Channon, Keith M.

A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography

Oikonomou, E. K., Williams, M. C., Kotanidis, C. P., Desai, M. Y., Marwan, M., Antonopoulos, A. S., Thomas, K. E., Thomas, S., Akoumianakis, I., Fan, L. M., et al. (2019) · European Heart Journal

Cardiovascular Disease and AdiposityRadiomics and Machine Learning in Medical Imaging

Cited by 534

5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide Production in Human Vessels: Effects on Vascular Tetrahydrobiopterin Availability and Endothelial Nitric Oxide Synthase Coupling

Antoniades, C., Shirodaria, C., Warrick, N., Cai, S., de Bono, J., Lee, J., Leeson, P., Neubauer, S., Ratnatunga, C., Pillai, R., et al. (2006) · Circulation

Nitric Oxide and Endothelin EffectsFolate and B Vitamins Research

Cited by 365

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Cronin, S. J. F., Seehus, C., Weidinger, A., Talbot, S., Reissig, S., Seifert, M., Pierson, Y., McNeill, E., Longhi, M. S., Turnes, B. L., et al. (2018) · Nature

T-cell and B-cell ImmunologyBiochemical and Molecular Research

Cited by 285

Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease

Guzik, T. J., Sadowski, J., Guzik, B., Jopek, A., Kapelak, B., Przybyłowski, P., Wierzbicki, K., Korbut, R., Harrison, D. G., & Channon, K. M. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology

Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 278

Effects of High-Dose Modified-Release Nicotinic Acid on Atherosclerosis and Vascular Function

Lee, J. M. S., Robson, M. D., Yu, L.-M., Shirodaria, C. C., Cunnington, C., Kylintireas, I., Digby, J. E., Bannister, T., Handa, A., Wiesmann, F., et al. (2009) · Journal of the American College of Cardiology

Lipoproteins and Cardiovascular HealthCardiovascular Health and Disease Prevention

Cited by 246

Tetrahydrobiopterin in Cardiovascular Health and Disease

Bendall, J. K., Douglas, G., McNeill, E., Channon, K. M., & Crabtree, M. J. (2014) · Antioxidants & Redox Signaling

Nitric Oxide and Endothelin EffectsFolate and B Vitamins Research

Cited by 231

Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling

Antoniades, C., Bakogiannis, C., Leeson, P., Guzik, T. J., Zhang, M.-H., Tousoulis, D., Antonopoulos, A. S., Demosthenous, M., Marinou, K., Hale, A., et al. (2011) · Circulation

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 219

Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling

Crabtree, M. J., Tatham, A. L., Hale, A. B., Alp, N. J., & Channon, K. M. (2009) · Journal of Biological Chemistry

Nitric Oxide and Endothelin EffectsFolate and B Vitamins Research

Cited by 210

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

Crabtree, M. J., Tatham, A. L., Al-Wakeel, Y., Warrick, N., Hale, A. B., Cai, S., Channon, K. M., & Alp, N. J. (2009) · Journal of Biological Chemistry

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 200

Novel quantitative phenotypes of exercise training in mouse models

De Bono, J. P., Adlam, D., Paterson, D. J., & Channon, K. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Cardiovascular and exercise physiologyPhysical Activity and Health

Cited by 197

Increased Endothelial Tetrahydrobiopterin Synthesis by Targeted Transgenic GTP-Cyclohydrolase I Overexpression Reduces Endothelial Dysfunction and Atherosclerosis in ApoE-Knockout Mice

Alp, N. J., McAteer, M. A., Khoo, J., Choudhury, R. P., & Channon, K. M. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 194

Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease

Cunnington, C., Van Assche, T., Shirodaria, C., Kylintireas, I., Lindsay, A. C., Lee, J. M., Antoniades, C., Margaritis, M., Lee, R., Cerrato, R., et al. (2012) · Circulation

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 166

Endothelial Nox2 Overexpression Potentiates Vascular Oxidative Stress and Hemodynamic Response to Angiotensin II: Studies in Endothelial-Targeted Nox2 Transgenic Mice

Bendall, J. K., Rinze, R., Adlam, D., Tatham, A. L., de Bono, J., & Channon, K. M. (2007) · Circulation Research

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 157

Altered Plasma Versus Vascular Biopterins in Human Atherosclerosis Reveal Relationships Between Endothelial Nitric Oxide Synthase Coupling, Endothelial Function, and Inflammation

Antoniades, C., Shirodaria, C., Crabtree, M., Rinze, R., Alp, N., Cunnington, C., Diesch, J., Tousoulis, D., Stefanadis, C., Leeson, P., et al. (2007) · Circulation

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 153

Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia

Cosentino, F., Hürlimann, D., Delli Gatti, C., Chenevard, R., Blau, N., Alp, N. J., Channon, K. M., Eto, M., Lerch, P., Enseleit, F., et al. (2008) · Heart

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 143

Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE−/− mice

Douglas, G., Bendall, J. K., Crabtree, M. J., Tatham, A. L., Carter, E. E., Hale, A. B., & Channon, K. M. (2012) · Cardiovascular Research

Nitric Oxide and Endothelin EffectsAtherosclerosis and Cardiovascular Diseases

Cited by 111

Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

Kohlhauer, M., Dawkins, S., Costa, A. S. H., Lee, R., Young, T., Pell, V. R., Choudhury, R. P., Banning, A. P., Kharbanda, R. K., Study, O. A. M. I. (., et al. (2018) · Journal of the American Heart Association

Cardiac Ischemia and ReperfusionAcute Myocardial Infarction Research

Cited by 91

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling

Crabtree, M. J., Brixey, R., Batchelor, H., Hale, A. B., & Channon, K. M. (2013) · Journal of Biological Chemistry

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 83

Cell-Autonomous Role of Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation

Chuaiphichai, S., McNeill, E., Douglas, G., Crabtree, M. J., Bendall, J. K., Hale, A. B., Alp, N. J., & Channon, K. M. (2014) · Hypertension

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 63