Adverse Effects of Nrf2 in Different Organs and the Related Diseases

Transcriptional Regulation by Nrf2

Tonelli, C., Chio, I. I. C., & Tuveson, D. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7342 · Cited by 2,206 · see citing works

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,158 · see citing works

Ferroptosis as a target for protection against cardiomyopathy

Fang, X., Wang, H., Han, D., Xie, E., Yang, X., Wei, J., Gu, S., Gao, F., Zhu, N., Yin, X., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821022116 · Cited by 2,142 · see citing works

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.003 · Cited by 1,205 · see citing works

Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription*

Huang, H.-C., Nguyen, T., & Pickett, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206911200 · Cited by 1,070 · see citing works

NRF2 and cancer: the good, the bad and the importance of context

Sporn, M. B., & Liby, K. T. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3278 · Cited by 1,067 · see citing works

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

de Zeeuw, D., Akizawa, T., Audhya, P., Bakris, G. L., Chin, M. P., Christ‐Schmidt, H., Goldsberry, A., Houser, M. T., Krauth, M., Heerspink, H. J. L., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1306033 · Cited by 1,041 · see citing works

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

Pergola, P. E., Raskin, P., Toto, R. D., Meyer, C. J., Huff, J. W., Grossman, E. B., Krauth, M., Ruiz, S., Audhya, P., Christ-Schmidt, H., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105351 · Cited by 890 · see citing works

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., KOTSUJI, T., Otsuka, F., Roop, D. R., et al. (2003) · Nature Genetics · doi:10.1038/ng1248 · Cited by 881 · see citing works

Regulation of Nrf2—an update

Niture, S. K., Khatri, R., & Jaiswal, A. K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.008 · Cited by 873 · see citing works

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

Zhang, Q., Liu, J., Duan, H., Li, R., Peng, W., & Wu, C. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.06.023 · Cited by 841 · see citing works

Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy

Liu, J., Han, X., Zhang, T., Tian, K., Li, Z., & Luo, F. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01512-7 · Cited by 718 · see citing works

Fundamentals of redox regulation in biology

Sies, H., Mailloux, R. J., & Jakob, U. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00730-2 · Cited by 546 · see citing works

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage

Bae, S. H., Sung, S. H., Oh, S. Y., Lim, J. M., Lee, S. K., Park, Y. N., Lee, H. E., Kang, D., & Rhee, S. G. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.002 · Cited by 492 · see citing works

FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

Zhang, X., Hu, C., Kong, C., Song, P., Wu, H., Xu, S., Yuan, Y., Deng, W., Ma, Z., & Tang, Q. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0372-z · Cited by 446 · see citing works

Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway

Liu, S., Pi, J., & Zhang, Q. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102389 · Cited by 445 · see citing works

Interplay of oxidative stress, cellular communication and signaling pathways in cancer

Iqbal, M. J., Kabeer, A., Abbas, Z., Siddiqui, H. A., Călina, D. C., Sharifi‐Rad, J., & Cho, W. C. S. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01398-5 · Cited by 426 · see citing works

Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in Murine Macrophages

Ishii, T., Itoh, K., Ruiz, E., Leake, D. S., Unoki‐Kubota, H., Yamamoto, M. P., & Mann, G. E. (2004) · Circulation Research · doi:10.1161/01.res.0000119171.44657.45 · Cited by 400 · see citing works

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

Kawai, Y., Garduño, L., Theodore, M., Yang, J., & Arinze, I. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.208173 · Cited by 355 · see citing works

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

Yu, M., Li, H., Liu, Q., Liu, F., Tang, L., Li, C., Yuan, Y., Zhan, Y., Xu, W., Li, W., et al. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.01.014 · Cited by 319 · see citing works

Molecular Basis of the KEAP1-NRF2 Signaling Pathway

Suzuki, T., Takahashi, J. A., & Yamamoto, M. P. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.0028 · Cited by 309 · see citing works

Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element–Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells

Keum, Y., Yu, S., Chang, P. P.-J., Yuan, X., Kim, J. H., Xu, C., Han, J., Agarwal, A., & Kong, A. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3513 · Cited by 305 · see citing works

