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Cited by 40Diabetes Management and ResearchDiabetes Management and EducationDiabetes Treatment and Management

ROSSO-in-praxi-international: long-term effects of self-monitoring of blood glucose on glucometabolic control in patients with type 2 diabetes mellitus not treated with insulin

Kempf, Kerstin, Tankova, Tsvetalina, Martin, Stephan·2013·Diabetes Technology & Therapeutics
DOI 10.1089/dia.2012.0213
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Abstract

BACKGROUND: Effects of lifestyle change on blood glucose levels can be monitored by self-monitoring of blood glucose (SMBG) in type 2 diabetes mellitus (T2DM) patients. We analyzed whether the SMBG-structured lifestyle intervention program ROSSO-in-praxi-international can improve glucometabolic control in the short and the long term. SUBJECTS AND METHODS: One hundred twenty-four SMBG-naive ambulatory non-insulin-treated T2DM patients were randomly assigned to an SMBG group (n=63) and a control group (n=61). Both groups received a 12-week structured lifestyle guidance manual. The SMBG group additionally got a blood glucose meter with 150 test strips and was instructed to measure blood glucose regularly as well as event-driven. Glucometabolic parameters were assessed at baseline, after 12 weeks, and after 1.5 years. RESULTS: During the 12 weeks of intervention the SMBG group significantly improved glycated hemoglobin (HbA1c) levels (from 7.4 ± 1.6% to 6.9 ± 1.1% [P<0.001]) and weight (-0.9 ± 1.9 kg [P<0.05]), whereas HbA1c reduction (from 7.5 ± 1.0% to 7.3 ± 1.0%) and weight loss (-0.6 ± 2.4 kg) were not significant in the control group. Of the 124 patients, 122 completed the 1.5-year follow-up. In the control group HbA1c increased again, reaching baseline values (7.5 ± 0.7%). In the SMBG group HbA1c remained stable (6.9 ± 0.9% [P=0.0003 for trend]), and weight (-1.6 ± 3.0 kg vs. baseline [P=0.0003 for trend]) improved further. Eighty-seven percent of participants in the SMBG group continued to perform SMBG. Those who measured their blood glucose more than three times per week (n=24) demonstrated an overall reduction in HbA1c of 1.0% (P=0.006 vs. three times or fewer per week) after 1.5 years. CONCLUSIONS: Integration of SMBG into basic therapy of T2DM for monitoring the effect of lifestyle changes improves glucometabolic control and has long-term effects.

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Authors
Kempf, K., Tankova, T., & Martin, S.
Affiliations
  • Westdeutsches Diabetes- und GesundheitsZentrum (DE)
  • Medical University of Sofia (BG)
  • West-German Centre of Diabetes and Health, Düsseldorf Catholic Hospital Group, Düsseldorf, Germany.
Corresponding author
Kempf, Kerstin
ORCID
Venue
Diabetes Technology & Therapeutics
Publisher
SAGE Publications
Published
2013-01
Volume
15
Issue
1
Pages
89-96
ISSN
  • 1520-9156 (ISSN-L)
  • 1557-8593
DOI
10.1089/dia.2012.0213
OpenAlex
W2069377137
Cited by
40
References
13
Citations by year
2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 1
FWCI
3.08
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Diabetes Technology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Roche Diabetes Care
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
self-monitoring of blood glucose, type 2 diabetes, non-insulin-treated diabetes, lifestyle intervention, HbA1c, weight loss, long-term glycemic control, blood glucose meters
MeSH terms
Blood Glucose, Bulgaria, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Glycated Hemoglobin, Humans, Male, Middle Aged, Patient Compliance, Patient Education as Topic, Prospective Studies, Time, Time Factors, Blood Glucose Self-Monitoring, Treatment Outcome, Risk Reduction Behavior

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