Automated insulin delivery in elderly with type 1 diabetes: a prespecified analysis of the extension phase
Open accessAbstract
The Automated Insulin Delivery in Elderly with Type 1 Diabetes (AIDE T1D) trial randomized 82 adults ≥65 years with type 1 diabetes (T1D) to hybrid closed loop (HCL), predictive low glucose suspend (PLGS), and sensor-augmented pump (SAP) therapy in a randomized crossover trial. Seventy-five of the 78 completers joined an extension phase in which they were offered the pump mode of their choice for an additional 3 months. Mean age was 71 ± 4 years (range 65-86 years) and mean duration of T1D was 42 ± 17 years (range 1-68 years). Use of HCL was selected by 91%, PLGS by 8%, and continuous glucose monitoring with injections by 1%. For participants selecting HCL, time-in-range 70-180 mg/dL was similar in the randomized controlled trial and extension phase (mean 75% ± 10%). One severe hypoglycemic event was reported. HCL was preferred over PLGS or SAP and remained effective in older adults with T1D. Clinical Trial Registration: NCT04016662.
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In the extension phase of the AIDE T1D study, 91% of the participants chose the AID system.
“In the extension phase of the study, 91% of the participants chose the AID system (55).”
From 13. Older Adults: Standards of Care in Diabetes—2026 (2026) · cites this paper as [55]
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2. Diagnosis and Classification of Diabetes: <i>Standards of Care in Diabetes—2024</i>
American Diabetes Association Professional Practice Committee, ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Gaglia, J. L., Hilliard, M. E., Johnson, E. L., et al. (2024) · Diabetes Care · doi:10.2337/dc24-s002 · Cited by 2,086 · see citing works
Self-citation13. Older Adults: <i>Standards of Care in Diabetes—2024</i>
American Diabetes Association Professional Practice Committee, ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Hilliard, M. E., Johnson, E. L., Khunti, K., et al. (2024) · Diabetes Care · doi:10.2337/dc24-s013 · Cited by 161 · see citing works
Self-citationBoughton, C. K., Hartnell, S., Thabit, H., Mubita, W. M., Draxlbauer, K., Poettler, T., Wilinska, M. E., Hood, K. K., Mader, J. K., Narendran, P., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00005-8 · Cited by 127 · see citing works
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Research works printed but not linked: 2
- [2]2. Kudva YC, , Henderson RJ, , Kanapka LG, et al. Automated insulin delivery in older adults with Type 1 Diabetes. NEJM Evid, 2025; 4(1):EVIDoa2400200; doi: 10.1056/EVIDoa2400200 [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
- [4]4. McAuley SA, , Trawley S, , Vogrin S, et al. Closed-Loop insulin delivery versus sensor-augmented pump therapy in older adults with Type 1 Diabetes (ORACL): A randomized, crossover trial. Diabetes Care, 2022; 45(2):381–390; doi: 10.2337/dc21-1667 [DOI] [PubMed] [Google Scholar] · DOI · Paper page
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13. Older Adults: Standards of Care in Diabetes—2026
American Diabetes Association Professional Practice Committee for Diabetes*, Bajaj, M., McCoy, R. G., Balapattabi, K., Bannuru, R. R., Bellini, N. J., Bennett, A. K., Beverly, E. A., Briggs Early, K., ChallaSivaKanaka, S., et al. (2026) · Diabetes Care · doi:10.2337/dc26-s013 · Cited by 87 · see citing works
- Authors
- Kudva, Y. C., Henderson, R. J., Kanapka, L. G., Weinstock, R. S., Rickels, M. R., Pratley, R. E., Chaytor, N., Janess, K., Desjardins, D., Pattan, V., Peleckis, A. J., Casu, A., Rizvi, S. R., Bzdick, S., Whitaker, K. J., Kamimoto, J. L. J., Miller, K., Kollman, C., Beck, R. W., & for the AIDE study group
- Affiliations
- Mayo Clinic (US)
- Jaeb Center for Health Research (US)
- SUNY Upstate Medical University (US)
- University of Pennsylvania (US)
- AdventHealth Orlando (US)
- Washington State University Spokane (US)
- Elkhart Clinic (US)
- T1D Exchange (US)
- ORCID
- Venue
- Diabetes Technology & Therapeutics
- Publisher
- SAGE Publications
- Published
- 2025-03-11
- Volume
- 27
- Issue
- 7
- Pages
- 572-575
- ISSN
- 1520-9156 (ISSN-L)
- 1557-8593
- PMC
- PMC13398333
- OpenAlex
- W4408328596
- Cited by
- 7
- References
- 3
- Citations by year
- 2026: 3 · 2025: 4
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Locations
- Diabetes Technology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- National Institutes of Health (UL1TR001878)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK122603)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 1 diabetes, older adults, artificial pancreas, hybrid closed-loop system, predictive low glucose suspend, sensor-augmented pump, continuous glucose monitoring, time in range, hypoglycemia, extension phase
- MeSH terms
- Aged, Aged, 80 and over, Blood Glucose, Diabetes Mellitus, Type 1, Female, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Male, Blood Glucose Self-Monitoring, Cross-Over Studies
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