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

Freigang, S., Ampenberger, F., Spohn, G., Heer, S., Shamshiev, A. T., Kisielow, J., Hersberger, M., Yamamoto, M., Bachmann, M. F., & Kopf, M. (2011) · European Journal of Immunology · doi:10.1002/eji.201041316 · Cited by 300 · see citing works

Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

Pi, J., Leung, L., Xue, P., Wang, W., Hou, Y., Liu, D., Yehuda‐Shnaidman, E., Lee, C., Lau, J., Kurtz, T. W., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.093955 · Cited by 299 · see citing works

Oxidative stress and the role of redox signalling in chronic kidney disease

Kishi, S., Nagasu, H., Kidokoro, K., & Kashihara, N. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00775-0 · Cited by 283 · see citing works

Phosphatidylinositol 3-Kinase Regulates Nuclear Translocation of NF-E2-Related Factor 2 through Actin Rearrangement in Response to Oxidative Stress

Kang, K. W., Lee, S. J., Park, J. W., & Kim, S. G. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.5.1001 · Cited by 272 · see citing works

Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man

Jaïs, A., Einwallner, E., Sharif, O., Gossens, K., Lu, T. T.-H., Soyal, S. M., Medgyesi, D., Neureiter, D., Paier-Pourani, J., Dalgaard, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.043 · Cited by 270 · see citing works

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

Fão, L., Mota, S. I., & Rego, A. C. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100942 · Cited by 270 · see citing works

Impaired liver regeneration in Nrf2 knockout mice: role of ROS‐mediated insulin/IGF‐1 resistance

Beyer, T. A., Xu, W., Teupser, D., Keller, U. A. D., Bugnon, P., Hildt, E., Thiery, J., Kan, Y. W., & Werner, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601950 · Cited by 267 · see citing works

Beyond repression of Nrf2: An update on Keap1

Kopacz, A., Klóska, D., Forman, H. J., Józkowicz, A., & Grochot‐Przeczek, A. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.023 · Cited by 262 · see citing works

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

Taguchi, K., Maher, J. M., Suzuki, T., Kawatani, Y., Motohashi, H., & Yamamoto, M. P. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01591-09 · Cited by 225 · see citing works

Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases

George, M., Tharakan, M., Culberson, J. W., Reddy, A. P., & Reddy, P. H. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101756 · Cited by 212 · see citing works

Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression

Nezu, M., Souma, T., Yu, L., Suzuki, T., Saigusa, D., Ito, S., Suzuki, N., & Yamamoto, M. P. (2016) · Kidney International · doi:10.1016/j.kint.2016.08.023 · Cited by 211 · see citing works

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

Duan, J., Cui, J., Yang, Z., Guo, C., Cao, J., Xi, M., Weng, Y., Yin, Y., Wang, Y., Wei, G., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1406-7 · Cited by 211 · see citing works

Antioxidant peptides, the guardian of life from oxidative stress

Zhu, Y., Wang, K., Jia, X., Fu, C., Yu, H., & Wang, Y. (2023) · Medicinal Research Reviews · doi:10.1002/med.21986 · Cited by 192 · see citing works

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

Xu, J., Kulkarni, S. R., Donepudi, A. C., More, V. R., & Slitt, A. L. (2012) · Diabetes · doi:10.2337/db11-1716 · Cited by 185 · see citing works

Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation

Zhao, C., Gillette, D. D., Li, X., Zhang, Z., & Wen, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.563114 · Cited by 185 · see citing works

Nrf2 Represses FGF21 During Long-Term High-Fat Diet–Induced Obesity in Mice

Chartoumpekis, D. V., Ziros, P. G., Psyrogiannis, A. I., Papavassiliou, A. G., Kyriazopoulou, V. E., Sykiotis, G. P., & Habeos, I. G. (2011) · Diabetes · doi:10.2337/db11-0112 · Cited by 184 · see citing works

