Long Noncoding RNA EBF3-AS Promotes Neuron Apoptosis in Alzheimer's Disease
Abstract
Alzheimer's disease (AD) is the most common form of dementia; its pathophysiological mechanism remains unclear. Long noncoding RNAs (lncRNAs) play key roles in AD. lncRNA EBF3-AS has been found dysregulated in AD, which is abundantly expressed in the brain. The aim of this study was to investigate the role of EBF3-AS in AD. Results showed that the expressions of lncRNA EBF3-AS and EBF3 (early B cell factor 3) were upregulated in hippocampus of APP/PS1 mice (AD model mice). EBF3-AS knockdown by siRNA inhibited the apoptosis induced by Aβ25–35 and okadaic acid (OA) in SH-SY5Y. The expression of EBF3 was downregulated in Aβ25–35- and OA-treated SH-SY5Y, which was reversed by EBF3-AS knockdown. EBF3 knockdown can reverse the Aβ25–35-induced apoptosis in SH-SY5Y. These results revealed that lncRNA EBF3-AS promoted neuron apoptosis in AD, and involved in regulating EBF3 expression. EBF3-AS may be a new therapeutic target for treatment of AD.
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The lncRNA EBF3-AS is upregulated in the brain of AD mice.
“The lncRNA EBF3-AS is upregulated in the brain of AD mice, and downregulation of EBF3-AS can reduce Aβ-induced neuronal apoptosis [618].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [618]
Downregulation of EBF3-AS can reduce Aβ-induced neuronal apoptosis.
“The lncRNA EBF3-AS is upregulated in the brain of AD mice, and downregulation of EBF3-AS can reduce Aβ-induced neuronal apoptosis [618].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [618]
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Self-citation
- Authors
- Gu, C., Chen, C., Wu, R., Dong, T., Hu, X., Yao, Y., & Zhang, Y.
- Affiliations
- Gansu Provincial Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Corresponding author
- Zhang, Yi
- Venue
- DNA and Cell Biology
- Publisher
- SAGE Publications
- Published
- 2018-03
- Volume
- 37
- Issue
- 3
- Pages
- 220-226
- ISSN
- 1044-5498 (ISSN-L)
- 1557-7430
- OpenAlex
- W2782468540
- Cited by
- 101
- References
- 20
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 14 · 2023: 11 · 2022: 17 · 2021: 16 · 2020: 17 · 2019: 12 · 2018: 7
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- DNA and Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Lanzhou University Institutional Repository (submittedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- long non-coding RNA, Alzheimer's disease, neuronal apoptosis, EBF3, amyloid-beta, okadaic acid, APP/PS1 mice, SH-SY5Y cells, hippocampus, therapeutic target
- MeSH terms
- Alzheimer Disease, Animals, Hippocampus, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Transcription Factors, Gene Expression, Amyloid beta-Peptides, Apoptosis, RNA Interference, Cell Line, Tumor, RNA, Long Noncoding
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