Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5

<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., McCormack, M. P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C. S., Pawliuk, R., Morillon, E., et al. (2003) · Science · doi:10.1126/science.1088547 · Cited by 3,587 · see citing works

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., MacDonald, M. E., Stuhlmann, H., Koup, R. A., & Landau, N. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80110-5 · Cited by 3,074 · see citing works

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.

Kim, Y. G., Cha, J., & Chandrasegaran, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1156 · Cited by 2,099 · see citing works

Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation

Hütter, G., Nowak, D., Mossner, M., Ganepola, S., Muessig, A., Allers, K., Schneider, T., Hofmann, J., Kücherer, C., Blau, O., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0802905 · Cited by 1,837 · see citing works

Human Lymphoid and Myeloid Cell Development in NOD/LtSz- scid IL2R γ null Mice Engrafted with Mobilized Human Hemopoietic Stem Cells,

Shultz, L. D., Lyons, B. L., Burzenski, L. M., Gott, B., Chen, X., Chaleff, S., Kotb, M., Gillies, S. D., King, M., Mangada, J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6477 · Cited by 1,736 · see citing works

Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone

Horwitz, E. M., Gordon, P. L., Koo, W. K. K., Marx, J. C., Neel, M. D., McNall, R. Y., Muul, L., & Hofmann, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132252399 · Cited by 1,650 · see citing works

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Urnov, F. D., Miller, J. C., Lee, Y.-L., Beausejour, C. M., Rock, J. M., Augustus, S., Jamieson, A. C., Porteus, M. H., Gregory, P. D., & Holmes, M. C. (2005) · Nature · doi:10.1038/nature03556 · Cited by 1,642 · see citing works

NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells

Ito, M., Hiramatsu, H., Kobayashi, K., Suzue, K., Kawahata, M., Hioki, K., Ueyama, Y., Koyanagi, Y., Sugamura, K., Tsuji, K., et al. (2002) · Blood · doi:10.1182/blood-2001-12-0207 · Cited by 1,483 · see citing works

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

Perez, E. E., Wang, J., Miller, J. C., Jouvenot, Y., Kim, K. A., Liu, O., Wang, N., Lee, G., Bartsevich, V. V., Lee, Y.-L., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1410 · Cited by 999 · see citing works

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice

Ishikawa, F., Yasukawa, M., Lyons, B. L., Yoshida, S., Miyamoto, T., Yoshimoto, G., Watanabe, T., Akashi, K., Shultz, L. D., & Harada, M. (2005) · Blood · doi:10.1182/blood-2005-02-0516 · Cited by 933 · see citing works

Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation

Allers, K., Hütter, G., Hofmann, J., Loddenkemper, C., Rieger, K., Thiel, E., & Schneider, T. (2011) · Blood · doi:10.1182/blood-2010-09-309591 · Cited by 681 · see citing works

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

Holt, N., Wang, J., Kim, K., Friedman, G., Wang, X., Taupin, V., Crooks, G. M., Kohn, D. B., Gregory, P. D., Holmes, M. C., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1663 · Cited by 677 · see citing works

Relative resistance to HIV–1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high–risk sexual exposures

Paxton, W. A., Martin, S. R., Tse, D. B., OʼBrien, T. R., Skurnick, J., VanDevanter, N., PADIAN, N. S., Braun, J. F., Kotler, D. P., Wolinsky, S. M., et al. (1996) · Nature Medicine · doi:10.1038/nm0496-412 · Cited by 648 · see citing works

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

Kumar, P., Ban, H., Kim, S. S., Wu, H., Pearson, T., Greiner, D. L., Laouar, A., Yao, J., Haridas, V., Habiro, K., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.034 · Cited by 573 · see citing works

T-cell repertoire diversity and clonal expansions in normal and clinical samples

Pannetier, C., Even, J., & Kourilsky, P. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80117-0 · Cited by 551 · see citing works

An unbiased genome-wide analysis of zinc-finger nuclease specificity

Gabriel, R., Lombardo, A., Arens, A., Miller, J. C., Genovese, P., Kaeppel, C., Nowrouzi, A., Bartholomae, C. C., Wang, J., Friedman, G., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1948 · Cited by 526 · see citing works

HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies

Connors, M., Kovacs, J. A., Krevat, S. A., Gea‐Banacloche, J., Sneller, M. C., Flanigan, M., Metcalf, J. A., WALKER, R. E., Falloon, J., Baseler, M., et al. (1997) · Nature Medicine · doi:10.1038/nm0597-533 · Cited by 514 · see citing works

Gene transfer in humans using a conditionally replicating lentiviral vector

Levine, B. L., Humeau, L. M. P. F., Boyer, J., MacGregor, R.-R., Rebello, T., Lü, X., Binder, G. K., Slepushkin, V., Lemiale, F., Mascola, J. R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608138103 · Cited by 505 · see citing works

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

Zhao, Y., Moon, E. K., Carpenito, C., Paulos, C. M., Liu, X., Brennan, A. L., Chew, A., Carroll, R. G., Scholler, J., Levine, B. L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2880 · Cited by 448 · see citing works

Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know

Pantaleo, G., & Koup, R. A. (2004) · Nature Medicine · doi:10.1038/nm0804-806 · Cited by 445 · see citing works

Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy

Gorochov, G., Neumann, A. U., Kereveur, A., Parizot, C., Li, T., Katlama, C., Karmochkine, M., Raguin, G., Autran, B., & Debré, P. (1998) · Nature Medicine · doi:10.1038/nm0298-215 · Cited by 426 · see citing works

Efficient Gene Transfer into Human CD34 + Cells by a Retargeted Adenovirus Vector

Shayakhmetov, D. M., Papayannopoulou, T., Stamatoyannopoulos, G., & Lieber, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2567-2583.2000 · Cited by 367 · see citing works

Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells

Levine, B. L., Bernstein, W. B., Connors, M., Craighead, N., Lindsten, T., Thompson, C. B., & June, C. H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.12.5921 · Cited by 340 · see citing works

Manufacturing Validation of Biologically Functional T Cells Targeted to CD19 Antigen for Autologous Adoptive Cell Therapy