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

Sussan, T. E., Jun, J. C., Thimmulappa, R. K., Bedja, D., Antero, M. F., Gabrielson, K. L., Polotsky, V. Y., & Biswal, S. S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003791 · Cited by 179 · see citing works

Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases

Hu, B., Ouyang, Y., Zhao, T., Wang, Z., Yan, Q., Qian, Q., Wang, W., & Wang, S. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303817 · Cited by 170 · see citing works

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection

Barajas, B., Che, N., Yin, F., Rowshanrad, A., Orozco, L. D., Gong, K., Wang, X., Castellani, L. W., Reue, K., Lusis, A. J., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.210906 · Cited by 169 · see citing works

Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1

Wu, Q., Wang, Y., Senitko, M., Meyer, C. J., Wigley, W. C., Ferguson, D. A., Grossman, E. B., Chen, J., Zhou, X. J., Hartono, J. R., et al. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00353.2010 · Cited by 158 · see citing works

Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

Fülöp, G., Kiss, T., Tarantini, S., Balasubramanian, P., Yabluchanskiy, A., Farkas, E., Bari, F., Ungvari, Z. I., & Csiszár, A. (2018) · GeroScience · doi:10.1007/s11357-018-0047-6 · Cited by 157 · see citing works

The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase

Sanghvi, V. R., Leibold, J., Mina, M., Mohan, P., Berishaj, M., Li, Z., Miele, M. M., Lailler, N., Zhao, C., de Stanchina, E., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.031 · Cited by 155 · see citing works

Downregulation of Nuclear Factor Erythroid 2–Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension

Alves-Lopes, R., Neves, K. B., Tostes, R. C., Montezano, A. C. I., & Touyz, R. M. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.06163 · Cited by 133 · see citing works

Puerarin reverses cadmium-induced lysosomal dysfunction in primary rat proximal tubular cells via inhibiting Nrf2 pathway

Wang, L., Fan, R., Yang, D.-B., Zhang, D., & Wang, L. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.10.016 · Cited by 128 · see citing works

MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1/NRF2 interaction

Luo, X., Wang, Y., Zhu, X., Chen, Y., Xu, B., Bai, X., Weng, X., Xu, J., Tao, Y., Yang, D., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102987 · Cited by 128 · see citing works

Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: Role of mitogen-activated protein kinases and Nrf2

Anwar, A. A., Li, F. Y. L., Leake, D. S., Ishii, T., Mann, G. E., & Siow, R. C. M. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.03.012 · Cited by 122 · see citing works

Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCFFBXL17 in NRF2 Activation via BACH1 Repressor Turnover

Tan, M.-K. M., Lim, H.-J., Bennett, E. J., Shi, Y., & Harper, J. W. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.018 · Cited by 118 · see citing works

Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy

Lian, C.-Y., Chu, B., Xia, W.-H., Wang, Z., Fan, R., & Wang, L. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.04.016 · Cited by 117 · see citing works

Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice

Zhao, S., Ghosh, A., Lo, C., Chénier, I., Scholey, J. W., Filep, J. G., Ingelfinger, J. R., Zhang, S., & Chan, J. S. D. (2017) · Endocrinology · doi:10.1210/en.2017-00752 · Cited by 115 · see citing works

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

Zang, H., Wu, W., Qi, L., Tan, W., Nagarkatti, P. S., Nagarkatti, M., Wang, X., & Cui, T. (2020) · Diabetes · doi:10.2337/db19-1176 · Cited by 115 · see citing works

The KEAP1-NRF2 System and Neurodegenerative Diseases

Uruno, A., & Yamamoto, M. P. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0234 · Cited by 111 · see citing works

The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains

Kim, J.-H., Yu, S., Chen, J. D., & Kong, A.-N. T. (2012) · Oncogene · doi:10.1038/onc.2012.59 · Cited by 110 · see citing works

The absence of macrophage Nrf2 promotes early atherogenesis

Ruotsalainen, A.-K., Inkala, M., Partanen, M. E., Lappalainen, J. P., Kansanen, E., Mäkinen, P. I., Heinonen, S. E., Laitinen, H. M., Heikkilä, J., Vatanen, T., et al. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt008 · Cited by 109 · see citing works

Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases

Xiang, Y., Song, X., & Long, D. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03660-8 · Cited by 109 · see citing works

Reactive Oxygen Species and NRF2 Signaling, Friends or Foes in Cancer?

