Zeatin Prevents Amyloid β -Induced Neurotoxicity and Scopolamine-Induced Cognitive Deficits
Abstract
The antioxidative and protective effects of zeatin against amyloid beta-protein (Abeta)-induced neurotoxicity were investigated using PC12 cells. Zeatin showed antioxidative and cell protective effects against Abeta-induced neurotoxicity. In this study, we also evaluated the effect of zeatin on learning and memory capacity in vivo using ICR mice with amnesia induced by scopolamine (1 mg/kg of body weight). Zeatin, when administered to mice at 4.5 mg/kg of body weight, significantly ameliorated scopolamine-induced amnesia as measured in both the passive avoidance test and Y-maze test. Injecting mice with scopolamine impaired performance on the passive avoidance test (48 +/- 4.5% decrease) and on the Y-maze test (12 +/- 1.3% decrease). In contrast, mice treated with zeatin before scopolamine injections were protected from these changes (5-34% decrease in step-through latency; 1-4% decrease in alternation behavior). The present results suggest a possible chemopreventive role of zeatin in Alzheimer's disease.
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trans-zeatin can prevent amyloid β-protein formation.
“Another recent study also found that trans-zeatin can prevent amyloid β-protein formation, which has a causal role in the development and progress of Alzheimer’s disease [83].”
From The Chemical Composition and Biological Properties of Coconut (Cocos nucifera L.) Water (2009) · cites this paper as [83]
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The Chemical Composition and Biological Properties of Coconut (Cocos nucifera L.) Water
Yong, J. W. H., Ge, L., Ng, Y. F., & Tan, S. N. (2009) · Molecules · doi:10.3390/molecules14125144 · Cited by 753 · see citing works
“Another recent study also found that transzeatin can prevent amyloid β-protein formation, which has a causal role in the development and progress of Alzheimer’s disease [83].”
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Williams, P., Sorribas, A., & Howes, M.-J. R. (2011) · Nat. Prod. Rep. · doi:10.1039/c0np00027b · Cited by 404 · see citing works
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Rethinam, P., & Krishnakumar, V. (2022) · Coconut Water · doi:10.1007/978-3-031-10713-9_4 · Cited by 9 · see citing works
Go, M. J., Kim, J. M., Kang, J. Y., Park, S. K., Lee, C. J., Kim, M. J., Lee, H. R., Kim, T. Y., Joo, S. G., Kim, D.-O., et al. (2022) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2207.07015 · Cited by 9 · see citing works
- Authors
- Choi, S. J., Jeong, C.-H., Choi, S.-G., Chun, J.-Y., Kim, Y. J., Lee, J., Shin, D.-H., & Heo, H. J.
- Affiliations
- Gyeongsang National University (KR)
- Division of Food Science, Sunchon National University, Suncheon, Jeonam, Republic of Korea
- Korea University (KR)
- Kyung Hee University (KR)
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2009-04
- Volume
- 12
- Issue
- 2
- Pages
- 271-277
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W2053480988
- Cited by
- 39
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- zeatin, amyloid-beta, neurotoxicity, scopolamine-induced amnesia, cognitive impairment, antioxidant activity, neuroprotection, PC12 cells, Alzheimer's disease, chemoprevention, learning and memory, passive avoidance
- MeSH terms
- Alzheimer Disease, Amnesia, Animals, Antioxidants, Behavior, Animal, Brain, Cognition Disorders, Learning, Phytotherapy, Memory, Mice, Inbred ICR, Plant Extracts, Scopolamine, Zeatin, Lipid Peroxidation, Amyloid beta-Peptides, PC12 Cells, Reactive Oxygen Species, Plant Leaves, Cholinergic Antagonists, Protective Agents, Neurotoxicity Syndromes, Morus, Mice, Rats
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