Hollyman, D., Stefanski, J., Przybylowski, M., Bartido, S. M., Bórquez-Ojeda, O., Taylor, C., Yeh, R., Capacio, V., Olszewska, M., Hosey, J., et al. (2009) · Journal of Immunotherapy · doi:10.1097/cji.0b013e318194a6e8 · Cited by 316 · see citing works

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer

Rapoport, A. P., Stadtmauer, E. A., Aqui, N. A., Badros, A. Z., Cotte, J., Chrisley, L., Veloso, E. A., Zheng, Z., Westphal, S., Mair, R., et al. (2005) · Nature Medicine · doi:10.1038/nm1310 · Cited by 290 · see citing works

HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene

Quillent, C., Oberlin, E., Braun, J. M., Rousset, D., Gonzalez-Canali, G., Métais, P., Montagnier, L., Virelizier, J., Arenzana‐Seisdedos, F., & Beretta, A. (1998) · The Lancet · doi:10.1016/s0140-6736(97)09185-x · Cited by 270 · see citing works

Development of Antibodies to Fetal Calf Serum With Arthus-Like Reactions in Human Immunodeficiency Virus–Infected Patients Given Syngeneic Lymphocyte Infusions

Selvaggi, T. A., WALKER, R. E., & Fleisher, T. A. (1997) · Blood · doi:10.1182/blood.v89.3.776 · Cited by 269 · see citing works

Prevalence of Neutralizing Antibodies to Adenoviral Serotypes 5 and 35 in the Adult Populations of The Gambia, South Africa, and the United States

Nwanegbo, E. C., Vardas, E., Gao, W., Whittle, H. C., Sun, H., Rowe, D., Robbins, P. D., & Gambotto, A. A. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.2.351-357.2004 · Cited by 266 · see citing works

Induction of angiogenesis in a mouse model using engineered transcription factors

Rebar, E. J., Huang, Y., Hickey, R. P., Nath, A. K., Meoli, D. F., Nath, S. K., Chen, B., Xu, L., Liang, Y., Jamieson, A. C., et al. (2002) · Nature Medicine · doi:10.1038/nm1202-795 · Cited by 252 · see citing works

Long-Term Inhibition of HIV-1 Infection in Primary Hematopoietic Cells by Lentiviral Vector Delivery of a Triple Combination of Anti-HIV shRNA, Anti-CCR5 Ribozyme, and a Nucleolar-Localizing TAR Decoy

Li, M.-J., Kim, J., Li, S. X., Zaia, J. A., Yee, J., Anderson, J. S., Akkina, R., & Rossi, J. J. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.07.524 · Cited by 243 · see citing works

Regulation of an Endogenous Locus Using a Panel of Designed Zinc Finger Proteins Targeted to Accessible Chromatin Regions

Liu, P., Rebar, E. J., Zhang, L., Liu, Q., Jamieson, A. C., Liang, Y., Qi, H., Li, P.-X., Chen, B., Mendel, M. C., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011172200 · Cited by 239 · see citing works

Genetics of HIV-1infection: chemokine receptor CCR5 polymorphism and its consequences

Carrington, M. N. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.10.1939 · Cited by 235 · see citing works

Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

Eugen‐Olsen, J., Iversen, A. K. N., Garred, P., Koppelhus, U., Pedersen, C., Benfield, T., Sorensen, A. M., Katzenstein, T. L., Dickmeiss, E., Gerstoft, J., et al. (1997) · AIDS · doi:10.1097/00002030-199703110-00007 · Cited by 234 · see citing works

Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed dendritic cells

Mackensen, A., Dräger, R., Schlesier, M., Mertelsmann, R. H., & Lindemann, A. (2000) · Cancer Immunology Immunotherapy · doi:10.1007/s002620050614 · Cited by 233 · see citing works

Antiviral Effect and Ex Vivo CD4 + T Cell Proliferation in HIV-Positive Patients as a Result of CD28 Costimulation

Levine, B. L., Mosca, J. D., Riley, J. L., Carroll, R. G., Vahey, M., Jagodzinski, L. L., Wagner, K. F., Mayers, D. L., Burke, D. S., Weislow, O. S., et al. (1996) · Science · doi:10.1126/science.272.5270.1939 · Cited by 219 · see citing works

A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation

Porter, D., Levine, B. L., Bunin, N., Stadtmauer, E. A., Luger, S. M., Goldstein, S. C., Loren, A. W., Phillips, J., Nasta, S. D., Perl, A. E., et al. (2005) · Blood · doi:10.1182/blood-2005-08-3373 · Cited by 219 · see citing works

Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation

Laport, G. G., Levine, B. L., Stadtmauer, E. A., Schuster, S. J., Luger, S. M., Grupp, S. A., Bunin, N., Strobl, F. J., Cotte, J., Zheng, Z., et al. (2003) · Blood · doi:10.1182/blood-2003-01-0095 · Cited by 179 · see citing works

Immune Response to Fetal Calf Serum by Two Adenosine Deaminase-Deficient Patients After T Cell Gene Therapy

Tuschong, L. M., Soenen, S. L., Blaese, R. M., Candotti, F., & Muul, L. M. (2002) · Human Gene Therapy · doi:10.1089/10430340260201699 · Cited by 173 · see citing works

Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection

Levine, B. L., Bernstein, W. B., Aronson, N., Schlienger, K., Cotte, J., Perfetto, S. J., Humphries, M. J., Ratto‐Kim, S., Birx, D. L., Steffens, C. M., et al. (2002) · Nature Medicine · doi:10.1038/nm0102-47 · Cited by 169 · see citing works

CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4+ T cells and induce similar patterns of cytokine secretion in vitro

Levine, B. L., Ueda, Y., Craighead, N., Huang, M. L., & June, C. H. (1995) · International Immunology · doi:10.1093/intimm/7.6.891 · Cited by 155 · see citing works

Zinc-finger protein-targeted gene regulation: Genomewide single-gene specificity

Tan, S., Guschin, D. Y., Davalos, A. R., Lee, Y.-L., Snowden, A. W., Jouvenot, Y., Zhang, H. S., Howes, K., McNamara, A. R., Lai, A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2035056100 · Cited by 153 · see citing works

Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells

Nilsson, M., Ljungberg, J., Richter, J., Kiefer, T., Magnusson, M., Lieber, A., Widegren, B., Karlsson, S., & Fan, X. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.543 · Cited by 129 · see citing works