Wang, R., Liang, L., Matsumoto, M., Iwata, K., Umemura, A., & He, F. (2023) · Biomolecules · doi:10.3390/biom13020353 · Cited by 105 · see citing works

Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease

Lv, Q.-K., Tao, K., Yao, X., Pang, M., Cao, B., Liu, C., & Wang, F. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12948 · Cited by 103 · see citing works

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

Kaspar, J. W., & Jaiswal, A. K. (2010) · The FASEB Journal · doi:10.1096/fj.10-171553 · Cited by 99 · see citing works

Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements

Maruyama, A., Tsukamoto, S., Nishikawa, K., Yoshida, A., Harada, N., Motojima, K., Ishii, T., Nakane, A., Yamamoto, M. P., & Itoh, K. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.06.004 · Cited by 99 · see citing works

Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: Involvement of the adaptive antioxidant response

Xue, P., Hou, Y., Zhang, Q., Woods, C. G., Yarborough, K., Liu, H., Sun, G., Andersen, M. E., & Pi, J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.03.024 · Cited by 97 · see citing works

KPNA6 (Importin α7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response

Sun, Z., Wu, T., Zhao, F. L., Lau, A., Birch, C. M., & Zhang, D. D. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05036-11 · Cited by 97 · see citing works

Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy

Kannan, S., Muthusamy, V. R., Whitehead, K. J., Wang, L., Gomes, A. V., Litwin, S. E., Kensler, T. W., Abel, E. D., Hoidal, J. R., & Rajasekaran, N. S. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt150 · Cited by 96 · see citing works

Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice

Song, J., Zhang, Y., Frieler, R. A., Andren, A. C., Wood, S. C., Tyrrell, D. J., Sajjakulnukit, P., Deng, J. C., Lyssiotis, C. A., Mortensen, R. M., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci173034 · Cited by 96 · see citing works

The Dark Side of Nrf2 in the Heart

Zang, H., Mathew, R. O., & Cui, T. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00722 · Cited by 93 · see citing works

The Multifaceted Roles of NRF2 in Cancer: Friend or Foe?

Glorieux, C., Enriquez-Lara, C., González, C. D., Aguirre-Martínez, G. V., & Calderón, P. B. (2024) · Antioxidants · doi:10.3390/antiox13010070 · Cited by 91 · see citing works

Nrf2-Mediated Cardiac Maladaptive Remodeling and Dysfunction in a Setting of Autophagy Insufficiency

Qin, Q., Chen, Q., Niu, T., Zang, H., Qi, L., Lyu, L., Wang, X., Nagarkatti, M., Nagarkatti, P. S., Janicki, J. S., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.06062 · Cited by 89 · see citing works

c‐Jun NH2‐Terminal Protein Kinase Phosphorylates the Nrf2‐ECH Homology 6 Domain of Nuclear Factor Erythroid 2–Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen‐Induced Liver Injury in Mice

Chen, Y., Liu, K., Zhang, J., Hai, Y., Wang, P., Wang, H., Liu, Q., Wong, C. C. L., Yao, J., Gao, Y., et al. (2020) · Hepatology · doi:10.1002/hep.31116 · Cited by 88 · see citing works

Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis

Köhler, U. A., Kurinna, S. M., Schwitter, D., Marti, A. T., Schäfer, M., Hellerbrand, C., Speicher, T., & Werner, S. (2013) · Hepatology · doi:10.1002/hep.26964 · Cited by 84 · see citing works

KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease

Antognelli, C., Trapani, E., Monache, S. D., Perrelli, A., Daga, M., Pizzimenti, S., Barrera, G., Cassoni, P., Angelucci, A., Trabalzini, L., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.014 · Cited by 81 · see citing works

Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice

Wang, Z., Ka, S., Lee, Y., Park, B., & Bae, E. J. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.02.021 · Cited by 78 · see citing works

Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway

Wu, J., Liu, X., Fan, J., Chen, W., Wang, J., Zeng, Y., Feng, X., Yu, X., & Yang, X. (2014) · Toxicology · doi:10.1016/j.tox.2014.01.008 · Cited by 77 · see citing works

Nuclear Factor E2-Related Factor 2 Mediates Oxidative Stress-Induced Lipid Accumulation in Adipocytes by Increasing Adipogenesis and Decreasing Lipolysis

Sun, X., Li, X., Jia, H., Wang, H., Shui, G., Qin, Y., Shu, X. Y., Wang, Y., Dong, J., Liu, G., et al. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7769 · Cited by 77 · see citing works

Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I

Zeng, H., Wang, L., Zhang, J., Pan, T. S., Yu, Y., Lu, J., Zhou, P., Yang, H. Q., & Li, P. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.09.006 · Cited by 73 · see citing works

Glial HO-1 expression, iron deposition and oxidative stress in neurodegenerative diseases

Schipper, H. M. (1999) · Neurotoxicity Research · doi:10.1007/bf03033339 · Cited by 72 · see citing works

Reductive stress impairs myogenic differentiation

Rajasekaran, N. S., Shelar, S. B., Jones, D. P., & Hoidal, J. R. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101492 · Cited by 70 · see citing works

Nrf2 Activation in Chronic Kidney Disease: Promises and Pitfalls

Aranda‐Rivera, A. K., Cruz‐Gregorio, A., Pedraza‐Chaverrí, J., & Scholze, A. (2022) · Antioxidants · doi:10.3390/antiox11061112 · Cited by 70 · see citing works

Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice

Rush, B. M., Bondi, C. D., Stocker, S. D., Barry, K. M., Small, S., Ong, J., Jobbagy, S., Stolz, D. B., Bastacky, S., Chartoumpekis, D. V., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.07.036 · Cited by 64 · see citing works

Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways

Li, Y., Zhou, M., Li, H., Dai, C., Yin, L., Liu, C., Li, Y., Zhang, E., Dong, X., Ji, H., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad796 · Cited by 55 · see citing works

Neurotherapeutic effects of novel HO ‐1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease

Gupta, A., Lacoste, B., Pistell, P. J., Ingram, D. K., Hamel, É., Alaoui‐Jamali, M. A., Szarek, W. A., Vlahakis, J. Z., Su, J., Song, W., et al. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12927 · Cited by 54 · see citing works

Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction

Shanmugam, G., Wang, D., Gounder, S. S., Fernandes, J., Litovsky, S. H., Whitehead, K. S., Radhakrishnan, R. K., Franklin, S., Hoidal, J. R., Kensler, T. W., et al. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7808 · Cited by 52 · see citing works

Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance

Meher, A. K., Sharma, P. R., Lira, V. A., Yamamoto, M. P., Kensler, T. W., Yan, Z., & Leitinger, N. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.022 · Cited by 51 · see citing works

Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration

Chan, B. K., Elmasry, M., Forootan, S. S., Russomanno, G., Bunday, T., Zhang, F., Brillant, N., Lewis, P. J. S., Aird, R. E., Ricci, E., et al. (2021) · Hepatology · doi:10.1002/hep.31859 · Cited by 51 · see citing works

Reductive stress promotes protein aggregation and impairs neurogenesis

Narasimhan, K. K. S., Devarajan, A., Karan, G., Sundaram, S., Wang, Q., van Groen, T., del Monte, F., & Rajasekaran, N. S. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101739 · Cited by 47 · see citing works

Heme oxygenase-1 overexpression exacerbates heart failure with aging and pressure overload but is protective against isoproterenol-induced cardiomyopathy in mice

Allwood, M. A., Kinobe, R. T., Ballantyne, L. L., Romanova, N. A., Melo, L. G., Ward, C. A., Brunt, K. R., & Simpson, J. A. (2014) · Cardiovascular Pathology · doi:10.1016/j.carpath.2014.03.007 · Cited by 46 · see citing works

