The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Oligonucleotide Therapies: The Past and the Present
Open accessAbstract
In this review we address the development of oligonucleotide (ON) medicines from a historical perspective by listing the landmark discoveries in this field. The various biological processes that have been targeted and the corresponding ON interventions found in the literature are discussed together with brief updates on some of the more recent developments. Most ON therapies act through antisense mechanisms and are directed against various RNA species, as exemplified by gapmers, steric block ONs, antagomirs, small interfering RNAs (siRNAs), micro-RNA mimics, and splice switching ONs. However, ONs binding to Toll-like receptors and those forming aptamers have completely different modes of action. Similar to other novel medicines, the path to success has been lined with numerous failures, where different therapeutic ONs did not stand the test of time. Since the first ON drug was approved for clinical use in 1998, the therapeutic landscape has changed considerably, but many challenges remain until the expectations for this new form of medicine are met. However, there is room for cautious optimism.
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1 retracted
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“that bacterial CpG triggers the activation of Blymphocytes,(12) and this was followed by the cloning of the corresponding receptor, named TLR9, in the year 2000.(13) While the TLR intracellular signaling pathways have been delineated,(14) it is interesting to note that short DNA ONs impair TLR3 signaling in both prima…”
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Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts
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Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development
Schulz, S., Becker, M., Groseclose, M. R., Schadt, S., & Hopf, C. (2019) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2018.08.003 · Cited by 325
Therapeutic Oligonucleotides: State of the Art
Smith, C. I. E., & Zain, R. (2019) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021050 · Cited by 323
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Metadata
- Authors
- Lundin, K. E., Gissberg, O., & Smith, C. I. E.
- Venue
- Human Gene Therapy
- Publisher
- SAGE Publications
- Published
- 2015-08
- Volume
- 26
- Issue
- 8
- Pages
- 475-485
- ISSN
- 1043-0342 (ISSN-L)
- 1557-7422
- OpenAlex
- W1952915322
- Cited by
- 267
- References
- 127
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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