Large-Scale Production of CD4+ T Cells from HIV-1-Infected Donors After CD3/CD28 Costimulation*

Levine, B. L., Cotte, J., SMALL, C. C., Carroll, R. G., Riley, J. L., Bernstein, W. B., Epps, D. E. V., Hardwick, R. A., & June, C. H. (1998) · Journal of Hematotherapy · doi:10.1089/scd.1.1998.7.437 · Cited by 125 · see citing works

A detailed study of the substrate specificity of a chimeric restriction enzyme

Smith, J., Berg, J. M., & Chandrasegaran, S. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.2.674 · Cited by 107 · see citing works

CCR2 chemokine receptor and AIDS progression

Smith, M. W., Carrington, M. N., Winkler, C. A., Lomb, D. A., Dean, M. C., Huttley, G. A., & O’Brien, S. J. (1997) · Nature Medicine · doi:10.1038/nm1097-1052c · Cited by 99 · see citing works

Allogeneic transplantation of CCR5-deficient progenitor cells in a patient with HIV infection: An update after 3 years and the search for patient No. 2

Hütter, G., & Thiel, E. (2011) · AIDS · doi:10.1097/qad.0b013e328340fe28 · Cited by 91 · see citing works

Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells

Rapoport, A. P., Stadtmauer, E. A., Aqui, N. A., Vogl, D. T., Chew, A., Fang, H., Janofsky, S., Yager, K., Veloso, E. A., Zheng, Z., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0418 · Cited by 90 · see citing works

Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications

Leen, A. M., Sili, U., Savoldo, B., Jewell, A. M., Piedra, P. A., Brenner, M. K., & Rooney, C. M. (2003) · Blood · doi:10.1182/blood-2003-07-2449 · Cited by 86 · see citing works

Transfer of Autologous Gene-modified T Cells in HIV-infected Patients with Advanced Immunodeficiency and Drug-resistant Virus.

van Lunzen, J., Glaunsinger, T., Stahmer, I., von Baehr, V., Baum, C., Schilz, A., Kuehlcke, K., Naundorf, S., Martinius, H., Hermann, F., et al. (2007) · Molecular Therapy · doi:10.1038/mt.sj.6300124 · Cited by 81 · see citing works

Zinc-Finger Nucleases for Somatic Gene Therapy: The Next Frontier

Rahman, S. H., Maeder, M. L., Joung, J. K., & Cathomen, T. (2011) · Human Gene Therapy · doi:10.1089/hum.2011.087 · Cited by 78 · see citing works

Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID β2mnull mice

Nervi, B., Rettig, M. P., Ritchey, J., Wang, H. L., Bauer, G., Walker, J. E., Bonyhadi, M. L., BERENSON, R. J., Prior, J. L., Piwnica-Worms, D. R., et al. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.06.007 · Cited by 74 · see citing works

Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors.

Snowden, A. W., Zhang, L., Urnov, F. D., Dent, C. L., Jouvenot, Y., Zhong, X., Rebar, E. J., Jamieson, A. C., Zhang, H. S., Tan, S., et al. (2003) · PubMed · Cited by 71 · see citing works

GMP production and testing of Xcellerated T Cells™ for the treatment of patients with CLL

Hami, L., Green, C., Leshinsky, N., Markham, E., Miller, K., & Craig, S. (2004) · Cytotherapy · doi:10.1080/14653240410005348 · Cited by 66 · see citing works

Regulation of Human Cell Engraftment and Development of EBV-Related Lymphoproliferative Disorders in Hu-PBL-scid Mice

Wagar, E. J., Cromwell, M. A., Shultz, L. D., Woda, B. A., Sullivan, J. L., Hesselton, R. M., & Greiner, D. L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.518 · Cited by 63 · see citing works

Gene transfer into human T lymphocytes and natural killer cells by Ad5/F35 chimeric adenoviral vectors.

Schroers, R., Hildebrandt, Y., Hasenkamp, J., Glass, B., Lieber, A., Wulf, G., & Piesche, M. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.03.010 · Cited by 60 · see citing works

Highly Altered Vβ Repertoire of T Cells Infiltrating Long-Term Rejected Kidney Allografts

Gagne, K., Brouard, S., Giral, M., Sébille, F., Moreau, A., Guillet, M., Bignon, J., Imbert, B., Cuturi, M. C., & Soulillou, J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.3.1553 · Cited by 59 · see citing works

Chemokines as Natural HIV Antagonists

Verani, A., & Lusso, P. (2002) · Current Molecular Medicine · doi:10.2174/1566524023361862 · Cited by 58 · see citing works

Efficient clinical-scale enrichment of lymphocytes for use in adoptive immunotherapy using a modified counterflow centrifugal elutriation program

Powell, D. J., Brennan, A. L., Zheng, Z., Huynh, H. A., Cotte, J., & Levine, B. L. (2009) · Cytotherapy · doi:10.3109/14653240903188921 · Cited by 51 · see citing works

Persistent alterations in T-cell repertoire, cytokine and chemokine receptor gene expression after 1 year of highly active antiretroviral therapy

Martinon, F., Michelet, C., Péguillet, I., Taoufik, Y., Lefebvre, P., Goujard, C., Guillet, J., Delfraissy, J., & Lantz, O. J. (1999) · AIDS · doi:10.1097/00002030-199902040-00006 · Cited by 49 · see citing works

Limits of the Human-PBL-SCID Mice Model: Severe Restriction of the Vβ T-Cell Repertoire of Engrafted Human T Cells

Garcia, S., Dadaglio, G., & Gougeon, M. (1997) · Blood · doi:10.1182/blood.v89.1.329 · Cited by 48 · see citing works

Impact of gene-modified T cells on HIV infection dynamics

von Laer, D., Hasselmann, S., & Hasselmann, K. (2005) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2005.05.005 · Cited by 47 · see citing works

Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors.