Natural Allies for Heart Health: Nrf2 Activation and Cardiovascular Disease Management

Khan, S. U., Khan, S. U., Suleman, M., Khan, S. U., Suleman, M., Arbi, F. M., Hussain, T., Alsuhaibani, A. M., & Refat, M. S. E.-D. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102084 · Cited by 46 · see citing works

Role of HNF4alpha-cMyc interaction in liver regeneration and recovery after acetaminophen-induced acute liver injury

Kotulkar, M., Paine‐Cabrera, D., Abernathy, S., Robarts, D. R., Parkes, W. S., Lin‐Rahardja, K., Numata, S., Lebofsky, M., Jaeschke, H., & Apte, U. M. (2023) · Hepatology · doi:10.1097/hep.0000000000000367 · Cited by 43 · see citing works

Nrf2 is essential for timely M phase entry of replicating hepatocytes during liver regeneration

Zou, Y., Hu, M., Lee, J., Nambiar, S. M., Garcia, V., Bao, Q., Chan, J. Y., & Dai, G. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00332.2014 · Cited by 42 · see citing works

Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD

Lewis, J. H., Jadoul, M. Y., Block, G. A., Chin, M. P., Ferguson, D. A., Goldsberry, A., Meyer, C. J., O’Grady, M., Pérgola, P. E., Reisman, S. A., et al. (2020) · Clinical and Translational Science · doi:10.1111/cts.12868 · Cited by 41 · see citing works

Oxidative stress, Nrf2 and keratin up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria

Singla, A., Moons, D. S., Snider, N. T., Wagenmaker, E. R., Jayasundera, B. V., & Omary, M. B. (2012) · Hepatology · doi:10.1002/hep.25664 · Cited by 39 · see citing works

The Potential Role of Major Argan Oil Compounds as Nrf2 Regulators and Their Antioxidant Effects

Kebbaj, R. E., Bouchab, H., Tahri-Joutey, M., Rabbaa, S., Limami, Y., Nasser, B., Egbujor, M. C., Tucci, P., Andreoletti, P., Saso, L., et al. (2024) · Antioxidants · doi:10.3390/antiox13030344 · Cited by 38 · see citing works

GAS41 modulates ferroptosis by anchoring NRF2 on chromatin

Wang, Z., Yang, X. P., Chen, D., Liu, Y., Li, Z., Duan, S., Zhang, Z., Jiang, X., Stockwell, B. R., & Gu, W. J. (2024) · Nature Communications · doi:10.1038/s41467-024-46857-w · Cited by 38 · see citing works

Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice

Ghosh, A., Abdo, S., Zhao, S., Wu, C., Shi, Y., Lo, C., Chénier, I., Alquier, T., Filep, J. G., Ingelfinger, J. R., et al. (2017) · Endocrinology · doi:10.1210/en.2016-1576 · Cited by 37 · see citing works

Identification of transcriptome signature for myocardial reductive stress

Quiles, J. M., Narasimhan, M., Mosbruger, T. L., Shanmugam, G., Crossman, D. K., & Rajasekaran, N. S. (2017) · Redox Biology · doi:10.1016/j.redox.2017.07.013 · Cited by 33 · see citing works

Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium

Bartolini, D., Arato, I., Mancuso, F., Giustarini, D., Bellucci, C., Vacca, C., Aglietti, M. C., Stabile, A. M., Rossi, R., Cruciani, G., et al. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12806 · Cited by 31 · see citing works

Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress

Quiles, J. M., Pepin, M. E., Sunny, S., Shelar, S. B., Challa, A. K., Dalley, B. K., Hoidal, J. R., Pogwizd, S. M., Wende, A. R., & Rajasekaran, N. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-90583-y · Cited by 29 · see citing works

Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice

Sawada, H., Saito, Y., & Noguchi, N. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.08.023 · Cited by 26 · see citing works

A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter

Nishihara, E., Hishinuma, A., Kogai, T., Takada, N., Hirokawa, M., Fukata, S., Ito, M., Yabuta, T., Nishikawa, M., Nakamura, H., et al. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00131 · Cited by 24 · see citing works

CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome

Pagnotta, S. E., Tramutola, A., Barone, E., Domenico, F. D., Pittalà, V., Salerno, L., Folgiero, V., Caforio, M., Locatelli, F., Petrini, S., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.03.006 · Cited by 24 · see citing works

Copper induces liver lipotoxicity disease by up-regulating Nrf2 expression via the activation of MTF-1 and inhibition of SP1/Fyn pathway

Zhong, C.-C., Zhao, T., Högstrand, C., Song, C.-C., Zito, E., Tan, X.-Y., Xu, Y.-C., Song, Y., Wei, X., & Luo, Z. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166752 · Cited by 24 · see citing works

SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway

Tan, V. W. T., Salmi, T. M., Karamalakis, A. P., Gillespie, A., Ong, A. J. S., Balic, J. J., Chan, Y.-C., Bladen, C. E., Brown, K., Dawson, M. A., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.01.024 · Cited by 24 · see citing works

Nrf2 in adipocytes

Wang, Z., Zuo, Z., Li, L., Ren, S., Gao, T., Fu, J., Hou, Y., Chen, Y., & Pi, J. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01227-0 · Cited by 22 · see citing works

Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance

Gu, L., Du, Y., Chen, J., Hasan, M. N., Clayton, Y. D., Matye, D. J., Friedman, J. E., & Li, T. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2320934121 · Cited by 22 · see citing works

Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift

Ogawa, K., Noda, A., Ueda, J., Ogata, T., Matsuyama, R., Nishizawa, Y., Qiao, S., Iwata, S., Ito, M., Fujihara, Y., et al. (2020) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-020-00232-x · Cited by 20 · see citing works

Endothelial TET2 regulates the white adipose browning and metabolism via fatty acid oxidation in obesity

Shi, Y., Huang, X., Zeng, Y., Zhai, M., Yao, H., Liu, C., Li, B., Gong, S., Yu, Q., Zhuang, J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.103013 · Cited by 20 · see citing works

Transgenic Expression of Nrf2 Induces a Pro-Reductive Stress and Adaptive Cardiac Remodeling in the Mouse

Jyothidasan, A., Sunny, S., Murugesan, S., Quiles, J. M., Challa, A. K., Dalley, B. K., Cinghu, S., Nanda, V., & Rajasekaran, N. S. (2022) · Genes · doi:10.3390/genes13091514 · Cited by 18 · see citing works

Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins

Coombs, G. S., Rios-Monterrosa, J. L., Lai, S., Dai, Q., Goll, A. C., Ketterer, M. R., Valdes, M. F., Uche, N., Benjamin, I. J., & Wallrath, L. L. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102196 · Cited by 17 · see citing works

Impaired hepatic autophagy exacerbates hepatotoxin induced liver injury

Byrnes, K. G., Bailey, N. T., Baral, K., Mercer, A., Joshi, S., Wahby, N., Rorison, T., Liu, G., Yin, X., & Khambu, B. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01368-3 · Cited by 14 · see citing works

Redox signaling in ischemic postconditioning protection involves PKCε and Erk1/2 pathways and converges indirectly in Nrf2 activation

Díaz-Ruiz, J. L., Macías‐López, A., Alcalá-Vargas, F., Guevara-Chávez, J.-G., Mejía-Uribe, A., Silva‐Palacios, A., Zúñiga-Muñoz, A. M., Zazueta, C., & Buelna‐Chontal, M. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109417 · Cited by 13 · see citing works

Exercise mitigates reductive stress-induced cardiac remodeling in mice

Jyothidasan, A., Sunny, S., Devarajan, A., Sayed, A., Afortude, J. K., Dalley, B. K., Nanda, V., Pogwizd, S. M., Litovsky, S. H., Trinity, J. D., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103263 · Cited by 9 · see citing works

Sodium Houttuybonate Promotes the Browning of White Adipose Tissue by Inhibiting Ferroptosis via the AMPK-NRF2-HO1 Pathway

