Korean Red Pine (Pinus densiflora) Bark Extract Attenuates Aβ-Induced Cognitive Impairment by Regulating Cholinergic Dysfunction and Neuroinflammation
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Min Ji Go, Jong Min Kim, Jin Yong Kang, Seon Kyeong Park, Chang Jun Lee, Min Ji Kim, Hyo Rim Lee, Tae Yoon Kim, Seung Gyum Joo, Dae-Ok Kim, and Ho Jin Heo. J. Microbiol. Biotechnol. 2022;32:1154-67. https://doi.org/10.4014/jmb.2207.07015
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Pinus densiflora extract (15-30 mg/kg) improved cognitive function and reduced AChE activity, while increasing antioxidant levels, reducing neuroinflammation, and enhancing mitochondrial activity in amyloid beta-treated ICR mice.
“Pinus densiflora extract (15–30 mg/kg) improved cognitive function and reduced AChE activity, while increasing antioxidant levels, reducing neuroinflammation, and enhancing mitochondrial activity in Aβ-treated ICR mice [79].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [79]
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- Authors
- Go, M. J., Kim, J. M., Kang, J. Y., Park, S. K., Lee, C. J., Kim, M. J., Lee, H. R., Kim, T. Y., Joo, S. G., Kim, D.-O., & Heo, H. J.
- Affiliations
- Gyeongsang National University (KR)
- Kyung Hee University (KR)
- ORCID
- Venue
- Journal of Microbiology and Biotechnology
- Published
- 2022-08-02
- Volume
- 32
- Issue
- 9
- Pages
- 1154-1167
- ISSN
- 1017-7825 (ISSN-L)
- 1738-8872
- PMC
- PMC9628973
- OpenAlex
- W4293535893
- Cited by
- 9
- References
- 81
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 6
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Journal of Microbiology and Biotechnology (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Agriculture, Food and Rural Affairs of Korea (202103560001)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Keywords
- Korean red pine, Pinus densiflora, bark extract, amyloid-beta, cognitive impairment, cholinergic dysfunction, neuroinflammation, Alzheimer's disease
- MeSH terms
- NF-KappaB Inhibitor alpha, Neuroinflammatory Diseases, Acetylcholine, Acetylcholinesterase, Adenosine Triphosphate, Animals, Antioxidants, Choline O-Acetyltransferase, Glutathione, Malondialdehyde, Plant Extracts, Superoxide Dismutase, Tumor Necrosis Factor-alpha, Amyloid beta-Peptides, Synaptophysin, Reactive Oxygen Species, Oxidative Stress, Cholinergic Agents, Neuroprotective Agents, Brain-Derived Neurotrophic Factor, Plant Bark, Pinus, bcl-2-Associated X Protein, Mice, Republic of Korea, Cognitive Dysfunction
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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