Cohen, O. J., Vaccarezza, M., Lam, G. K. W., Baird, B., Wildt, K. F., Murphy, P. M., Zimmerman, P. A., Nutman, T. B., Fox, C. H., Hoover, S., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119682 · Cited by 47 · see citing works

In vitro induction of carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes by dendritic cells transduced with recombinant adenoviruses

Cho, H.-I., Kim, H., Oh, S.-T., & Kim, T. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00569-3 · Cited by 44 · see citing works

Direct Recognition of Foreign MHC Determinants by Naive T Cells Mobilizes Specific Vβ Families Without Skewing of the Complementarity-Determining Region 3 Length Distribution

Sébille, F., Gagne, K., Guillet, M., Degauque, N., Pallier, A., Brouard, S., Vanhove, B., Delsuc, M., & Soulillou, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3082 · Cited by 43 · see citing works

Different Qualitative and Quantitative Regulation of Vβ TCR Transcripts During Early Acute Allograft Rejection and Tolerance Induction

Guillet, M., Brouard, S., Gagne, K., Sébille, F., Cuturi, M. C., Delsuc, M., & Soulillou, J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5088 · Cited by 40 · see citing works

Molecular remission of CML after autotransplantation followed by adoptive transfer of costimulated autologous T cells

Rapoport, A. P., Levine, B. L., Badros, A. Z., Meisenberg, B. R., Ruehle, K., Nandi, A., Rollins, S., Natt, S., Ratterree, B., Westphal, S., et al. (2003) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704317 · Cited by 39 · see citing works

Progression of Human Immunodeficiency Virus Disease Is Associated with Increasing Disruptions within the CD4+T Cell Receptor Repertoire

Gea‐Banacloche, J., Weiskopf, E. E., Hallahan, C. W., de Quirós, J. C. L. B., Flanigan, M., Mican, J. M., Falloon, J., Baseler, M., Stevens, R. A., Lane, H. C., et al. (1998) · The Journal of Infectious Diseases · doi:10.1086/514233 · Cited by 38 · see citing works

Gene Therapy: A Bold Direction for HIV-1 Treatment*

Sarver, N., & Rossi, J. J. (1993) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1993.9.483 · Cited by 33 · see citing works

EBV-induced human B cell lymphomas in hu-PBL-SCID mice.

Mosier, D. E., Picchio, G., Kirven, M., Garnier, J. L., Torbett, B. E., Baird, S., Kobayashi, R., & Kipps, T. J. (1992) · PubMed · Cited by 32 · see citing works

Efficient gene transfer into hematopoietic cells by a retargeting adenoviral vector system with a chimeric fiber of adenovirus serotype 5 and 11p

Lu, Z., Ni, F., Hu, Z., Wang, L., Wang, H., Zhang, Q., Huang, W., Wu, C.-T., & Wang, L. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.05.005 · Cited by 31 · see citing works

High-efficiency gene transfer to primary T lymphocytes by recombinant adenovirus vectors

Chen, Z., Ahonen, M., Hämäläinen, H., Bergelson, J. M., Kähäri, V., & Lahesmaa, R. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(01)00521-x · Cited by 28 · see citing works

Gene-Based Immunotherapy for Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome

Dropulić, B., & June, C. H. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.577 · Cited by 28 · see citing works

Efficient gene transfer into normal human B lymphocytes with the chimeric adenoviral vector Ad5/F35.

Jung, D., Néron, S., Drouin, M., & Jacques, A. (2005) · JIM - Journal of Immunological Methods · doi:10.1016/j.jim.2005.06.010 · Cited by 24 · see citing works

Longitudinal Changes in CD4 + T Cell Antigen Receptor Diversity and Naive/Memory Cell Phenotype during 9 to 26 Months of Antiretroviral Therapy of HIV-Infected Patients

Gea‐Banacloche, J., Martino, L., Mican, J. M., Hallahan, C. W., Baseler, M., Stevens, R. A., Lambert, L., Polis, M. A., Lane, H. C., & Connors, M. (2000) · AIDS Research and Human Retroviruses · doi:10.1089/08892220050195838 · Cited by 23 · see citing works

Duplex Polymerase Chain Reaction Quantification of Human Cells in a Murine Background

Pelz, O., Wu, M., Nikolova, T., Kamprad, M., Ackermann, M., Egger, D., Emmrich, F., Wobus, A. M., & Cross, M. A. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0206 · Cited by 18 · see citing works

Evaluation of gp160 Vaccinees in the hu-PBL-SCID Mouse Model

Mosier, D. E., Gulizia, R. J., MacISAAC, P., Mathieson, B. J., Smith, G., Hu, S., Corey, L. G., & Greenberg, P. (1992) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1992.8.1387 · Cited by 17 · see citing works

Blocking HIV's Attack

June, C. H., & Levine, B. (2012) · Scientific American · doi:10.1038/scientificamerican0312-54 · Cited by 11 · see citing works

Evaluation of TCR Vβ subfamily T cell expansion in NOD/SCID mice transplanted with human cord blood hematopoietic stem cells

Lin, C., Chen, S., Yang, L., Tan, Y., Bai, X., & Li, Y. (2007) · Hematology · doi:10.1080/10245330701342342 · Cited by 5 · see citing works

A guide to genome engineering with programmable nucleases

Kim, S., & Kim, J. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3686 · Cited by 1,162 · see citing works

Genome Engineering with Targetable Nucleases

Carroll, D. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035418 · Cited by 541 · see citing works

Comparison of T7E1 and Surveyor Mismatch Cleavage Assays to Detect Mutations Triggered by Engineered Nucleases

Vouillot, L., Thélie, A., & Pollet, N. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.015834 · Cited by 308 · see citing works

Adoptive Immunotherapy for Cancer or Viruses

Maus, M. V., Fraietta, J. A., Levine, B. L., Kalos, M. D., Zhao, Y., & June, C. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120136 · Cited by 265 · see citing works

CAR T cells for infection, autoimmunity and allotransplantation

Maldini, C. R., Ellis, G. I., & Riley, J. L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0042-2 · Cited by 226 · see citing works

CCR5 Gene Disruption via Lentiviral Vectors Expressing Cas9 and Single Guided RNA Renders Cells Resistant to HIV-1 Infection

Wang, W., Ye, C., Liu, J., Zhang, D., Kimata, J. T., & Zhou, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115987 · Cited by 196 · see citing works

TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

Mussolino, C., Alzubi, J., Fine, E. J., Morbitzer, R., Cradick, T. J., Lahaye, T., Bao, G., & Cathomen, T. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku305 · Cited by 190 · see citing works