Liu, W., Zou, H., You, D., Zhang, H., & Xu, L. (2024) · Antioxidants · doi:10.3390/antiox13091057 · Cited by 6 · see citing works

Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis

Xiong, M., Peng, J., Zhou, S., Gao, Q., Lu, J., Chen, O., Song, H., & Peng, Q. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1571554 · Cited by 10 · see citing works

Melatonin-Mediated Nrf2 Activation as a Potential Therapeutic Strategy in Mutation-Driven Neurodegenerative Diseases

Íñigo-Catalina, L., Ortiz-Cabello, M., Navarro, E., Esteras, N., Rancán, L., & Paredes, S. D. (2025) · Antioxidants · doi:10.3390/antiox14101190 · Cited by 8 · see citing works

NRF2–KEAP1 as a redox signal-resolution circuit: Beyond the antioxidant switch

Sailis, A. B. (2026) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2026.03.005 · Cited by 8 · see citing works

The oxidative stress-inflammation self-perpetuating cycle in multiple sclerosis: from mechanisms to emerging antioxidant strategies

Yuan, B., Jin, X., Li, C., Shen, Y., Tian, J., & Duan, S. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1806176 · Cited by 5 · see citing works

Characteristics of Adverse Events and Clinical Risks of Omaveloxolone Based on FAERS Data

Liu, H., Fan, D., Hong, T., Shen, Z., & Yao, K. (2025) · The Cerebellum · doi:10.1007/s12311-025-01873-4 · Cited by 5 · see citing works

Microbial proteases as emerging anti-inflammatory therapeutics: a comprehensive review

Suresh, A., & Vaithilingam, M. (2025) · Archives of Microbiology · doi:10.1007/s00203-025-04409-w · Cited by 3 · see citing works

Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture

Qi, G., Ma, T., Wang, Y., Chen, K., Yan, Y., Li, Z., Deng, N., Tseng, C., Li, B., Zheng, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72683-3 · Cited by 2 · see citing works

Effect of L-theanine on the hippocampus, cerebral cortex and cerebellum of doxorubicin-treated rats

Kural, B. V., Kör, S., Malkoç, M. A., ÖZTÜRK, H., Durmus, T. B., Yuluğ, E., Aydın-Abidin, S., Abidin, İ., & Örem, A. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.153216 · Cited by 1 · see citing works

Uncovering biological patterns across studies through automated large-scale reanalyses of public transcriptomic dataPreprint

Chen, K., & Lassmann, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.04.686647

Targeted Nrf2 activation improves vascular endothelial function with aging and prevents vascular dysfunction following disuse in younger and older adults

Carlini, N. A., Hanson, B. E., Ruple, B. A., Craig, J. C., Fermoyle, C. C., McKenzie, A. I., Bisconti, A. V., Pelka, E. Z., Supiano, M. A., Tuday, E. C., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.282

The diving reflex elicits potent, non-electrophilic Nrf2 activation via trigeminal CGRP signaling

Li, C., Powell, K., Wadolowski, S., Jacob, A., LeDoux, C., Brenner, M., & Wang, P. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.306

Kidney Risks Linked to Per‐ and Polyfluoroalkyl Substance Exposure

Chávez‐Valencia, V., & Lagunas‐Rangel, F. A. (2026) · Environmental Toxicology · doi:10.1002/tox.70197

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works

Transcriptional Regulation by Nrf2

Tonelli, C., Chio, I. I. C., & Tuveson, D. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7342 · Cited by 2,206 · see citing works

Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease

Aleksunes, L. M., & Manautou, J. E. (2007) · Toxicologic Pathology · doi:10.1080/01926230701311344 · Cited by 285 · see citing works

The role of Nrf2 transcription factors in various physiological and pathological states

Yastani, D., & Jusman, S. W. A. (2024) · Acta Biochimica Indonesiana · doi:10.32889/actabioina.103 · Cited by 4 · see citing works

The Advanced Study on the Function of Nrf2-ARE Pathway

Qu-lon, D. (2015) · Journal of International Obstetrics and Gynecology · Cited by 1 · see citing works