Default mode network engagement beyond self-referential internal mentation
Open accessAbstract
The default mode network (DMN) is typically associated with off-task internal mentation, or with goal-oriented tasks that require self-referential processing such as autobiographical planning. However, recent reports suggest a broader involvement of the DMN in higher cognition. In line with this view, we report global connectivity changes that are centered on the main DMN hubs of precuneus and posterior cingulate cortex during a functional magnetic resonance imaging-based visuospatial version of the Tower of London planning task. Importantly, functional connectivity of these regions with the left caudate shows a significant relationship with faster reaction time to correct responses only during the high-demand planning condition, thus offering further evidence for the DMN's engagement during visuospatial planning. The results of this study not only provide robust evidence against the widely held notion of DMN disengagement during goal-oriented, attention-demanding, externally directed tasks but also support its involvement in a broader cognitive context with a memory-related role that extends beyond self-referential, internally directed mentation.
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Brain regions within the default mode network display the latest maturation age of peak.
“brain regions within the default mode network, which is involved broadly in high-level cognition (Raichle, 2015; Vatansever et al., 2018; 2017), display the latest maturation age of peak.”
From Quantitative mapping of the brain’s structural connectivity using diffusion MRI tractography: A review (2022) · cites this paper as Vatansever et al., 2018
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The brain's default network and its adaptive role in internal mentation
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“Although the involvement of precuneus in either the FPN or the DMN (Buckner et al., 2008; Margulies et al., 2009) has been debated, recent reports have established it as a core DMN region (Utevsky et al., 2014) contributing to task performance in attention-demanding paradigms such as working memory…”
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Zhang, F., Daducci, A., He, Y., Schiavi, S., Seguin, C., Smith, R. E., Yeh, C.-H., Zhao, T., & O’Donnell, L. J. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2021.118870 · Cited by 302 · see citing works
“For instance, following an inverted U-shaped trajectory, the peak ages of network efficiency and small-world measures (30 years) fall within the range of peak ages on general cognitive performance (Schaie, 2005; Schroeder and Salthouse, 2004), and brain regions within the default mode network, which is involved broadl…”
- Authors
- Vatansever, D., Manktelow, A., Sahakian, B. J., Menon, D. K., & Stamatakis, E. A.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Vatansever, Deniz
- Venue
- Brain Connectivity
- Publisher
- SAGE Publications
- Published
- 2018-05
- Volume
- 8
- Issue
- 4
- Pages
- 245-253
- ISSN
- 2158-0014 (ISSN-L)
- 2158-0022
- OpenAlex
- W2792434514
- Cited by
- 42
- References
- 10
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 2
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- green
- orcid.org
- Locations
- Brain Connectivity (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- National Institute for Health and Care Research
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- default mode network, Tower of London, precuneus, posterior cingulate cortex, caudate nucleus, functional connectivity, reaction time, goal-directed cognition, memory, self-referential processing
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Processes, Middle Aged, Models, Neurological, Neural Pathways, Oxygen
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