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells

Hultquist, J. F., Schumann, K., Woo, J. M., Manganaro, L., McGregor, M. J., Doudna, J., Simon, V., Krogan, N. J., & Marson, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.080 · Cited by 170 · see citing works

Current and future delivery systems for engineered nucleases: ZFN, TALEN and RGEN

Ain, Q. U., Chung, J. Y., & Kim, Y.-H. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.036 · Cited by 130 · see citing works

Entry inhibitors and their use in the treatment of HIV-1 infection

Haqqani, A. A., & Tilton, J. C. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.03.017 · Cited by 129 · see citing works

From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing

Hotta, A., & Yamanaka, S. (2015) · Annual Review of Genetics · doi:10.1146/annurev-genet-112414-054926 · Cited by 121 · see citing works

Vaccinomics, adversomics, and the immune response network theory: Individualized vaccinology in the 21st century

Poland, G. A., Kennedy, R. B., McKinney, B. A., Ovsyannikova, I. G., Lambert, N. D., Jacobson, R. M., & Oberg, A. L. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.04.007 · Cited by 121 · see citing works

MicroRNAs and HIV-1 Infection: Antiviral Activities and Beyond

Swaminathan, G., Navas, S., & Martín‐García, J. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.12.017 · Cited by 115 · see citing works

Zinc Fingers, TALEs, and CRISPR Systems: A Comparison of Tools for Epigenome Editing

Waryah, C. B., Moses, C., Arooj, M., & Blancafort, P. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7774-1_2 · Cited by 114 · see citing works

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma

Beane, J. D., Lee, G., Zheng, Z., Mendel, M. C., Abate‐Daga, D., Bharathan, M., Black, M. A., Gandhi, N. H., Yu, Z., Chandran, S. S., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.71 · Cited by 111 · see citing works

Genome Editing Technologies: Defining a Path to Clinic

Corrigan‐Curay, J., O’Reilly, M., Kohn, D. B., Cannon, P. M., Bao, G., Bushman, F. D., Carroll, D., Cathomen, T., Joung, J. K., Roth, D. B., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.54 · Cited by 101 · see citing works

CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication

Tebas, P., Jadlowsky, J. K., Shaw, P. A., Tian, L., Esparza, E., Brennan, A. L., Kim, S. K., Naing, S. Y., Richardson, M. W., Vogel, A. N., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144486 · Cited by 100 · see citing works

Engineering nucleases for gene targeting: safety and regulatory considerations

Pauwels, K., Podevin, N., Breyer, D., Carroll, D., & Herman, P. (2013) · New Biotechnology · doi:10.1016/j.nbt.2013.07.001 · Cited by 93 · see citing works

RNA interference approaches for treatment of HIV-1 infection

Bobbin, M. L., Burnett, J., & Rossi, J. J. (2015) · Genome Medicine · doi:10.1186/s13073-015-0174-y · Cited by 93 · see citing works

Engineering Gene Therapy: Advances and Barriers

Shahryari, A., Burtscher, I., Nazari, Z., & Lickert, H. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100040 · Cited by 84 · see citing works

Newer Gene Editing Technologies toward HIV Gene Therapy

Manjunath, N., Yi, G., Dang, Y., & Shankar, P. (2013) · Viruses · doi:10.3390/v5112748 · Cited by 77 · see citing works

The clinical applications of genome editing in HIV

Wang, C. X., & Cannon, P. M. (2016) · Blood · doi:10.1182/blood-2016-01-678144 · Cited by 72 · see citing works

Synthetic epigenetics—towards intelligent control of epigenetic states and cell identity

Jurkowski, T. P., Ravichandran, M., & Stepper, P. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0044-x · Cited by 71 · see citing works

One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors

Schiwon, M., Ehrke‐Schulz, E., Oswald, A., Bergmann, T., Michler, T., Protzer, U., & Ehrhardt, A. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.05.006 · Cited by 70 · see citing works

Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection

Allen, A. G., Chung, C.-H., Atkins, A., Dampier, W., Khalili, K., Nonnemacher, M. R., & Wigdahl, B. L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02940 · Cited by 70 · see citing works

Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group

Cavazza, A., Molina-Estévez, F. J., Reyes, Á. P., Ronco-Díaz, V., Naseem, A., Malenšek, Š., Pečan, P., Santini, A., Heredia, P., Aguilar-González, A., et al. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102457 · Cited by 70 · see citing works

Genome Editing B.C. (Before CRISPR): Lasting Lessons from the “Old Testament”

Urnov, F. D. (2018) · The CRISPR Journal · doi:10.1089/crispr.2018.29007.fyu · Cited by 68 · see citing works

Transcription activator like effector (TALE)-directed piggyBac transposition in human cells

Owens, J. B., Mauro, D., Stoytchev, I., Bhakta, M. S., Kim, M., Segal, D. J., & Moisyadi, S. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt677 · Cited by 67 · see citing works

Improved Cell-Penetrating Zinc-Finger Nuclease Proteins for Precision Genome Engineering

Liu, J., Gaj, T., Wallen, M. C., & Barbas, C. F. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.6 · Cited by 61 · see citing works

A history of genome editing in mammals

Fernández, A., Josa, S., & Montoliu, L. (2017) · Mammalian Genome · doi:10.1007/s00335-017-9699-2 · Cited by 68 · see citing works

Precision genome editing: A small revolution for glycobiology

Steentoft, C., Bennett, E., Schjoldager, K. T.-B. G., Vakhrushev, S. Y., Wandall, H. H., & Clausen, H. (2014) · Glycobiology · doi:10.1093/glycob/cwu046 · Cited by 59 · see citing works

Genome Therapy of Myotonic Dystrophy Type 1 iPS Cells for Development of Autologous Stem Cell Therapy

Gao, Y., Guo, X., Santostefano, K. E., Wang, Y., Reid, T. S., Zeng, D., Terada, N., Ashizawa, T., & Xia, G. (2016) · Molecular Therapy · doi:10.1038/mt.2016.97 · Cited by 58 · see citing works

Engineering T Cells to Functionally Cure HIV-1 Infection

Leibman, R. S., & Riley, J. L. (2015) · Molecular Therapy · doi:10.1038/mt.2015.70 · Cited by 55 · see citing works

