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Cited by 46Coconut Research and ApplicationsNatural Products and Biological ResearchCholesterol and Lipid Metabolism

Beneficial effects of coconut water feeding on lipid metabolism in cholesterol-fed rats

Sandhya, V.G., Rajamohan, T.·2006·Journal of Medicinal Food
DOI 10.1089/jmf.2006.9.400
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Abstract

The purpose of this study was to determine the effect of coconut water feeding in cholesterol-fed rats. Male albino rats were fed tender coconut water and mature coconut water at a dose level of 4 mL/100 g of body weight. Cholesterol feeding caused a marked increase in total cholesterol, very low-density lipoprotein (VLDL) + low-density lipoprotein (LDL) cholesterol, and triglycerides in serum. Administration of coconut water counteracts the increase in total cholesterol, VLDL + LDL cholesterol, and triglycerides, while high-density lipoprotein cholesterol was higher. Lipid levels in the tissues viz. liver, heart, kidney, and aorta were markedly decreased in cholesterol-fed rats supplemented with coconut water. Feeding coconut water resulted in increased activities of 3-hydroxy-3-methylglutaryl-CoA reductase in liver, lipoprotein lipase in heart and adipose tissue, and plasma lecithin:cholesterol acyl transferase, while lipogenic enzymes showed decreased activities. An increased rate of cholesterol conversion to bile acid and an increased excretion of bile acids and neutral sterols were observed in rats fed coconut water. Histopathological studies of liver and aorta revealed much less fatty accumulation in these tissues in cholesterol-fed rats supplemented with coconut water. Feeding coconut water resulted in increased plasma L-arginine content, urinary nitrite level, and nitric oxide synthase activity. These results indicate that both tender and mature coconut water has beneficial effects on serum and tissue lipid parameters in rats fed cholesterol-containing diet.

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Crossref · 10.1089/jmf.2006.9.400

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  • Administering coconut water (4 mL/100 g body weight) in male rats counteracted the increases in these substances promoted by cholesterol feeding.

    “Administering coconut water (4 mL/100 g body weight) in male rats counteracted the increases in these substances promoted by cholesterol feeding.”

    From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [69]

  • Tender coconut water could reduce total cholesterol, very-low density lipoprotein, low density lipoprotein, and triglyceride levels in serum.

    “Tender coconut water could also reduce total cholesterol, very-low density lipoprotein, low density lipoprotein, and triglyceride levels in serum (69).”

    From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [69]

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Authors
Sandhya, V. G., & Rajamohan, T.
Affiliations
University of Kerala (IN)
Venue
Journal of Medicinal Food
Publisher
SAGE Publications
Published
2006-09
Volume
9
Issue
3
Pages
400-407
ISSN
  • 1096-620X (ISSN-L)
  • 1557-7600
DOI
10.1089/jmf.2006.9.400
OpenAlex
W2055038747
Cited by
46
References
35
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 2
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Journal of Medicinal Food (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
coconut water, dietary cholesterol, lipid metabolism, hypercholesterolemia, serum cholesterol, triglycerides, HDL cholesterol, HMG-CoA reductase, lipoprotein lipase, lecithin:cholesterol acyltransferase, bile acid synthesis, cholesterol excretion, hepatic steatosis, L-arginine, nitric oxide synthase, nitrite
MeSH terms
Animals, Aorta, Bile Acids and Salts, Cholesterol, Cholesterol, Dietary, Cocos, Diet, Feces, Fruit, Hydroxymethylglutaryl CoA Reductases, Kidney, Lipids, Cholesterol, HDL, Cholesterol, LDL, Liver, Male, Myocardium, Triglycerides, Cholesterol, VLDL, Weight Gain, Rats, Sprague-Dawley, Lipid Metabolism, Rats

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