The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
The Neurobiology of Impulsive Aggression
Open accessAbstract
This selective review provides a model of the neurobiology of impulsive aggression from a cognitive neuroscience perspective. It is argued that prototypical cases of impulsive aggression, those associated with anger, involve the recruitment of the acute threat response system structures; that is, the amygdala, hypothalamus, and periaqueductal gray. It is argued that whether the recruitment of these structures results in impulsive aggression or not reflects the functional roles of ventromedial frontal cortex and dorsomedial frontal and anterior insula cortex in response selection. It is also argued that impulsive aggression may occur because of impaired decision making. The aggression may not be accompanied by anger, but it will reflect disrupted evaluation of the rewards/benefits of the action.
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“In addition, the insula has also been reported to mediate the states of anger, aggression, and social emotion [62,[67][68][69].”
From The Insular Cortex: An Interface Between Sensation, Emotion and Cognition (2024) · cites this paper as [68]
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Cites
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Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · cited 1×
“The dominant view is that the vmPFC inhibits (‘‘puts the brakes on’’) the aggressive responses mediated by the amygdala, hypothalamus, and PAG ( Nelson and Trainor 2007; Schiller and Delgado 2010; Diekhof et al. 2011; Etkin et al. 2011).”
BackgroundSelf-Control in Decision-Making Involves Modulation of the vmPFC Valuation System
Hare, T. A., Camerer, C. F., & Rangel, A. (2009) · Science · doi:10.1126/science.1168450 · Cited by 1,928
Cognitive Reappraisal of Emotion: A Meta-Analysis of Human Neuroimaging Studies
Buhle, J. T., Silvers, J. A., Wager, T. D., Lopez, R., Onyemekwu, C., Kober, H., Weber, J., & Ochsner, K. N. (2014) · Cerebral Cortex · doi:10.1093/cercor/bht154 · Cited by 1,896 · cited 1×
“For example, the fMRI literature indicates that the vmPFC is not involved in emotional regulation (Buhle et al. 2014).”
BackgroundAmygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203
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Two types of aggression in human evolution.
Wrangham, R. W. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713611115 · Cited by 410
Pediatric Irritability: A Systems Neuroscience Approach
Leibenluft, E. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.02.002 · Cited by 179
The Insular Cortex: An Interface Between Sensation, Emotion and Cognition
Zhang, R., Deng, H., & Xiao, X. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01211-4 · Cited by 158
Andrewes, D. G., & Jenkins, L. M. (2019) · Neuropsychology Review · doi:10.1007/s11065-019-09398-4 · Cited by 169
Blair, J. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0155 · Cited by 124
Metadata
- Authors
- Blair, R. J. R.
- Affiliations
- National Institutes of Health
- Venue
- Journal of Child and Adolescent Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2016-02
- Volume
- 26
- Issue
- 1
- Pages
- 4-9
- ISSN
- 1044-5463 (ISSN-L)
- 1557-8992
- PMC
- PMC4779272
- OpenAlex
- W2245990605
- Cited by
- 235
- References
- 71
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 29 · 2023: 31 · 2022: 20 · 2021: 36 · 2020: 28 · 2019: 15 · 2018: 13 · 2017: 9 · 2016: 5
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Child and Adolescent Psychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (1-ZIA-MH002860, 1‑ZIA‑MH002860‑08, ZIAMH002860)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
- Keywords
- impulsive aggression, neurobiology of aggression, amygdala, hypothalamus, periaqueductal gray, ventromedial prefrontal cortex, dorsomedial prefrontal cortex, anterior insula, response selection, decision-making, reward evaluation, anger
- MeSH terms
- Aggression, Brain, Humans, Impulsive Behavior, Neurobiology
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