RNA-Guided Genome Editing of Mammalian Cells

Pyzocha, N., Ran, F. A., Hsu, P. D., & Zhang, F. (2014) · Methods in molecular biology · doi:10.1007/978-1-62703-761-7_17 · Cited by 53 · see citing works

Targeted Integration of a Super-Exon into the CFTR Locus Leads to Functional Correction of a Cystic Fibrosis Cell Line Model

Bednarski, C., Tomczak, K., Hövel, B. V., Weber, W.-M., & Cathomen, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161072 · Cited by 53 · see citing works

CCR5 Gene Editing of Resting CD4+ T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized Mice

Yi, G., Choi, J. G., Bharaj, P., Abraham, S., Dang, Y., Kafri, T., Alozie, O. K., Manjunath, M. N., & Shankar, P. (2014) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2014.52 · Cited by 52 · see citing works

Clinical Development of Gene Therapies: The First Three Decades and Counting

Lapteva, L., Purohit-Sheth, T., Serabian, M., & Puri, R. (2020) · Molecular Therapy: Methods & Clinical Development · doi:10.1016/j.omtm.2020.10.004 · Cited by 46 · see citing works

Genetic correction using engineered nucleases for gene therapy applications

Li, H. L., Nakano, T., & Hotta, A. (2013) · Development Growth & Differentiation · doi:10.1111/dgd.12107 · Cited by 48 · see citing works

The Future of Gene Therapy: A Review of In Vivo and Ex Vivo Delivery Methods for Genome Editing-Based Therapies

Volodina, O., & Smirnikhina, S. (2024) · Molecular Biotechnology · doi:10.1007/s12033-024-01070-4 · Cited by 46 · see citing works

Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression

Kabadi, A. M., & Gersbach, C. A. (2014) · Methods · doi:10.1016/j.ymeth.2014.06.014 · Cited by 45 · see citing works

Genome editing strategies: potential tools for eradicating HIV-1/AIDS

Khalili, K., Kaminski, R., Gordon, J., Cosentino, L., & Hu, W. (2015) · Journal of NeuroVirology · doi:10.1007/s13365-014-0308-9 · Cited by 48 · see citing works

Integrating HDAd5/35++ Vectors as a New Platform for HSC Gene Therapy of Hemoglobinopathies

Li, C., Psatha, N., Wang, H., Singh, M., Samal, H. B., Zhang, W., Ehrhardt, A., Izsvák, Z., Papayannopoulou, T., & Lieber, A. (2018) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.02.004 · Cited by 42 · see citing works

Current application of CRISPR/Cas9 gene-editing technique to eradication of HIV/AIDS

Huang, Z., Tomitaka, A., Raymond, A., & Nair, M. (2017) · Gene Therapy · doi:10.1038/gt.2017.35 · Cited by 42 · see citing works

High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k “Helper” Proteins

Gwiazda, K., Grier, A. E., Sahni, J., Burleigh, S. M., Martin, U., Yang, J., Popp, N. A., Krutein, M. C., Khan, I., Jacoby, K., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.105 · Cited by 34 · see citing works

Adenoviral Vectors Meet Gene Editing: A Rising Partnership for the Genomic Engineering of Human Stem Cells and Their Progeny

Tasca, F., Wang, Q., & Gonçalves, M. A. F. V. (2020) · Cells · doi:10.3390/cells9040953 · Cited by 34 · see citing works

Recent developments and clinical studies utilizing engineered zinc finger nuclease technology

Jo, Y.-I., Kim, S., & Ramakrishna, S. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1956-5 · Cited by 36 · see citing works

Advancing gene editing therapeutics: Clinical trials and innovative delivery systems across diverse diseases

Raigani, M., Eftekhari, Z., Adeli, A., & Kazemi‐Lomedasht, F. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102666 · Cited by 35 · see citing works

Gene Therapy Strategies to Exploit TRIM Derived Restriction Factors against HIV-1

Chan, E., Towers, G. J., & Qasim, W. (2014) · Viruses · doi:10.3390/v6010243 · Cited by 33 · see citing works

CAR Talk: How Cancer-Specific CAR T Cells Can Instruct How to Build CAR T Cells to Cure HIV

Kim, G. B., Hege, K. M., & Riley, J. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02310 · Cited by 30 · see citing works

DNA cleavage enzymes for treatment of persistent viral infections: Recent advances and the pathway forward

Weber, N. D., Aubert, M., Dang, C. H., Stone, D., & Jerome, K. R. (2014) · Virology · doi:10.1016/j.virol.2013.12.037 · Cited by 28 · see citing works

The evolution and history of gene editing technologies

Randhawa, S., & Sengar, S. (2021) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2021.01.002 · Cited by 30 · see citing works

Novel Humanized Peripheral Blood Mononuclear Cell Mouse Model with Delayed Onset of Graft-versus-Host Disease for Preclinical HIV Research

Holguin, L., Echavarria, L., & Burnett, J. C. (2021) · Journal of Virology · doi:10.1128/jvi.01394-21 · Cited by 27 · see citing works

Lessons to be Learned from Natural Control of HIV – Future Directions, Therapeutic, and Preventive Implications

Shasha, D., & Walker, B. D. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00162 · Cited by 25 · see citing works

Rh D blood group conversion using transcription activator-like effector nucleases

Kim, Y., Kim, H. O., Baek, E. J., Kurita, R., Cha, H., Nakamura, Y., & Kim, S. (2015) · Nature Communications · doi:10.1038/ncomms8451 · Cited by 24 · see citing works

Therapeutic application of the CRISPR system: current issues and new prospects

Lee, M., & Kim, S. (2019) · Human Genetics · doi:10.1007/s00439-019-02028-2 · Cited by 23 · see citing works

Novel AIDS therapies based on gene editing

Khalili, K., White, M. K., & Jacobson, J. M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2479-z · Cited by 23 · see citing works

The Emerging Role of the Serine Incorporator Protein Family in Regulating Viral Infection

Xu, S., Zheng, Z., Pathak, J. L., Cheng, H., Zhou, Z., Chen, Y., Wu, Q., Wang, L., Zeng, M., & Wu, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.856468 · Cited by 22 · see citing works

Glycosylphosphatidylinositol-Anchored Anti-HIV scFv Efficiently Protects CD4 T Cells from HIV-1 Infection and Deletion in hu-PBL Mice

Ye, C., Wang, W., Cheng, L., Li, G., Wen, M., Wang, Q., Zhang, Q., Li, D., Zhou, P., & Su, L. (2016) · Journal of Virology · doi:10.1128/jvi.01389-16 · Cited by 22 · see citing works

Current State of Therapeutics for HTLV-1

Wang, T. T., Hirons, A., Doerflinger, M., Morris, K. V., Ledger, S., Purcell, D. F. J., Kelleher, A. D., & Ahlenstiel, C. L. (2024) · Viruses · doi:10.3390/v16101616 · Cited by 22 · see citing works

“Therapeutic applications of the ‘NPGP’ family of viral 2As”

Luke, G. A., & Ryan, M. D. (2018) · Reviews in Medical Virology · doi:10.1002/rmv.2001 · Cited by 20 · see citing works

Could gene therapy cure HIV?

