. (2022) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2023.27.1.9 · Cited by 3
NO Signaling Defects in Hypertension
Fleming, I. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00023-5 · Cited by 3
Amraei, R., Lampl, N. M., Nist, K. M., Zhang, Y., & Wainford, R. D. (2024) · Physiological Genomics · doi:10.1152/physiolgenomics.00052.2024 · Cited by 2
Chatturong, U., Nuengchamnong, N., Inchan, A., To‐on, K., Bualeong, T., Sumsakul, W., Atipimonpat, A., Meekarn, K., Shigeta, Y., Hengphasatporn, K., et al. (2025) · Pharmaceuticals · doi:10.3390/ph18101500 · Cited by 2
Kouhsar, S. S., Bigdeli, M., Shakiba, Y., & Sadeghniiat‐Haghighi, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-55244-1 · Cited by 2
Zhou, Q. F., Yang, F., Lu, Q. Y., Zhang, F. R., Qu, B., & Lu, L. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-04433-6 · Cited by 2
Wang, Y., Cao, Y., & Zhao, Y. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00781-y · Cited by 2
Possible Pivotal Role of Latent Chronic T. gondii Infection in the Pathogenesis of Atherosclerosis
PRANDOTA, J. (2017) · Journal of Cardiology and Therapy · doi:10.17554/j.issn.2309-6861.2017.04.130 · Cited by 2
Національний науковий центр «Інститут кардіології імені академіка М.Д. Стражеска» НАМН України, К., & В.О., Ш. (2021) · Український медичний часопис · doi:10.32471/umj.1680-3051.143.207515 · Cited by 2
Connections Between Micronutrients, Cerebral Monoamines and Related Brain Disorders
Baier, M. P., Salman, M. G., & Awwad, H. O. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-6467-0_11 · Cited by 2
Khudhur, Z. O., & Maulood, I. M. M. (2023) · Baghdad Science Journal · doi:10.21123/bsj.2023.7594 · Cited by 2
Aziz, M. Y., & Chik, Z. (2019) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2019.1625376 · Cited by 2
Vitamin B12 and Folic Acid Levels in Patients with Breath Holding Spells
Aydın, H., Bucak, İ. H., & ERDOĞAN, S. (2022) · Turkish Journal of Pediatric Disease · doi:10.12956/tchd.1094163 · Cited by 1
The value of phenylalanine in predicting atrial fibrillation risk in chronic heart failure
Zhou, Q.-F., Lu, Q., Dai, Y., Chen, Q., He, X., Chen, S., Zhao, J.-T., Zhang, F., Lu, L., & Yang, F. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1392548 · Cited by 1
Mohammadi, M., Siobal, M., Isensee, J., Ostermann, P. N., & Hucho, T. B. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70271 · Cited by 1
Understanding Different Signaling Involved During Oxidative Stress
Shelke, P., Buradi, R., & Mishra, A. (2026) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-032-19837-2_3 · Cited by 1
Exploration biologique de la fonction endothéliale
Bellien, J. (2020) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(20)30199-4 · Cited by 1
Metadata
- Authors
- Bendall, J. K., Douglas, G., McNeill, E., Channon, K. M., & Crabtree, M. J.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2014-06
- Volume
- 20
- Issue
- 18
- Pages
- 3040-3077
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- PMC
- PMC4038990
- OpenAlex
- W2092784951
- Cited by
- 231
- References
- 340
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 15 · 2023: 22 · 2022: 26 · 2021: 20 · 2020: 21 · 2019: 18 · 2018: 18 · 2017: 21 · 2016: 15 · 2015: 12 · 2014: 9
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Antioxidants and Redox Signaling (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (090532)
- National Institute for Health and Care Research (NF-SI-0508-10247)
- British Heart Foundation (RE/08/004, RG/12/5/29756, RG/12/5/29576)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- tetrahydrobiopterin, BH4, endothelial nitric oxide synthase, nitric oxide bioavailability, oxidative stress, aromatic amino acid hydroxylases, atherosclerosis, endothelial dysfunction, vascular dysfunction, inflammation, cardiac hypertrophy, cardiovascular disease, BH4 supplementation, cardiovascular homeostasis
- MeSH terms
- Biopterins, Cardiovascular Diseases, Cardiovascular System, Cardiomegaly, Humans, Inflammation, Oxidation-Reduction, Atherosclerosis, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review