Sheykhhasan, M., Foroutan, A., Manoochehri, H., Khoei, S. G., Poondla, N., & Saidijam, M. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119451 · Cited by 20 · see citing works

Development of Lentiviral Vectors Simultaneously Expressing Multiple siRNAs Against CCR5, vif and tat/rev Genes for an HIV-1 Gene Therapy Approach

Spanevello, F., Calistri, A., Vecchio, C. D., Mantelli, B., Frasson, C., Basso, G., Palù, G., Cavazzana, M., & Parolin, C. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.24 · Cited by 19 · see citing works

An Efficient Large-Scale Retroviral Transduction Method Involving Preloading the Vector into a RetroNectin-Coated Bag with Low-Temperature Shaking

Dodo, K., Chono, H., Saito, N., Tanaka, Y., Tahara, K., Nukaya, I., & Mineno, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086275 · Cited by 19 · see citing works

Gene therapy of hematological disorders: current challenges

Al-Saif, A. M. (2019) · Gene Therapy · doi:10.1038/s41434-019-0093-4 · Cited by 18 · see citing works

Genetic rearrangements of variable di-residue (RVD)-containing repeat arrays in a baculoviral TALEN system

Lau, C., Zhu, H., Tay, J. C.-K., Li, Z., Tay, F. C., Chen, C., Tan, W.-K., Du, S., Sia, V.-K., Phang, R.-Z., et al. (2014) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2014.50 · Cited by 18 · see citing works

Generation of CCR5-defective CD34 cells from ZFN-driven stop codon-integrated mesenchymal stem cell clones

Manotham, K., Chattong, S., & Setpakdee, A. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0130-6 · Cited by 18 · see citing works

Genome editing technologies to fight infectious diseases

Trevisan, M., Palù, G., & Barzon, L. (2017) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2017.1400379 · Cited by 18 · see citing works

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance

Ibarra, G. S. R., Paul, B., Sather, B. D., Younan, P. M., Sommer, K., Kowalski, J. P., Hale, M. R., Stoddard, B. L., Jarjour, J., Astrakhan, A., et al. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.56 · Cited by 17 · see citing works

Gene‐based therapies of neuromuscular disorders: an update and the pivotal role of patient organizations in their discovery and implementation

Braun, S. (2013) · The Journal of Gene Medicine · doi:10.1002/jgm.2747 · Cited by 17 · see citing works

Genome Engineering in Human Cells

Song, M., Kim, Y., Kim, J., & Kim, S. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801185-0.00005-2 · Cited by 18 · see citing works

Correcting inborn errors of immunity: From viral mediated gene addition to gene editing

Castiello, M. C., Ferrari, S., & VILLA, A. M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101731 · Cited by 16 · see citing works

TALENs-mediated homozygous CCR5Δ32 mutations endow CD4+ U87 cells with resistance against HIV‑1 infection

Yu, A. Q., Ding, Y., Lu, Z. Y., Yan, H., Teng, Z., Yan, S., Li, D., & Zeng, Y. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7889 · Cited by 16 · see citing works

Zebrafish as a Versatile Model for Cardiovascular Research: Peering into the Heart of the Matter

Angom, R. S., Singh, M., Muhammad, H., Varanasi, S. M., & Mukhopadhyay, D. (2025) · Cells · doi:10.3390/cells14070531 · Cited by 15 · see citing works

Progress toward curing HIV infection with hematopoietic cell transplantation

Petz, L. D., Burnett, J., Li, H., Li, S., Tonai, R., Bakalinskaya, M., Shpall, E. J., Armitage, S. K., Kurtzberg, J., Regan, D. M., et al. (2015) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s56050 · Cited by 15 · see citing works

Gene Therapy Strategies for HIV/AIDS: Preclinical Modeling in Humanized Mice

Bennett, M. S., & Akkina, R. (2013) · Viruses · doi:10.3390/v5123119 · Cited by 15 · see citing works

Potential mechanisms for cell-based gene therapy to treat HIV/AIDS

Herrera-Carrillo, E., & Berkhout, B. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.980236 · Cited by 15 · see citing works

Lentiviral protein delivery of meganucleases in human cells mediates gene targeting and alleviates toxicity

He, C., Gouble, A., Bourdel, A., Manchev, V. T., Poirot, L., Pâques, F., Duchateau, P. N., Edelman, A., & Danos, O. (2014) · Gene Therapy · doi:10.1038/gt.2014.51 · Cited by 11 · see citing works

Gene Editing

Ando, D. G., & Meyer, K. E. (2017) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2017.06.002 · Cited by 12 · see citing works

The Cas9 Hammer—and Sickle: A Challenge for Genome Editors

Urnov, F. D. (2021) · The CRISPR Journal · doi:10.1089/crispr.2021.29120.fur · Cited by 11 · see citing works

CAR-T cells leave the comfort zone: current and future applications beyond cancer

Mazzi, M. T., Hajdu, K. L., Ribeiro, P. R., & Bonamino, M. (2020) · Immunotherapy Advances · doi:10.1093/immadv/ltaa006 · Cited by 12 · see citing works

Interventions during Early Infection: Opening a Window for an HIV Cure?

Hiner, C. R., Mueller, A. L., Su, H., & Goldstein, H. (2024) · Viruses · doi:10.3390/v16101588 · Cited by 8 · see citing works

Infusion of CCR5 Gene-Edited T Cells Allows Immune Reconstitution, HIV Reservoir Decay, and Long-Term Virological ControlPreprint

Zeidan, J., Sharma, A., Lee, G., Raad, A., Fromentin, R., Fourati, S., Ghneim, K., Sánchez, G. P., Benne, C., Canderan, G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.28.433290 · Cited by 8 · see citing works

Stem cell reprogramming: Basic implications and future perspective for movement disorders

Brändl, B., Schneider, S. A., Loring, J. F., Hardy, J., Gribbon, P. M., & Müller, F. (2014) · Movement Disorders · doi:10.1002/mds.26113 · Cited by 7 · see citing works

Engineered T cell therapies

Field, A.-C., & Qasim, W. (2015) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2015.14 · Cited by 7 · see citing works

Identifying Opinion Leaders in Virtual Travel Community Based on Social Network Analysis

Yang, J., Zhang, Y., & Liu, L. (2019) · Lecture notes in computer science · doi:10.1007/978-3-030-22338-0_23 · Cited by 7 · see citing works

Efficient ZFN-Mediated Stop Codon Integration into the CCR5 Locus in Hematopoietic Stem Cells: A Possible Source for Intrabone Marrow Cell Transplantation

Chattong, S., Chaikomon, K., Chaiya, T., Tangkosakul, T., Palavutitotai, N., Anusornvongchai, T., & Manotham, K. (2018) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2018.0007 · Cited by 6 · see citing works

Progress and prospects of engineered sequence-specific DNA modulating technologies for the management of liver diseases

Nicholson, S. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i6.859 · Cited by 5 · see citing works

PlmCas12e (CasX2) cleavage of CCR5: impact of guide RNA spacer length and PAM sequence on cleavage activity

Armstrong, D. A., Hudson, T. R., Hodge, C. A., Hampton, T. H., Howell, A. L., & Hayden, M. S. (2023) · RNA Biology · doi:10.1080/15476286.2023.2221510 · Cited by 5 · see citing works

Personalized gene therapy locks out HIV, paving the way to control virus without antiretroviral drugs

Levine, B. L., Leskowitz, R. M., & Suhoski, M. M. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1035644 · Cited by 5 · see citing works

Genomic Engineering

Walker‐Daniels, J. (2013) · Materials and Methods · doi:10.13070/mm.en.3.164 · Cited by 5 · see citing works

The Development and Use of Zinc-Finger Nucleases

Carroll, D. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-3509-3_2 · Cited by 5 · see citing works

Optimizing Delivery and Expression of Designer Nucleases for Genome Engineering

Chuah, M., & VandenDriessche, T. (2013) · Human Gene Therapy Methods · doi:10.1089/hgtb.2013.166 · Cited by 5 · see citing works

Proximate Analysis, Vitamins, and Mineral Compositions of Zingiber officinale, Ocimum gratissimum and their Herbal Blend

Ibeabuchi, C. G., Patrick-Iwuanyanwu, K. C., Oyeike, E. N., & Akaninwor, J. O. (2023) · IPS Journal of Nutrition and Food Science · doi:10.54117/ijnfs.v2i2.27 · Cited by 4 · see citing works

Cell therapies for treatment of human immunodeficiency virus infection

Focosi, D., Maggi, F., Ceccherini‐Nelli, L., & Pistello, M. (2015) · Reviews in Medical Virology · doi:10.1002/rmv.1831 · Cited by 4 · see citing works

Novel Approaches Based on Autologous Stem Cell Engineering and Gene- Modification; Evidence for the Cure of HIV/AIDS

Esmaeilzadeh, A., & Farshbaf, A. (2015) · Journal of Genetic Syndromes & Gene Therapy · doi:10.4172/2157-7412.1000e130 · Cited by 4 · see citing works

Generation of Stable Knockout Mammalian Cells by TALEN-Mediated Locus-Specific Gene Editing

Mahata, B., & Biswas, K. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6472-7_7 · Cited by 3 · see citing works

Genomic Editing—From Human Health to the “Perfect Child”

Iancu, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813764-2.00001-5 · Cited by 3 · see citing works

Zinc Finger Nuclease Editing of Hematopoietic Stem Cells as an Anti-HIV Therapy

Holt, N. G., Exline, C. M., Mulhern, O., Hofer, U., Burke, K. A., Oldenburg, J. E., & Cannon, P. M. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1655-9_32 · Cited by 2 · see citing works

CAS12e (CASX2) CLEAVAGE OF CCR5: IMPACT OF GUIDE RNA LENGTH AND PAM SEQUENCE ON CLEAVAGE ACTIVITYPreprint

Armstrong, D. A., Hudson, T. R., Hodge, C. A., Hampton, T. H., Howell, A. L., & Hayden, M. S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.02.522476 · Cited by 2 · see citing works

Genomic editing: From human health to the “perfect child”

Iancu, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19045-2.00003-9 · Cited by 1 · see citing works

Gene Editing of <i>CCR5</i> in Autologous CD4 T Cells of Persons Infected with HIV

Tebas, P., Stein, D., Tang, W. W., Frank, I., Wang, S. Q., Lee, G., Spratt, S. K., Surosky, R. T., Giedlin, M. A., Nichol, G., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1300662 · Cited by 1,357 · see citing works

Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells

DiGiusto, D. L., Cannon, P. M., Holmes, M. C., Li, L., Rao, A., Wang, J., Lee, G., Gregory, P. D., Kim, K. A., Hayward, S. B., et al. (2016) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2016.67 · Cited by 114 · see citing works

541. Gene Modification at Clinical Scale: Engineering Resistance to HIV Infection Via Targeted Disruption of the HIV Co-Receptor CCR5 Gene in CD4+ T Cells Using Modified Zinc Finger Protein Nucleases

(2008) · Molecular Therapy · doi:10.1016/s1525-0016(16)39944-0

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

Holt, N., Wang, J., Kim, K., Friedman, G., Wang, X., Taupin, V., Crooks, G. M., Kohn, D. B., Gregory, P. D., Holmes, M. C., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1663 · Cited by 677 · see citing works

Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases

Li, L., Krymskaya, L., Wang, J., Henley, J., Rao, A., Cao, L.-F., Tran, C.-A., Torres-Coronado, M., Gardner, A., Gonzalez, N., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.65 · Cited by 181 · see citing works